ABSTRACT
Objective:To evaluate the clinical efficacy of Chaihu Longgu Muli Decoction in the treatment of post-stroke depression.Methods:A total of 130 patients with post-stroke depression who met the inclusion criteria from April 2019 to December 2020 were enrolled in the study. The patients were randomly divided into two groups with 65 cases in each group. The control group was treated with Flupentixol and melitracen tablets on the basis of routine treatment, and the observation group was treated with Chaihu Longgu Muli Decoction on the basis of routine treatment. Both groups were treated for 4 weeks. TCM syndrome scores were performed before and after treatment. The levels of serum Hcy and hs CRP, Plasma 5-HT and brain-derived neurotrophic factor (BDNF) were detected by ELISA, and the ratio of neutrophils to lymphoblasts (NLR) was recorded.Results:The response rate was 92.3% (60/65) in the observation group and 75.4% (49/65) in the control group. There was significant difference between the two groups ( χ2=6.87, P=0.009). After treatment, the serum Hcy [(11.87±1.56) μmol/L vs. (16.69±1.77) μmol/L, t=16.47] and hs-CRP [(7.81±1.66) mg/L vs. (16.45±4.87) mg/L, t=13.54] in the observation group were significantly lower than those in the control group ( P<0.01), and Plasma 5-HT [(150.41±17.54) μg/L vs. (123.24±16.02) μg/L, t=9.22], BDNF [(19.45±2.48) μg/L vs. (12.56 ± 2.23) μg/L, t=16.66] were significantly higher than those in the control group ( P<0.01). After treatment, the NLR and TCM syndrome scores in the observation group were significantly lower than those in the control group ( t values were 6.03 and 7.15, respectively, all Ps<0.01). Conclusion:The Chaihu Longgu Muli Decoction combined with western medicine treatment can correct the levels of Hcy, hs-CRP, 5-HT, BDNF and NLR in peripheral blood, alleviate the state of depression and anxiety of patients with post-stroke depression.
ABSTRACT
Objective To observe the effect of Chaihu-Longgu-Muli decoction combined flupentixol and melitracen tablets for the post-stroke depression (PSD).Methods The random number table method was used to divide the 150 patients with PSD into the observation group and control group,75 cases in each group.On the basis of conventional treatment of stroke,the control group took oral flupentixol and melitracen tablets,and the treatment group add Chaihu-Longgu-Muli decoction on the basic treatment of control gorup.The treatment of two groups last 1 month.The serum APN concentration was detected before and after treatment.Besides,the HAMD,NIHSS scores,and the clinical curative effect were observed and compared.Results The total effective rate of the observation group was 81.3％,and control group was 58.7％,which the difference between the two groups showed the statistical significance (P＜0.05).After treatment,the serum APN (7.8 ± 3.7 mg/L vs.6.1 ± 3.3 mg/L,t=2.970) level in the observation group was significantly higher than that in the control group (P＜0.05).The HADM (16.4 ± 3.6 vs.19.6 ± 4.9,t=4.558),NIHSS (5.0 ± 1.6 vs.7.7 ± 2.0,t=9.129) scores in the observation group were significantly lower than those in the control group (P＜0.01).Conclusions The Chaihu-Longgu-Muli decoction combined flupentixol and melitracen tablets can reduce the serum APN level of PSD patients,improve patients with depression,alleviate patients' neurologic deficits.
ABSTRACT
Objective: To study the efficacy network and potential mechanisms of effects of Chaihu Longgu Muli Decoction in the treatment of essential hypertension by using network pharmacology methods. Methods: TCMSP, TCMID, and Stitch were used to obtain the components and their corresponding targets. PubMed, CTD, TTD, OMIM, and DrugBank were used to search disease targets of essential hypertension. The common targets between components and disease targets were screened and builded the “compound - target” efficacy network and the protein-protein interaction network by STRING and Cytoscape. The key components and core targets of Chaihu Longgu Muli Decoction in the treatment of hypertension were screened in these networks. Finally, relevant software was applied to GO analysis and pathway analysis of core targets to predict potential mechanisms. Results: A total of 137 components of Chaihu Longgu Muli Decoction and 168 targets of essential hypertension were screened. According to the analysis, quercetin, β-sitosterol, kaempferol, and stigmasterol were found as the four key components and 12 core targets such as IL-6, AKT1, and MAPK8 were found involving the Chaihu Longgu Muli Decoction-induced treatment of essential hypertension. The result of GO analysis and KEGG pathway analysis showed that the mechanisms of Chaihu Longgu Muli Decoction for treating essential hypertension were related to pathways such as activation of AP-1 family transcription factors, interleukin-10 signaling, interleukin-4 signaling, interleukin-13 signaling, the intrinsic pathway of apoptosis, and MAPK targeting/by MAP kinase-mediated nuclear events. Conclusion: The mechanisms of the effect of Chaihu Longgu Muli Decoction in the treatment of essential hypertension were through the above-mentioned “multi-components-multi-targets-multi-pathways”. This study provides a foundation for further investigation of the effective compound and specific mechanisms of Chaihu Longgu Muli Decoction in the treatment of essential hypertension.
