Analysis of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids（CLIPPERS） in 2 Cases and literatures review / 中风与神经疾病杂志

@#To Invetigate chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids （CLIPPERS）clinical diagnosis、the imaging manifestations and the course of treatment to raise the awareness of the disease. Methods To retrospectively analyse clinical diagnosis、the imaging manifestations and the course of treatment of 2 patients with CLIPPERS. Results One patient’s Brain MRI having long T1 and slightly longer T2 signal，not significantly high signal in the DWI，in the brain stem、basal ganglia and cerebellar hemisphere. Another patient had long T1 and slightly longer T2 signal，not significantly high signal in the DWI，in the brain stem and cerebellar hemisphere. Two patients’brain MRI with gadolinium foci of enhancement with a curvilinear pattern highly. Theirs’ magnetic resonance vascular examination were normal. Theirs’symptoms and imagings had improving significantly after glucocorticosteroid shocking treatment. One patient relapsed with long-term oral prednisone，after the second glucocorticosteroid shocking，with long-term oral prednisone and glucocorticosteroids，he had obviously improvement. So far，the patient only uses oral azathioprine，he is well. Another patient died of pneumonia for a week after leaving hospital. Conclusion CLIPPERS syndrome has obviously imaging findings on MRI，and having to get better after glucocorticosteroid treating，prompting CLIPPERS syndrome may be a syndrome of heterogeneous etiology，not an independent disease.

A case report of CLIPPERS syndrome and literature review / 中国脑血管病杂志

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids(CLIPPERS syndrome) is a chronic central nervous system inflammatory disease with sensitivity to steroid therapy. It mainly involves the pons and sometimes other sites. It is relatively rare,and diagnosed by the special sign of 'pepper-salt-like enhancement' in the head magnetic resonance imaging combining other clinical examinations. It should be differentiated from diseases with similar imaging changes. Steroid therapy can effectively relieve the clinical symptoms. The authors report a case of CLIPPERS syndrome that mainly involving cerebellum and spinal cord,and that will be helpful for the understanding of this disease.