ABSTRACT
Objective To develop chemotherapy training system for new nurses in cancer special hospital and to provide related references.Methods The initial chemotherapy training system for new nurses in cancer special hospital was developed by literature review.Two rounds of expert consultation were conducted among 22 experts from 14 cities in China via Delphi Technique to finalize the training system.Results The recovery rates were 100.00％ and 90.90％,and the authority coefficients were both 0.82,coordination coefficients of two rounds of consultation were statistically significant by chi-square test (P＜0.01),the coefficient of variation of each item ranged from 0.00 to 0.21 in the second round.The chemotherapy training system consisted of 6 first-level indicators,13 second-level indicators and 50 third-level indicators.Conclusion The study methods were scientific,experts had high level of enthusiasm and authority,and had agreed opinions for each indicator of the developed chemotherapy training system for new nurses in cancer special hospital which can be used for training new nurses.
ABSTRACT
Objective To evaluate endoscopic ultrasonography (EUS) for TN restaging and predicting response to advanced gastric cancer after neoadjuvant chemotherapy. Methods A total of 22 patients,15 males and 7 females, mean age 64 (36-80 years ), with advanced gastric cancer were recruited to the study from June 2007 to December 2009 with written informed consents. All patients underwent 3 cycles of neoadjuvant chemotherapy ( Folfox 6 ), and subsequent surgery ( R0 resction) in 3-4 weeks after chemotherapy. EUS was performed 1-2 weeks before and 1-2 weeks after chemotherapy. EUS TN staging was compared with pathological findings. The correlation of peri-chemotherapy EUS TN staging with postoperative pathological response was evaluated. Results After chemotherapy, the overall accuracy of EUS T staging was 63.6% (14/22), with overstaging (36. 4%, 8/22) more frequent than understaging (0). The overall accuracy of N staging was 54. 5% (12/22) with 4 ( 18. 2%, 4/22) overstaging and 6 ( 27. 3%, 6/22 ) understaging. EUS revealed T and/or N downstaging ( concyrrence of T and N downstaging was accounted once) after chemotherapy in 10 patients, with 9 T downstaging (4 from T3 to T2, 5 from T4 to T3) and 4 N downstaging (4 from N1 to N0). TN downstaging was correlated with pathological response, with 7 patients achieving pathological response 2 and 1 patient 3. Conclusion T and N restaging by EUS after neoadjuvant chemotherapy in patients with locally advanced gastric cancer is not accurate enough. However, T and/or N downstaging confirmed by EUS is well correlated with a better degree of pathological response to chemotherapy.