Eventos adversos del nimotuzumab en pacientes con tumor cerebral primario / Adverse events to the nimotuzumab in patients with primary cerebral tumor

Introducción: El nimotuzumab es un anticuerpo monoclonal empleado en el tratamiento de pacientes con tumor cerebral. Dada su novedad se justifica la realización de estudios de farmacovigilancia que avalen su seguridad. Objetivo: Caracterizar los eventos adversos relacionados con este medicamento en la práctica médica habitual. Métodos: Se realizó un estudio descriptivo y transversal de 41 pacientes con tumor cerebral primario tratados con nimotuzumab en el Departamento de Ensayos Clínicos del Hospital Provincial Docente Saturnino Lora Torres de Santiago de Cuba, desde mayo de 2017 hasta abril de 2019. Resultados: En la serie se identificaron 31 eventos adversos, de los cuales 17 eran conocidos y 14 desconocidos. Predominaron la cefalea (80,5 %), la debilidad en miembros inferiores (48,8 %) y la fosfatasa alcalina elevada (41,5 %). Cabe destacar que el total de los efectos no deseados se consideraron ligeros, según su intensidad; reversibles, según sus resultados y sin cambios, según la actitud respecto al medicamento. Conclusiones: Las características de los eventos adversos encontrados se asemejan a las descritas en otros estudios que también avalan la seguridad del fármaco.

Introduction: The nimotuzumab is a monoclonal antibody used in the treatment of patients with cerebral tumor. The realization of pharmaco surveillance studies that guaranteed its security is justified given its new features. Objective: To characterize the adverse events related to this medicine in the habitual medical practice. Methods: A descriptive and cross-sectional study of 41 patients with primary cerebral tumor treated with nimotuzumab in the Clinical Trial Department of Saturnino Lora Torres Teaching Provincial Hospital was carried out in Santiago de Cuba, from May, 2017 to April, 2019. Results: In the series 31 adverse events were identified, of which 17 were known and 14 were unknown. There was a prevalence of the headache (80.5 %), weakness in lower members (48.8 %) and the high alcaline phosphatase (41.5 %). It is necessary to highlight that all the non wanted effects were considered light according to the intensity; reversible, according to the results and without changes, according to the attitude regarding the medicine. Conclusions: The characteristics of the adverse events that were found resemble to those described in other studies that also guarantee the security of the drug.

Professor ZHANG Yonghong's Clinical Experience in Treatment of Cerebral Tumor / 浙江中医药大学学报

[Objective] To explore and analyze Professor ZHANG Yonghong's clinical experience in treating cerebral tumor.[Methods]Through the clinical study with the teacher to collect and collate the relevant information and medical records, from the etiology and pathogenesis of cerebral tumor, governance and other aspects of the specific analysis and discussion on Professor ZHANG Yonghong's treatment of this disease, academic point of view and clinical experience,it summed up the law of condemnation, and to the case of evidence,through regular follow-up, observing the treatment effect. [Results]Professor ZHANG Yonghong views that the pathogenesis of cerebral tumor can be summarized as Qi deficiency, phlegm and blood stasis, internal movement of the liver, and confusion of the body. Its pathologic factors are related to wind, fire, phlegm, blood stasis and poison. In the treatment of cerebral tumors, it is advocated to improve Qi, nourish Yin, promote positive Qi, and break loose to remove cancer toxins. On the basis of the selection of invigorating the spleen and protecting the stomach, the rational use of invigorating the Qi and nourishing the Yin and combining with the drugs of eliminating evils and removing toxin, in order to achieve the goal of strengthening the anti -cancer. The two cases both achieved good results by strengthening the body resistance, eliminating evils and removing toxin.[Conclusion]Professor ZHANG Yonghong stressed that strengthening of the body resistance is a primary treatment when the treatment for cerebral tumor. We should pay attention to replenishing Qi and nourishing Yin, eliminating evils and removing toxin are adjuvant therapy. The spleen and stomach should be protected throughout the treatment, and patient's mood are also important. It is of great significance to instruct TCM to treat cerebral tumor.

