ABSTRACT
OBJECTIVES@#To study the effect of vaccination on the short-term risk of immunoglobulin A vasculitis (IgAV) in children.@*METHODS@#A retrospective analysis was conducted on the general data and the vaccination history within one year prior to onset in children with IgAV hospitalized in the Children's Hospital Affiliated to Zhengzhou University from November 2021 to January 2023. Vaccine exposure rates in the risk period (3 months prior to IgAV onset) and the control period were compared by autocontrol-case crossover analysis, and the odds ratio and 95% confidence interval (95%CI) were calculated. A sensitivity analysis for the one-month and two-month risk periods was conducted.@*RESULTS@#A total of 193 children with IgAV were included, with a median age of 7.0 years. Among the 193 children, 36 (18.7%) received at least one dose of the vaccine within 1 year prior to IgAV onset, and 14 (7.3%) received at least one dose of the vaccine during the 3-month risk period. Compared to the unvaccinated IgAV group, the vaccinated IgAV group had a significantly younger age of onset (P<0.05). There were no significant differences in the proportions of children with gastrointestinal involvement, renal involvement, and joint involvement between the two groups (P>0.05). The odds ratio for developing IgAV after receiving any type of vaccine within 3 months prior to IgAV onset was 2.08 (95%CI: 0.82-5.27, P>0.05). Further sensitivity analysis for the 1-month and 2-month risk periods demonstrated that the odds ratios for developing IgAV after receiving any type of vaccine were 2.74 (95%CI: 0.72-10.48, P>0.05) and 2.72 (95%CI: 0.95-7.77, P>0.05), respectively.@*CONCLUSIONS@#Vaccination dose not increase the risk of IgAV, nor does it exacerbate clinical symptoms in children with IgAV.
Subject(s)
Humans , Child , Retrospective Studies , Immunoglobulin A , IgA Vasculitis , Vaccination , VaccinesABSTRACT
Objective To assess the association of air pollution and preterm birth in Taiyuan.Methods The preterm birth data from November 2005 to January 2007 were from Taiyuan birth surveillance system,meteorological data and air pollution data were from Shanxi Meteorological Bureau and Taiyuan Environmental Monitoring Station respectively.The case-crossover analysis and conditional Logistic regression model were used to analyze the association of air pollution and preterm birth in Taiyuan,while the meteorological factors were controlled.Results The stronger effective period of PM10 was 5-day lag and 6-day lag,of SO2 was 7-day lag and 8-days moving average.When PM10,SO2 increased 50 ?g/m3,for PM10,the OR of a 5-day lag and a 6-day lag were 1.169(95%CI:1.058～1.292),1.235(95%CI:1.115～1.367)respectively,for SO2,the OR of a 7-day lag and a 8-days moving average were 1.346(95%CI:1.122～1.616),2.203(95%CI:1.517～3.201)respectively.In sensitivity analysis,the lagged effects of PM10 and the cumulative effects of SO2 were steady.Conclusion The air pollution in Taiyuan may produce an acute effect on preterm birth.
ABSTRACT
Objective To assess the association of air pollution with daily mortality among residents of Zhabei district in Shanghai. Methods Case,crossover analysis and conditional Logistic regression model were used to analyze the association of air pollution with daily mortality of residents in Zhabei district of Shanghai from June 2000 to December 2002. Results Using a symmetric bi,directional control sampling approach, the results obtained from a conditional logistic regression model with four reference periods after controlling for weather conditions showed that the OR of non,accidental mortality associated with each 10 ?g/m3 increment of PM10, SO2 and NO2 over a 48,hr moving average were 1.007(95%CI 1.003-1.011),1.011(95%CI 1.001-1.021),1.010(95%CI 1.000-1.020)respectively. Similar associations were observed between mortality of cardiovascular diseases and PM10, mortality of respiratory diseases and NO2. Also, PM10 was associated with mortality in a sensitivity analysis. Conclusion The acute effect of air pollution on mortality of the general population was established in Zhabei district of Shanghai.