ABSTRACT
The main aim of the present study was to evaluate analgesic and CNS depressant activity of methanolic extracts of stem and roots of Cissus pallida and aerial parts of Cissus vitegenia in experimental animals. The analgesic activity was evaluated by Eddy’s hot plate method and CNS depressant activity was evaluated by using digital actophotometer. The study was carried out by using two different doses (200 and 400mg/kg body weight) of both the extracts. The preliminary pharmacological screening showed that both the extracts showed moderate analgesic activity and significant CNS depressant activity.
ABSTRACT
Sesbania grandiflora, a plant of Fabaceae is full of various pharmacologically important components like, alkaloids, flavanoids, tannins, triterpenes, gums, mucilage, and anthraquinone glycosides. From different previous research documents, various functions of different parts like leaf, flower, seed and also other parts of the plant have been known. For this experiment the leaf extract is used. Basically, the objective of the research work was to bring out the pharmacological effects (CNS and analgesic activity) of the leaf extract of the plant. The investigations had brought out the significant effects of extract. Hence, CNS depressant and analgesic drug can be produced from the leaf of Sesbania grandiflora through a suitable formulation.
ABSTRACT
Sesbania grandiflora, a plant of Fabaceae is full of various pharmacologically important components like, alkaloids, flavanoids, tannins, triterpenes, gums, mucilage, and anthraquinone glycosides. From different previous research documents, various functions of different parts like leaf, flower, seed and also other parts of the plant have been known. For this experiment the leaf extract is used. Basically, the objective of the research work was to bring out the pharmacological effects (CNS and analgesic activity) of the leaf extract of the plant. The investigations had brought out the significant effects of extract. Hence, CNS depressant and analgesic drug can be produced from the leaf of Sesbania grandiflora through a suitable formulation.
ABSTRACT
The ethanolic leaf extract of Cymbidium aloifolium (L.) was intended to evaluate the effect on the central nervous system (CNS) using a number of neuropharmacological experimental models in mice. The extract, at the dose of 200 and 400 mg/kg body weight, were shown to have CNS depressant activity by the reduction of locomotor and exploratory activities in the open field and hole cross tests. These results suggest that the extract possess CNS depressant activity. The results of statistical analysis showed that the plant extract had significant, (p<0.001) dose dependent, CNS depressant activities when compared to the control.