Research advances in dual-targeting nanocarrier-based delivery system for the treatment of brain diseases / 中国药学杂志

RESULTS: The drug carrier was modified with bifunctional-ligands, which could help the drug delivery system penetrate the blood-brain barrier and concentrate on lesions, thus improving the drug efficacy and reducing the side effects.

Colloid cyst of the third ventricle: imaging findings with pathologic correlation

Colloid cysts of the third ventricle are benign tumors but potentially dangerous, as they frequentlyundergo undiagnosed. Despite being histologically benign, colloid cysts of the third ventricle can obstruct the foramen of Monro and produce intense hydrocephaly. These lesions are known as a major cause of sudden death, underscoring the importance of establishing diagnosis as soon as possible. Computed tomography and Magnetic Resonance are important for diagnosing these cysts. In the present case report, the authors describe the clinical, diagnostic imaging and pathological findings of a 19-year old male, with a 3 cm colloid cyst of the third ventricle. Patient died within few days following complications of obstruction of the foramen of Monro

Quantitative Analysis of Feature Parameter in Brain Tumor CT Perfusion Image / 中国医学物理学杂志

Objective:The abstraction of characteristics in CT perfusion image is crucial in the clinical diagnosis of brain infarction and cerebral tumor.Methods:After describing the relevant parameters of CT cerebral perfusion imaging,such as cerebral blood flow (CBF),cerebral blood volume (CBV),the mean transition time (MTT) and the permeability surface (PS).With using Visual C ++ programming and CT scan images sequence obtained,the time-density curves of the brain tumor region were visualized.The more accurate hemodynamic parameters were calculated through an improved algorithm basing on the deconvolution and measuring method of the length,angle,area and other parameters.Conclusion:The quantitative analysis of feature parameter is of great benefit to clinical doctor in making timely diagnosis and treatment of brain tumor.

Clinical, endocrinological and radiological courses in patients who was initially diagnosed as idiopathic central diabetes insipidus / 소아과

PURPOSE: Idiopathic central diabetes insipidus (CDI) is defined in CDI patients without definite etiology. Some patients initially diagnosed as idiopathic CDI progressed to organic causes. We reviewed clinical, endocrinological, and radiological courses of 20 patients who was initially diagnosed as idiopathic CDI, to assess the predicting factors for progression to brain tumors. METHODS: We reviewed the medical data and followed up their clinical courses in 20 CDI patients who had no definite organic etiology, such as malformation, tumor, at the time of diagnosis. RESULTS: Our study included 15 males and 5 females. Mean age of CDI diagnosis was 7.83.6 (2.1-14.7) years. Mean follow-up duration was 8.65.1 (1.5-18) years. Six (30%) patients were diagnosed as brain tumor during follow-up. Ten (50%) of 20 patients had growth hormone deficiency. Multiple pituitary hormone deficiencies were found more frequently in brain tumor patients than idiopathic patients (60% vs 7%, P=0.037). Pituitary stalk thickening (PST) and loss of posterior pituitary signal were observed in 9 patients (47%), respectively. The newly development of PST was observed in patients diagnosed as brain tumor. CONCLUSION: About 30% of idiopathic CDI patients progress to organic disease such as germ cell tumor or histiocytosis. If there are multiple anterior pituitary hormone deficiency or newly development of PST, more close and careful follow-up is needed.

