The value of tumor markers in monitoring of non-small cell lung cancer / 中华全科医师杂志

One hundred and four patients with non-small cell lung cancer (NSCLC) and 17 patients with benign lung lesions were enrolled in the study. Carcinoembryonic antigen ( CEA), neural specific enolaee (NSE) and cytokemtin 19 fragment (CYFRA21-1) in serum were detected by dectruchemiluminescence method before and after operation. The serum levels of three markers in preoperative NSCLC patients were significandy higher than those of benign pulmonary diseases group (t = 7. 930, 5.568, 6. 110, P <0. 05) ; but there were no significant differences between postoperative NSCLC patients and benign disease patients (t = - 0.034, 1. 242, 0.691, P > 0.05 ). There were significant differences in serum levels of CEA, NSE and CYFRA21-1 before and after operation in NSCLC group ( t = 5.419, 4.722, 5.779, P < 0.05 ) ; but not in benign pulmonary disease group ( t = - 1.244, 0.732, 1. 000, P >0.05). This study indicates that detection of serum CEA, NSE and CYFRA21-1 is of monitoring value for treatment of non-small cell lung cancer.

The rapeutic effect of Shengrong Capsule with combinations of chemotherapy in treatment of advanced non-small-cell lung cancer / 肿瘤研究与临床

Objective The observation Shengrong Capsule union chemotherapy treatment to a treatment invalid non-small-cell lung cancer curative effect and the poisonous side reaction.Methods Using Shengrong Capsule to unite other commonly used chemotherapy medicine compositions the union ehemotheraPY plan to treat the non-small-cell lung cancer 68 examples to observe its curative effect and the poisonous side effect.Results Treatment group in the near future alleviating rate 89.2%,comparison group 70.1%;Symptom improvement rate:The treatment group 81.5%,the comparison group is 53.9%;The white blood cell descending rate treatment group is 29.0%,the comparison group is 41.9%;The blood platelet descending rate treatment group is 29.0%,the comparison group is 48.4%;Statistics processing has the remarkable difference(P＜0.05).Conclusion This group of materials demonstrated Shengrong Capsule joinfly to treat the non-small cell lung cancer with other chemotherapy medicines to obtain 89.2% alleviating rate,also can the obvious blood and the non-system a sanguineum poisonous side reaction,Shengrong Capsule be is effective,economical and safe.

Surgical Treatment for T4 Non-small Cell Lung Cancer Invading Mediastinal Structures / 대한흉부외과학회지

BACKGROUND: Non-small cell lung cancer (NSCLC) with invasion of mediastinal structures is classified as stage IIIB, and has been considered surgically unresectable. However, in a selected group of these patients, better results after surgical resection compared to non-surgical group have been reported. The aim of this study is to evaluate the role of surgical resection in treatment of mediastinal T4 NSCLC. MATERIAL AND METHOD: Among 1067 patients who underwent surgical intervention for non-small cell lung cancer from Aug 1987 to Dec 2001 in Korea cancer center hospital, 82 patients had an invasion of T4 mediastinal structures (7.7%). Resection was possible in 63 patients (63/82 resectability 76.8%). Their medical records in Data Base were reviewed, and they were followed up completely until Jun 2002. Surgical results and prognostic factors of NSCLC invading mediastinal structures were evaluated retrospectively. RESULT: Lung cancer was resected completely in 52 patients (63.4%, 52/82). Lung resection was lobectomy (or more) in 14, pneumonectomy in 49. The mediastinal structures invaded by primary tumor were great vessel (61.9%), heart (19%), vagus nerve (9.5%), esophagus (7.9%), and vertebral body (7.9%). Nodal status was N0 in 11, N1 in 24, and N2 in 28 (44.4%). Neoadjuvant therapy was done in 6 (9.5%, 5 chemotherapy, 1 radiotherapy), and adjuvant therapy was added in 44 (69.8%, 15 chemotherapy, 29 radiotherapy) in resection group (n=63). Complication was occurred in 23 (31.7%), and operative mortality was 9.5% in resection group. Median and 5 year overall survival including operative mortality was 18.1 months and 21.7% in resection group (n=63), 6.2months and 0 % in exploration only group (n=19, p=.001), 39 months and 32.9% in N2 (-) resection group (n=35), and 8.8 months and 8.6% in N2 (+) resection group (n=28, p=.007). The difference of overall survival by mediastinal structure was not significant. CONCLUSION: The operative risk of NSCLC invading mediastinal structures was high but acceptable, and long-term result of resection was favorable in selected group. Aggressive resection is recommended in well selected pateints with good performace and especially N2 (-) NSCLC with mediastinal invasion.

Clinical Significance of the Aortic Node in Non-small Cell Lung Cancer of the Left Upper Lobe / 대한흉부외과학회지

BACKGROUND: To clarify the clinical significance of the aortic nodes in resected non-small cell lung cancer of the left upper lobe. MATERIAL AND METHOD: One hundred fifty six patients with resected non-small cell lung cancer of the left upper lobe were studied. Patients who received preoperative induction therapy, non-curative operation or defined as operative mortality were excluded from this study. RESULT: In N2 left upper lobe tumors, aortic nodes comprised 52.7% of the metastatic mediastinal lymph nodes. In single station N2 disease, a frequently metastasized station was aortic node (64.3%). 5-year actuarial survival according to the N status was 65.0% in N0, 30.4% in N1, and 17.9% in N2. There was no statistically significant difference in survival between N1 and N2 diseases (p=0.06). The patients with metastasis to aortic node alone had a comparatively good prognosis (5-year survival: 35.6%) than other N2 diseases (5-year survival: 4.6%) (p=0.01) and had a similar survival outcome as N1 diseases (p=0.97). Considering the aortic node as N1 node, 5-year survival according to the N status was 65.0% in N0, 31.2% in N1, 4.6% in N2 and significant survival difference was observed between N1 and N2 disease (p=0.00). In multivariate analysis, the male sex (hazard ratio 6.892, p=0.011) and the involvement to the aortic node alone (hazards ratio 2.799, p=0.009) were the significant factors affecting postoperative survival. CONCLUSION: According to the our data, involvement to the aortic node alone in left upper lobe tumors should be grouped with N1 disease because this combined category reflects the surgical outcome more accurately.