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Objective To observe the effects of Buyang Huanwu Decoction(BHD)on collateral circulation of patients with acute cerebral infarction(ACI)through transcranial Doppler sonography(TCD). Methods The randomized controlled trial methods were applied, and 80 ACI patients were randomly divided into treatment group and control group, 40 cases in each group. Two cases from each group were dropped out, and the left 38 cases of each group were included into the analysis. The control group was treated with the standardized western medicine regimen, and the treatment group was given BHD orally on the basis of treatment for the control group. The treatment for the two groups covered 7 days. On treatment day 3 and 7, TCD was adopted to investigate the blood flow velocity of the responsible vessels and the improvement of collateral circulation compensation. On treatment day 7, the scores of National Institute of Health Stroke Scale(NIHSS) in the two groups were compared. Results (1) On treatment day 3, collateral circulation improvement occurred in 12 patients(accounting for 31.58%)from the treatment group , and on treatment day 7 , the improved cases increased to 16(accounting for 42.11%). In the control group , 3 cases(7 . 89%) were improved on treatment day 3 , and 4(10 . 53%) improved on treatment day 7. The treatment group had better effect on improving collateral circulation than the control group, the difference being significant(P<0.01). (2) In the treatment group, 9 cases had increased blood flow velocity(Vm) of the responsible vessels on treatment day 3, and 11 cases had the increase on treatment day 7. In the control group, Vm increase occurred in one case both on treatment day 3 and 7. The treatment group had better effect on increasing Vm than the control group, the difference being significant(P<0.05). (3) On treatment day 7, NIHSS scores were decreased in both groups(P<0.05 or P<0.01), and the decrease of the treatment group was superior to that of the control group(P<0.01).(4) No adverse event was shown in the two g roups during the treatment. Conclusion BHD can constantly improve the blood flow velocity of the responsible vessel and promote collateral vessel building , which results into the recovery of the impaired neural function.
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[Objective] To investigate the effects of Yiqi Huoxue Tablet (YHT, mainly composed of Radix Angelicae Sinensis, Herba Leonuri, Rhizoma Chuanxiong , Radix Astragali ) on expression of platelet membrane adhesion molecules (PMAM) in whole blood of rats with cerebral infarction. [Methods] Flow cytometry was used to detect the expression of PMAM (CD
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ive] To observe the therapeutic effect of Naoxing Granule (NG) for acute ischemic stroke (AIS) and to explore its mechanism. [Methods] Single-blind controlled trial was applied. Two hundred cases of AIS were randomly allocated to Group A (n = 150, treated with NG) and Group B (n = 50, treated with nimodipine). Therapeutic effect of NG was observed and plasma free radical levels and the ratio of thromboxane A2 (TXA2) and prostaglandin 2 (PGI2) were detected. [Results] The total effective rate was 91.3%and 76.0% , and the remarkably effective rate was 62.0% and 46.0% in Group A and Group B respectively ( P
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Objective To observe the effect of Fujian Tablets(FT),a prescription with the actions of nourishing liver and kidney,on the expression of microtubule-associated protein 2(MAP-2) in cerebral infarction rats at different time points,and to explore its mechanism on promoting nerve cell differentiation.Methods A total of 240 male Sprague Dawley rats were divided into normal control group,sham-operation group,model group and FT group.Focal cerebral ischemia models were established by occlusion of the middle cerebral artery according to the reformed Longa method in rats,and were subdivided into 3-,7-,14-,28-,and 42-day cerebral infarction subgroups.FT group was given FT in the dose of 9 g?kg-1?d-1,and the other groups were given the same dose of distilled water.Results In the model group,MAP-2 expression in the hippocampus increased and reached a peak on day 3,which were notably different from that in the normal control group(P0.05).In FT group,MAP-2 expression increased on day 3,reached a peak on day 7,remained high level till day 14,and then decreased,the difference being significant compared with the model group(P
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【Objective】To assess the efficacy and safety of Tongxinluo Capsules for cerebrovascular disorders by meta analysis.【Methods】Randomized controlled trials(RCT) of Tongxinluo Capsules for cerebrovascular disorders were got by searching China Journal Full-text Database(from 1996 to May,2006),China Best Doctoral and Master's Dissertations(from 1996 to May,2006),MEDLINE(from 1996 to May,2006),and Cochrane Library with computer,and were screened by manual search.RevMan 4.2 software and SAS were used in Meta-analysis.【Results】Thirty seven RCT were included,in which involved 2791 patients.Among them,1764 patients were treated with Tongxinluo Capsules,and other 1572 served as the controls. Meta-analysis results showed that the difference of the total efficacy in 31 RCT was significant(P