Resección de lesiones cerebrales en area rolándica con mapeo cortical intraoperatorio* / Resection of brain lesions in rolandic area with intraoperative cortical mapping

Objetivo. Describir los resultados obtenidos con el mapeo cortical intraoperatorio en el tratamiento de los tumores rolándicos. Método. El estudio se realizó en 27 pacientes (mayo 2000 - mayo 2005) entre 27 y 78 años (16M-11F) con tumores intracraneanos ubicados en el área central. En todos los casos se efectuaron técnicas de localización funcional y se utilizaron potenciales evocados somatosensitivos intraoperatorios y estimulación cortical bipolar. Resultados. La resección fue total en 24 casos y subtotal en 3 casos. En los 23 pacientes que presentaban algún déficit motor previo a la cirugía se logró la mejoría en 17 de ellos, permaneciendo estables 5 y sólo 1 caso padeció un empeoramiento transitorio. Ningún paciente sin déficit previo lo padeció después. No se registraron complicaciones relacionadas con el procedimiento de localización. Conclusión. El mapeo cortical intraoperatorio es una técnica segura y confiable para la preservación de la corteza elocuente en la cirugía de tumores del área rolándica.

Objective: To describe the results obtained with intraoperative cortical mapping in the surgical treatment of rolandic tumors. Method: We studied 27 patients (may 2000-may 2005) between 27 and 78 years old (16 males-11 females) with intracranial tumors located in the rolandic area. In all cases we used techniques of functional localization and, intraoperative somatosensorial evoked potentials and bipolar cortical stimulation. Results: In 24 cases removal was total and in 3 cases was subtotal. Of the 23 cases with preoperative motor symptoms, postoperatively 17 were improved, 5 remained stable and 1 deteriorated transiently. No patient without preoperative deficits was worst. We did not have complications related to the localization procedure. Conclusion: Intraoperative cortical mapping is a safe and sound technique for the preservation of the eloquent cortex during surgery of rolandic tumors.

Application of dynamic contrast-enhanced perfusion MR imaging in intracranial tumors / 医学研究生学报

Dynamic contrasted-enhanced perfusion MR imaging can provide noninvasive and physical maps of cerebral microcirculation. The tumor vascularities are assessed by calculating cerebral blood volumes of the normal cerebral tissue and tumor tissue from imaging signal intensities. This technique is helpful to better evaluate the histopathological grade of gliomas, determine the biopsy site for tumors. And it is very useful for the preoperative diagnosis of gliomas, solitary metastases, cerebral lymphomas, as well as differentiating tumor recurrence after surgical resection and radiotherapy from radiation necrosis. But there are some limitations in evaluating extraaxial tumors and cerebral tumors with severe breakdown of blood-brain barrier.

Prognosis factors of cerebral stellate cellular tumor

A study on 21 patients with ages of 5-70 and cerebral stellate cellular tumor has found that the poor prognosis was increased with age, nervous lesion and size of tumor. The tumor in brain had prognosis poorer than this in cerebellum. The treatment involved the operation combining with radiation.

Clinical Significance of Synchronous Detection of ?_2-microglubin and ?-glucuronidase in CSF of Patients With Cerebral Tumor / 中国医师杂志

Objective To study the clinical significance of the content of ? 2-microglubin and activity of ?-glucuronidase in cerebrospinal fluid (CSF) of patients with cerebral tumor. Methods The activities of ? 2-microglubin and ?-glucuronidase in CSF of patients with cerebral tumor and non- cerebral tumor were analyzed by radioimmunoassay and enzyme-linked immunosorbent assay (ELISA) respectively. Results the activities of ? 2-microglubin and ?-glucuronidase in cerebral malignancy were obviously higher than that of cerebral benign tumor (P

Some opinions of some clinical and paraclinical features of the cerebellar potine angle tumors

54 patients with the cerebellar pontine angle tumor in Bach Mai, Viet Duc, Sainfaul, Hai Ba Trung Hospitals during 1/1998 - 10/2001 participated to a study. The results have shown that most of them were acoustic neurinoma 33/54 (61.1%), next to meningioma 10/54 (18.5%) and other tumors included medulloblastoma: 5(9.2%), astroytoma: 2 (3.7%), hemangioblastoma: 2 (3.7%), metastasis tumor: 1 (1,9%) and nerve V tumor 1 (1.9%). The acoustic neurinoma usually progresses slowly and its initial symptoms included tinitus, hearing loss. An imbalance is the first symptom of expansion of the tumor from cerebella to the pontine angle.