CD99L2 gene and related diseases / 国际儿科学杂志

CD99L2(CD99 antigen-like 2)gene is located at Xq28, which encodes a highly conserved and widely expressed glycosylated transmembrane protein.Since it was first reported in 2003, CD99L2 protein has been regarded as an important adhesion molecule, which plays an important role in inflammation, leukocyte exudation, and lymphoma.However, in recent years, more and more studies have found that this gene is closely related to neurological diseases such as autism spectrum disorder, cerebral palsy, and epilepsy, but the specific mechanism is still unclear, and the function of this gene is still unclear.This article reviews the research progress of CD99L2 gene.