ABSTRACT
Background: To retrospectively determine the correlation between CTseverity score & D-dimer. Methodology: This is retrospective original research of 227 patients (IPD & OPD) during April 1 to May 31, 2021 for Covid-19. Patients CTseverity scores, HRCTThorax findings, D-dimer, Platelet count and Demographic variables were recorded. The correlation between CTseverity score & D-dimer were determined. Results:Between the mentioned dates, 227 patients are taken into study which includes 146 Males & 81 Females. Mean of CTseverity score was 6.7, D-dimer was 0.46mg/l. Higher CTscore is seen in males (mean -7.1) as compare to females (mean -6.12). D-dimer are seen higher in males (mean =0.52mg/l) as compare to females (median=0.37mg/l). The study of 227 patients has shown positive correlation between CTscore & D-dimer (r=0.38, p<0.05). Males showed relatively stronger positive correlation (r=0.4, p<0 .05) than females (r=0.3, p<0.05). Patients with age less than equal to 45 has shown relatively stronger positive correlation between CTscore & D-dimer (r=0.4, p<0.05) than patients with age more than 45 (r=0.35, p<0.05). Conclusion:Pulmonary lesion induced by SARS-CoV-2 infection was associated with raised inflammatory response, impairment in exchange of gases, and end organ damage. In study, we can conclude that lung lesion may exert important role in COVID-19 pathogenesis & clinical presentation
ABSTRACT
Introduction: The surge of Covid -19 pandemic and the earlier depletion of resources have led to the need of allocation of patients based on levels of risk. The COVID 19 related mortality has been on increase in people with old age, male gender, infiammatory markers elevation and in people with history of co morbidities. With this background, thus study aimed to observe association between CRP, D-Dimer, Serum Ferritin, The Initial CT Chest Severity Score and the outcome of Covid 19 in patients with Type 2 Diabetes mellitus. A hospital based retrospective study was done among COVID 19 patie Materials and methods: nts from the period of September to December 2020. Patients with Type 2 diabetes mellitus admitted with RT-PCR positive (or) CT Thorax – CORADS 4 and above with age more than 18 years and having CRP, D-Dimer, Serum Ferritin results within 24 hours after admission were included in the study. The data was collected using a semi structured questionnaire. A total of 531 individuals were participa Results: ted in the study. The mean respiratory rate and oxygen saturation between the survived and deceased groups was statistically significant (p value 0.024 and 0.044 respectively). All the patients had normal blood urea and serum creatinine values. The mean CORADS score of the participants is 4.78 ± 0.60. There is statistically Conclusion: significant difference in the mean respiratory rate and mean SPO2 between deceased and recovered patients. With advancements in medical sciences, it may not be a rigid process to predict severity with laboratory investigations
ABSTRACT
Background: Coronavirus disease 2019 (COVID-19) pandemic has adversely affected the human health and wealth across the globe and is still posing a serious challenge to us. In the armamentarium of various drugs approved for COVID-19, remdesivir proved to be a major breakthrough in the treatment of moderate-to-severe cases. Our study is regarding its clinical efficacy and safety in hospitalized reverse transcription polymerase chain reaction (RT-PCR) confirmed adult patients with moderate-to-severe COVID-19 disease. Material and methods: A total of 100 patients with moderate-to-severe COVID-19 (RT-PCR positive) admitted in the intensive care unit (ICU) of Sri Krishna Medical College and Hospital (SKMCH), Muzaffarpur, Bihar, were enrolled in the study from 12th August to 11th November, 2020. All patients were given injection remdesivir as 200 mg IV loading dose on Day 1, followed by 100 mg IV daily for next 4 days along with other standard treatment. Results: Out of total 100 patients, 88 patients recovered and were discharged, while 12 patients died. Mean age of patients was 54 ± 16 years with male preponderance (4:1). Mean duration of hospital stay was 10.6 ± 5.4 days. C-reactive protein, D-dimer, ferritin and interleukin-6 decreased significantly after treatment with remdesivir, with p value <0.01, as compared to values at the time of admission, without any significant side effects. Conclusion: Early administration of remdesivir helps contribute to better clinical outcome in moderate-to-severe COVID-19 disease, without any significant side effects.