ABSTRACT
PURPOSE: Histologically, IPMN (intraductal papillary mucinous neoplasm) includes various grades of lesion, from hyperplasia and adenoma to adenocarcinoma. The prognosis is different for each histological grade. The malignant IPMN contain in-situ and invasive carcinoma. The purpose of this study was to investigate the clinicopathologic features and outcome of invasive IPMN. METHODS: 18 patients with invasive IPMN underwent surgical treatment between October 1994 and December 2005 at Samsung Medical Center. The clinical, biochemical and pathologic features were retrospectively analyzed. Survival and the clinicopathologic features were compared between invasive IPMN and PDAC of the well differentiated type (wd, n=27) and carcinoma in-situ (CIS, n=10). RESULTS: The preoperative CA19-9 level and total bilirubin level of invasive IPMN patients was statistically higher than those of the CIS patients. The tumor size of invasive IPMN was larger than that of PDAC (wd) (P=0.038). The median survival of patients with invasive IPMN was 31.0 month. The 5-year survival rates of patients with PDAC (wd) and invasive IPMN were 35.5% and 41.7%, respectively (P= 0.237). CONCLUSION: there were no differences for invasive IPMN and PDAC (wd) except for tumor size. The survival in patients with surgical resected invasive IPMN was similar to that of the patients with surgical resected PDAC (wd).
Subject(s)
Humans , Adenocarcinoma , Adenoma , Bilirubin , Hyperplasia , Mucins , Pancreatic Ducts , Prognosis , Retrospective Studies , Survival RateABSTRACT
Objective To study the relativity analysis of abnormal cervical pathology results in cytology and histology.Methods With retrospective analysis of 31,634 cases of fluid-based thin-layer method(ThinPrep Cytology Test,TCT)of PUMC Hospital from January,2001 to March,2003,which reported in the Bethesda System,we checked the abnormal results and advised different diagnose biopsy of vaginoscopy and/or conization,and got the relativity description of abnormal results in TCT and CINⅢ/CIS results validated by vaginoscopy,match analysis of the CINⅡ～Ⅲ and CINⅢ/CIS results validated by vaginoscopy and conization labeled by the age group,and relativity analysis of abnormal results in TCT and CINⅢ/CIS results validated by vaginoscopy.Results Among 31,634 cases of TCT test,948 cases had confirmed biopsy results validated by vaginoscopy,of which 70 cases were of CINⅡ～Ⅲ,56 cases were of CINⅢ/CIS.The risk ratio(RR)of different abnormal TCT results in predicting CINⅢ/CIS results validated by vaginoscopy is:ASCUS group,14.7(95% confidence interval 8.0～27.0,P=0.00);CINⅠ group,13.9(6.3～30.9,P=0.00);CINⅡ group,44.2(15.5～126.5,P=0.00);CINⅢ group,272.2(161.6～458.6,P=0.00);Cancer group,unmeasured.As noted,there is no significant difference between the RR of ASCUS group and CINⅠ group(P=0.951)in predicting CINⅢ/CIS results.Conclusions Vaginoscopy examination and biopsy could verify histology abnormity of CINⅡ～Ⅲ及CINⅢ/CIS from abnormal results of TCT,and has a good accordance along with biopsy results of conization.There are significantly greater risk of being CINⅢ/CIS validated by vaginoscopy in the abnormal TCT patients,among which ASCUS group and CINⅠ group have the coequal risk.