ABSTRACT
The corpus callosum is the largest white matter tract in the human brain, and its specific function is still unclear. Corpus callosum infarction is clinically rare, and its manifestations are complex and diverse. It is easy to miss and misdiagnose early. Corpus callosum infarction is often accompanied by other parts infarction, and the incidence of the infarction at the splenium of corpus callosum is the highest. Isolated corpus callosum infarction can be characterized by typical disconnection symptoms, such as apraxia, tactile disorder, Alien hand syndrome, visual deformity, etc. The prognosis of the corpus callosum infarction is generally better. This article reviews the etiology, clinical manifestations, imaging, differential diagnosis, and research status of treatment of corpus callosum infarction.
ABSTRACT
Callosal disconnection results in the functional independence of each hemisphere and usually produces characteristic signs including alien hand, left-sided apraxia, left agraphia and left tactile anomia. Our two patients; a 75-year-old right-handed woman with hypertension and a 71-year-old right-handed woman with diabetes mellitus, showed impairments in the identification of body parts with their left hands in addition to characteristic symptoms such as left ideomotor apraxia, agraphia, tactile anomia, and right alien hand signs with groping and grasping. Brain MRIs of these patients upon admission demonstrated infarcts in the medial portion of the left frontal lobes and in the corpus callosum supplied by the left anterior cerebral artery. The impairment of body parts cognition in our patients can be attributed to the failure of the patient's left hand to communicate with the body schema stored in the left hemisphere.