ABSTRACT
Objective To study the tumor suppression of Chinese caterpillar fungus water decoction combined cisplatin on a tumor burdened mice .Methods The beforehand vaccinal HCT8 tumor burdened mice were randomly devided into 5 groups(n=10) ,then 3 groups of Chinese caterpillar fungus water decoction were given a tumor burdened mice stomach (2 .5 ,5 .0 ,10 g/kg) ,1 times a day ,12 d .1 group of mice were given saline .1 group were given cisplatin .Determination of different concentrations of cordyceps water decoction lavage ,then observe the changes of tumor‐burdened bone tumors in mice weight .Results For vaccination HCT8 tumor burdened bone tumors had an average weight of each dose group mice compared with saline group have significant difference(P<0 .01) ,while Chinese caterpillar fungus water decoction (2 .5 ,5 .0 g/kg) and cisplatin group mice tumor block is more significant difference(P< 0 .01) ,the tumors had the lighter weight .Conclusion Chinese caterpillar fungus water decoction has tumor suppression effect on tumor burdened mice .
ABSTRACT
The ADR reports of Chinese Caterpillar Fungus and its preparations were retrieved through CNKI database and further analyzed. It was found that their adverse actions were mainly allergic responses involved with urinary system, endocrine system, and gastrointestinal system simultaneously. Specification should be stipulated on the use of Chinese Caterpillar Fungus and its preparations.
ABSTRACT
Chronic renal failure is clinical syndrome manifested as hypoactivity of renal function that can be caused by manifold diseases. CRF is difficult to be treated and has bad prognosis. In recent years, according TCM physiological and pathological mechanism, doctors have achieved good effects in preventing and delaying CRF in its early and middle stage by adopting the therapeutic principle of expelling toxin, strengthening body resistance, and promoting blood circulation to dissipating blood stasis.
ABSTRACT
This study was carried out to identify the phylogenetic relationships among several caterpillar fungi by comparing the sequences of internal transcribed spacer regions (ITS1 and ITS2) and 5.8S ribosomal DNA (rDNA) repeat unit. The sequences of ITS1, ITS2, and the 5.8S rDNA from 10 strains of Cordyceps species, 12 strains of Paecilomyces, 3 strains of Beauveria, 2 strains of Metarhizium and 1 strains of Hirsutella were amplified, determined and compared with the previously known Cordyceps species. The sequences of 5.8S rDNA were more conserved in length and variation than those of ITS regions. Although the variable ITS sequences were often ambiguously aligned, the conserved sites could be found. In the phylogenetic tree, the species generally divided into three clusters, supported by their morphology and/or host ranges. The 5.8S rDNA and ITS1 sequences among 10 species of Cordyceps militaris were identical and only one base pair in ITS2 sequence was different. Cordyceps sinensis and Cordyceps ophioglossoides were also clearly different, although they belonged to the same cluster. The GenBank database search of species revealed sister taxa of an entomogenous fungus. Metarhizium was used as an outgroup in all taxa.