CNS side-effect of fexofenadine, 180 mg tablet.

Fexofenadine, the derivative of terfenadine, has been shown to produce no side-effect on the heart, not distributed to the central nervous system (CNS), and having high selectivity for peripheral histamine H1-receptors. Fexofenadine is an effective antihistamine for the treatment of many allergic diseases. The authors have studied the CNS depressant effects of a higher dose of Fexofenadine, a 180 mg tablet, in 20 normal Thai volunteers, 10 males and 10 females with ages ranging from 25 to 52 years, using a double blind cross-over placebo controlled design by comparing it with chlorpheniramine 4 mg tablet. The test methods were both subjective and objective, i.e., visual analogue scale, alertness rating scale, card sorting test, glassbead picking test, and recording of the reaction time to light stimulation. Neither the fexofenadine 180 mg tablet nor the placebo caused any CNS side-effects. However, the chlorpheniramine 4 mg tablet caused significant CNS side-effects.

CNS side effect of fexofenadine, A new antihistamine.

Fexofenadine, derivative of Terfenadine has been proved to be not distributed to the CNS, having high selectivity for peripheral histamine H1-receptors. Fexofenadine is an effective antihistamine for the treatment of many allergic diseases. The authors have studied the CNS depressant effects of Fexofenadine in 20 nomal Thai volunteers; 10 males, 10 females, age ranged 25 to 52 years, using the double blind cross-over placebo controlled design comparing with chlorpheniramine. The test methods were both subjective and objective i.e. visual analogue scale, alertness rating scale, card sorting test, glassbead picking test, recording of the reaction time test for light stimulation. There is no CNS side effect caused by Fexofenadine as well as placebo. Chlorpheniramine caused significant CNS side effects.

Study of the CNS side effect of loratadine, a new antihistamine.

Loratadine, a derivative of the known antihistamine, Azatadine has been proved to be scarcely distributed to the CNS, having high selectivity for peripheral histamine H1-receptore, hence lacking of CNS depressant effects. Lortadine is an effective antihistamine for the treatment of many allergic diseases. The authors have studied the CNS depressant effects of Loratadine in 35 normal Thai volunteers; 17 males, 18 females, age ranged 20 to 40 years, using a double blind cross over placebo controlled design comparing with chlorpheniramine. The test methods were both subjective and objective i.e. visual analogue scale, alertness rating scale, card sorting test, glassbead picking test, recording of the reaction time test for light stimulation. The CNS side effects of loratadine proved to be differ from those caused by placebo and significantly less than the CNS depressive effect by chlorpheniramine.