ABSTRACT
Objective: Since acetazolamide is a carbonic anhydrase inhibitor, it presents relevant aspects with regardto the treatment of late reimplanted teeth, and therefore, this is the aim of the present literature review.Data Sources: The databases used were Pubmed and Bireme. Selection of works: was performed usingthe keywords Tooth reimplantation, Dental ankylosis, Acetazolamide and Carbonic anhydrase inhibitors.Conclusions: In spite of contemporary guidelines for the treatment of late reimplantation, there is still avery high loss of avulsed teeth due to resorption, particularly by replacement resorption, so that the searchfor new substances or means of treatment is of the utmost importance.
Objetivo: Uma vez que a acetazolamida é uma inibidora da anidrase carbônica, ela apresenta aspectos relevantesquanto ao tratamento de dentes reimplantados tardiamente, justificando assim o objetivo da presenterevisão de literatura. Fontes de dados: as bases de dados utilizados foram Pubmed e Bireme. Seleção dos damtrabalhos:foi realizada por meio das palavras-chave Reimplante dentário, Anquilose dentária, Acetazolamidae Inibidores da anidrase carbônica. Conclusões: Apesar das diretrizes atuais para o tratamento do reimplantetardio, ainda a perda de dentes avulsionados por reabsorção é muito alta, principalmente diante da reabsorçãopor substituição, sendo premente a busca por novas substâncias ou meios de tratamento.
Subject(s)
Humans , Acetazolamide/therapeutic use , Carbonic Anhydrase Inhibitors/therapeutic use , Tooth Replantation/methods , Tooth Resorption/drug therapy , Feasibility Studies , Treatment OutcomeABSTRACT
X-linked juvenile retinoschisis (XLRS) is a recessively inherited vitreoretinal degeneration characterized by macular pathology and splitting of the neuroretinal layers that is associated with alterations in the XLRS1 gene. There have been no therapeutic interventions known to be effective for patients with X-linked juvenile retinoschisis, but some studies are trying to determine the importance of dorzolamide for the treatment of foveal lesions in this disease. The authors, using optical coherence tomography, describe findings in a patient with X-linked juvenile retinoschisis, before and after a topical use of dorzolamide. Besides the improvement in his visual acuity, further studies are required to elucidate the real prevalence of nonresponse to dorzolamide and the frequency with which there may be a recurrence of foveal cystic changes during continued treatment.
A retinosquise juvenil ligada ao X (XLRS) é uma degeneração vítreo-retiniana hereditária e recessiva caracterizada por lesão macular e delaminação das camadas de fibras nervosas da retina, que está associada com alterações no gene XLRS1. Nenhuma intervenção terapêutica tem se mostrado efetiva em pacientes com retinosquise juvenil ligada ao X, mas alguns estudos estão tentando determinar a importância da dorzola mida no tratamento das lesões foveais desta doença. Os autores, usando a tomografia de coerência óptica, descrevem os achados em um paciente com retinosquise juvenil ligada ao X, antes e após o uso de dorzolamida tópica. Apesar da melhora na acuidade visual do paciente estudado, outros estudos são necessários para uma melhor elucidação da real prevalência dos pacientes não responsivos ao tratamento com dorzolamida, bem com a recorrência das lesões císticas a longo prazo.
Subject(s)
Child , Humans , Male , Antihypertensive Agents/administration & dosage , Retinoschisis/drug therapy , Sulfonamides/administration & dosage , Thiophenes/administration & dosage , Administration, Topical , Retinoschisis , Time FactorsABSTRACT
Alteration of the chemical composition of aqueous humor may be closely related to the occurrence of glaucoma. Comparison of chemical composition of aqueous humor in glaucoma patients with that of the normal eyes is thought to be helpful in searching the pathogenesis and treatment modality of glaucoma. Concentration of 8 chemical components in the aqueous humor of cataract eyes as well as glaucoma eyes was analyzed and the differences between the two groups were searched by the authors. Subjects were 47 eyes of 47 cataract patients and 35 eyes of 32 glaucoma patients. During the operation 0.1-0.2cc of aqueous humor was collected by anterior chamber paracentesis and 10cc of blood was also drawn. In cataract patients, the mean values were Na+;145.2, K+;4.0, Cl-;123.7, HCO3-; 22.9 mEq/l, Ca++;6.6, Mg++;1.7, glucose; 48.2 mg/100 ml and ascorbic acid; 245.5 microgram/ml. In glaucoma patients, the mean values were Na+;142.1, K+;4.0, Cl-;126.0, HCO3-;17.6 mEq/I, Ca++;6.3, Mg++;1.9, glucose; 59.4 mg/100 ml and ascorbic acid; 227.5 microgram/ml. Aqueous glucose concentration was 55% of blood glucose level, and aqueous ascorbic acid concentration was 62 times higher than that in blood. Regarding the eight components in aqueous humor, no significant difference was found between cataract and glaucoma patients. Lack of significant difference in ascorbic acid levels between the two groups was thought to be due to the use of carbonic anhydrase inhibitors prior to glaucoma surgery.