ABSTRACT
@#Hydrogen sulfide(H2S)is an endogenous gas messenger molecule with extremely broad biological activities including vasodilation, anti-oxidation, anti-inflammation, cardioprotection and anti-tumor. Similar to other gas messenger molecules, the biological activity of H2S is dependent on its location, concentration and duration of exposure. Therefore, the key scientific issue is how to improve the selectivity of H2S donor molecules to release appropriate concentrations of H2S at the target site(commonly pathological place), exerting therapeutic efficacy with limited side-effects. This article reviews the structures and H2S release mechanisms of two classes of H2S donors focusing on the advances in the recently developed H2S donors with controllable release potential of H2S, thus providing new ideas for future H2S-based drug research.
ABSTRACT
Volatile sulfur compounds ( VSCs) in the marine environment has significant implications for global climate change. In the present study, a gas chromatographic analytical method was set up to determine the concentrations of VSCs in seawater and atmosphere, and the optimized experimental conditions were established. For the analysis of VSCs in atmosphere, multistage traps and gas chromatography-mass spectrometry ( GC-MS ) were used, with the precisions of 7. 7% -15. 1% and the detection limits of 0. 23-4. 7 ng. Moreover, for the analyses of VSCs in seawater, pre-concentration and gas chromatography coupled with flame photometric detector ( GC-FPD) were utilized, with the precisions of 3. 5%-5. 3% and the detection limits of 2. 5-3. 5 ng. This method was applied to analyze the VSCs in Qingdao coastal seawater and atmosphere, and the average concentrations of carbonyl sulfide, dimethyl sulfide and carbon disulfide in the seawater were (268 ± 58 ) , ( 1264 ± 278 ) , ( 19 ± 2 ) pmol/L, and ( 543 ± 39 ) , ( 29 ± 9 ) , ( 56 ± 20 ) ( ×10-12 , V/V) in the atmosphere, respectively.
ABSTRACT
Volatile sulfur compounds ( VSCs) in the marine environment has significant implications for global climate change. In the present study, a gas chromatographic analytical method was set up to determine the concentrations of VSCs in seawater and atmosphere, and the optimized experimental conditions were established. For the analysis of VSCs in atmosphere, multistage traps and gas chromatography-mass spectrometry ( GC-MS ) were used, with the precisions of 7. 7% -15. 1% and the detection limits of 0. 23-4. 7 ng. Moreover, for the analyses of VSCs in seawater, pre-concentration and gas chromatography coupled with flame photometric detector ( GC-FPD) were utilized, with the precisions of 3. 5%-5. 3% and the detection limits of 2. 5-3. 5 ng. This method was applied to analyze the VSCs in Qingdao coastal seawater and atmosphere, and the average concentrations of carbonyl sulfide, dimethyl sulfide and carbon disulfide in the seawater were (268 ± 58 ) , ( 1264 ± 278 ) , ( 19 ± 2 ) pmol/L, and ( 543 ± 39 ) , ( 29 ± 9 ) , ( 56 ± 20 ) ( ×10-12 , V/V) in the atmosphere, respectively.