ABSTRACT
Objective To observe influences of Chaihu-Longgu-Muli decoction (CLMD) on electroencephalogram (EEG),serum nerve growth factor (NGF) and brain derived neurotrophie factor (BDNF) level of patients with temporal lobe epilepsy.Methods Single blind randomized controlled trial design was used.138 patients with temporal lobe epilepsy were divided into oxcarbazepine group (including 67 patients),oxcarbazepine + CLMD group (including 71 patients).After 28 d of treatment,EEG changes,NGF and BDNF changes in serum,and relevant serological indicator inspection of drug reactions in both groups were observed.Results The effective rate of EEG in oxcarbazepine + CLMD group was 81.8％,which was obviously higher than the oxcarbazepine group (50.7％),with significant difference (P ＜0.01).After treatment,NGF and BDNF of both groups were higher than those before treatment (P ＜0.05).Moreover,serum NGF and BDNF of oxcarbazepine + CLMD group were higher than the oxcarbazepine group (P ＜ 0.05).There was no statistical significance in serological indicator of drug reactions in both groups (P ＞0.05).Conclusions The curative effects of oxcarbazepine + CLMD is superior to the individual oxcarbazepine and it can obviously enhance serum NGF and BDNF of patients with temporal lobe epilepsy and reduce the status epilepticus of patients with temporal lobe epilepsy and it has the high safety.
ABSTRACT
Objective@#To observe influences of Chaihu-Longgu-Muli decoction (CLMD) on electroencephalogram (EEG), serum nerve growth factor (NGF) and brain derived neurotrophie factor (BDNF) level of patients with temporal lobe epilepsy.@*Methods@#Single blind randomized controlled trial design was used. 138 patients with temporal lobe epilepsy were divided into oxcarbazepine group (including 67 patients), oxcarbazepine+ CLMD group (including 71 patients). After 28 d of treatment, EEG changes, NGF and BDNF changes in serum, and relevant serological indicator inspection of drug reactions in both groups were observed.@*Results@#The effective rate of EEG in oxcarbazepine+ CLMD group was 81.8%, which was obviously higher than the oxcarbazepine group (50.7%), with significant difference (P<0.01). After treatment, NGF and BDNF of both groups were higher than those before treatment (P<0.05). Moreover, serum NGF and BDNF of oxcarbazepine+ CLMD group were higher than the oxcarbazepine group (P<0.05). There was no statistical significance in serological indicator of drug reactions in both groups (P>0.05).@*Conclusions@#The curative effects of oxcarbazepine+ CLMD is superior to the individual oxcarbazepine and it can obviously enhance serum NGF and BDNF of patients with temporal lobe epilepsy and reduce the status epilepticus of patients with temporal lobe epilepsy and it has the high safety.
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect difference betweendecoction combined with acupuncture at back-points and simpledecoction for chronic fatigue syndrome.</p><p><b>METHODS</b>Sixty patients were randomly assigned into an herbal group and a combination group, 30 cases in each one. Simpledecoction was used in the herbal group for continuous one month, one decoction a day. Based on that in the herbal group, 30 min acupuncture was used in the combination group at bilateral Xinshu (BL 15), Feishu (BL 13), Pishu (BL 20), Ganshu (BL 18) and Shenshu (BL 23), with acupoints according to syndrome differentiation. Acupuncture was given for 3 courses, 10 times as a course with 3 days between two courses, once a day. Fatigue status was evaluated before and after treatment by fatigue scale 14 (FS-14) and self-rating anxiety scale (SAS).</p><p><b>RESULTS</b>The FS-14 scores, including body fatigue scores, mental fatigue scores and total scores, and SAS scores after treatment were lower than those before treatment in the two groups (all<0.01), with better improvements in the combination group (all<0.01).</p><p><b>CONCLUSION</b> decoction combined with acupuncture at back-points can improve chronic fatigue syndrome, which are better than simpledecoction.</p>