ABSTRACT
RESUMEN El cáncer colorectal es el tercer tipo de neoplasia maligna más frecuentemente diagnosticada para ambos sexos. El adenocarcinoma es el tipo histológico que constituye el 86% de todos los casos de carcinoma colónico; sin embargo, existen otros subtipos menos frecuentes, como el carcinoma adenoescamoso, una neoplasia sumamente rara, pero con peor pronóstico y menor sobrevida. Presentamos el caso de una paciente mujer de 68 años con un tiempo de enfermedad de 2 años, caracterizado por anemia, hematoquezia y dolor abdominal. El estudio colonoscópico reveló la presencia de tumoración a nivel de colon ascendente, el cual luego de la resección quirúrgica y estudios anatomopatológicos, resultó corresponder a un carcinoma adenoescamoso primario colónico.
ABSTRACT Colorectal cancer is the third most frequently diagnosed cancer in both men and women. Adenocarcinoma is the most common pathologic subtype of colon cancer and constitutes 86% of all colon cancers. Nontheless, there are other less frequent sybtyes of colorectal carcinomas, such as adenosquamous carcinoma, an extremely rare form of colon cancer, but with worse prognosis and greater potential of metástasis. We present the case of a 68-year-old female presented with a two-month history of anemia, hematochezia and abdominal pain. The colonoscopic study presented a tumor in the ascending colon, which after surgical resection and pathological studies, turned out to be a primary colonoc adenosquamous carcinoma.
ABSTRACT
ABSTRACT Adenosquamous carcinoma of the pancreas (ASCP) is a rare variant of the pancreatic ductal adenocarcinoma (PDAC). Between 2004 and 2016, four cases of ASCP were resected at our institution; clinicopathological data were collected. All of our patients were males, aged 55-80 years. Three cases were cephalic tumors; and one, pancreatic tail tumor, measuring between 2.3 and 5.5 cm. All had neurovascular invasion and lymphatic metastasis. Two had retroperitoneal positive margins. The overall survival (OS) after surgery was three weeks-42 months. Prognosis of ASCP is dark and OS appears to be more closely related to surgical margins status than to other clinicopathological factors.
RESUMO O carcinoma adenoescamoso pancreático (ASCP) é uma variante rara do adenocarcinoma ductal (PDAC). Entre 2004 e 2016, foram ressecados quatro casos de ASCP em nossa instituição, com registro dos dados clínicos e patológicos. Os pacientes eram homens entre 55 e 80 anos. Três tumores eram cefálicos; e um, caudal, com dimensões variáveis entre 2,3 e 5,5 cm. Todos tinham invasão neurovascular e metástases linfáticas; dois, margens cirúrgicas retroperitoneais positivas. A sobrevida global (SG) pós-cirurgia foi de três semanas a 42 meses. O prognóstico do ASCP é sombrio, com SG aparentemente mais relacionada com o status das margens cirúrgicas do que com outro fator clinicopatológico.
ABSTRACT
El carcinoma adenoescamoso primario de la vesícula biliar es una variante poco conocida e infrecuente de este tipo de neoplasias, cuya etiología y comportamiento siguen constituyendo un enigma. Se trata de una paciente de 45 años de edad con un carcinoma adenoescamoso primario de vesícula biliar; se presenta este caso por ser un reto diagnóstico debido a lo poco que se conoce sobre esta entidad, la cual es considerada más agresiva y de peor pronóstico que el adenocarcinoma en su presentación clásica.
Adenosquamous carcinoma of the gallbladder is a little-known and infrequent variant of carcinoma, and its etiology and behavior are not completely known. In this review we present a patient of 45 years with a primary adenosquamous carcinoma of the gallbladder, a case that is reported for being a diagnostic challenge for an uncommon entity, which is considered more aggressive and of worse prognosis than the adenocarcinoma in its classical presentation.
Subject(s)
Humans , Gallbladder , Carcinoma , Carcinoma, Adenosquamous , Gallbladder NeoplasmsABSTRACT
El carcinoma adenoescamoso primario de vesícula biliar (CAEVB), es una neoplasia infrecuente cuya etiología y comportamiento biológico no están totalmente aclarados. Describimos un caso de un paciente masculino con un carcinoma adenoescamoso infiltrante primario de vesícula biliar diagnósticado en una colecistectomía por colelitiasis. Morfológicamente se encontró asociado a los elementos glandulares y escamosos malignos, la presencia de displasia de bajo y alto grado del epitelio glandular y metaplasia escamosa entre las zonas glandulares y escamocelulares, que permiten hacer el diagnostico de este tipo de carcinoma. El estudio de inmunohistoquímica mostraba marcadores tanto de diferenciación glandular como escamosa. Por tratarse de una variante infrecuente de Carcinoma de vesícula biliar reportamos este caso por las dificultades que genera su diagnóstico. Nuestras observaciones sugieren que se trata de un adenocarcinoma con áreas de metaplasia escamosa y posterior transformación maligna de los elementos escamosos.
The adeno-squamous gallbladder carcinoma is a frequent neoplasm with blurred etiology and biological course. A case report is presented from a male with an incidental finding of a gallbladder carcinoma diagnosed during a cholecystectomy. Associated to malignant glandular and squamous morphological findings, low grade dysplasia and squamous metaplasia were observed, allowing the final diagnosis. Immunohistochemistry analyses revealed both glandular and squamous differentiation biomarkers. The report of a rare gallbladder carcinoma illustrates difficulties for proper diagnosis. The analysis suggests an adenocarcinoma with squamous metaplasia areas that evolved towardsthe malignant transformation of squamous components.