ABSTRACT
Contexte & objectif. L'hépatite virale B (HVB) par son évolution peut déboucher vers la guérison ou vers une forme chronique qui est très peu documentée chez les donneurs bénévoles de sang (DBS). L'objectif de la présente étude était de déterminer la prévalence de l'HVB chronique. Méthodes. L'étude réalisée au Centre National de Transfusion Sanguine de Bangui était rétrospective et portait sur les données de contrôle sérologique des DBS de Bimbo et de Bangui, capitale de la République centrafricaine (RCA). L'échantillonnage exhaustif concerne la période de juillet 2013 à décembre 2019. Le DBS est porteur d'une infection chronique si l'antigène de surface de l'HVB persiste pendant plus de six mois. Le test de Chi carré de Pearson au seuil de 5 % et l'odd ratio (OR) ont été utilisés comme test d'association. Résultats. Les données de contrôle sérologique de 702 DBS âgés de 18 à 62 ans ont été analysées. Le sexe masculin était prépondérant (n=598). La prévalence de l'HVB chronique était de 70,5 %. Cette prévalence était plus élevée chez les DBS de 25 à 34 ans (30,4 %), les hommes (58,8 %) et les DBS qui résident à Bangui (61,2 %). La forme chronique était significativement associée au jeune âge (18 à 44 ans) et au sexe masculin (p< 0,05). La coïnfection par le VIH et l'hépatite C était retrouvée dans 5,5 % des cas (39/702). Conclusion. La prévalence de l'HVB chronique est très élevée chez les DBS de Bangui et Bimbo. La forme chronique était significativement associée à l'âge et au sexe. La gratuité de la charge virale et du traitement antiviral sont des perspectives à mettre en Åuvre
Context and objective. Viral hepatitis B (VHB) by its evolution can lead to recovery or to a chronic form. This chronic form, a source of new contaminations, is not documented among voluntary blood donors (VBD) in Bangui and Bimbo. The present study aimed to determine the prevalence of chronic VHB among VBD in the two cities in the Central African Republic (CAR). Methods. The study carried out at the Bangui National Blood Transfusion Center was retrospective and focused on serological control data from VBD from Bangui, capital of CAR and Bimbo. The exhaustive sampling is from July 2013 to December 2019. A VBD carries a chronic infection if the VHB surface antigen persists for more than six months. Results. Serological control data from 702 VBD aged 18 to 62 years were analyzed. Male sex predominated at inclusion (n = 598). The prevalence of chronic VHB was 70.5 %. This prevalence was higher among young VBD aged 25 to 34 years (30.4 %), the male gender (58.4 %) and VBD residing in Bangui (61.2 %). The chronic form was significantly associated with young age (18 to 44 years) and male sex (p< 5%). Co-infection with HIV and hepatitis C was found in 5.5 % of cases (39/702). Conclusion. The prevalence of chronic VHB is very high in VBD from Bangui and Bimbo. The chronic form was significantly associated with age and sex. Free viral load and antiviral treatment are prospects to be implemented.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Blood Donors , HIV Infections , Hepatitis B, Chronic , Hepatitis B , CoinfectionABSTRACT
<b>Background</b><br> According to the state of the world's children 2006, 28% of children under five years of age in sub-Sahara Africa are malnourished, which has serious effects on these children's health and lives. <br> Extensive research has been conducted on child malnutrition in a variety of developing countries. These studies have established scientific indexes to lead and coordinate international action to assist the needy. Central African Republic, however, has been a blind spot. Therefore, the present study was conducted in order to clarify the nutritional status and associated factors of 6 to 24-month-old children in the district of Boy-rabe, Bangui, Central African Republic.<br><b>Methods</b><br> Participants were mothers with children aged 6-24 months who visited either a government-run clinic or the NGO-run clinic, Amis d'Afrique, between August 26th and September 16th of 2006. Mothers were interviewed using a structured questionnaire and measurements of the children's weight and length were collected. Weight, length, and age data were compared with child growth standards proposed by the WHO to calculated z-scores for evaluatinglength-for-age (wasting), weight-for-length (stunted growth), and weight-for-age (underweight). The following factors were investigated for their association to malnutrition in children: “demographic characteristics”, “access to food”, “maternal and child-care practices”, and “poor water/sanitation and inadequate health services”.<br><b>Results</b><br> A total of 126 mother-child pairs participated in this study and valid data from 109 pairs were subjected to analysis. The rates of wasting, stunted growth, and underweight children were 20.2%, 61.5% and 42.2%, respectively.<br> Incomplete vaccination (p=0.043) and the mother not having a partner (p=0.046) were significantly associated with wasting. Stunted growth was found to be associated with older child's age (p<0.001), older mothers' age (p=0.005), mothers who had stopped breast-feeding (p=0.031), insufficient breast-feeding (p=0.032), mothers with child death experience (p=0.022), mothers with a number of delivery experiences (p=0.026) and mothers with a partner (p=0.042). Underweight children were associated with incomplete vaccination (p=0.043) and mothers with child death experience (p=0.046).<br><b>Conclusion</b><br> In total, 8 factors were found to be significantly associated with child's malnutrition and household/family level. In particular, severe acute malnutrition, or wasting, was related to insufficient vaccination, while chronic malnutrition, or stunted growth, was significantly associated with breast-feeding.