ABSTRACT
Due to abstract and intricate theories of TCM theories, its essential characteristics are difficult to master, so the mechanism can be better explored through study on quantification of prescription properties. At present, quantification research by many scholars mainly adopts isolated research model limited to one or several kinds of TCM properties, which is difficult to reveal treatment mechanism of prescriptions. The development of big data and cloud computing technology provides a new way for the deep analysis of massive and complex TCM information. Based on syndrome differentiation, it is trending in prescription quantification to employ a comprehensive analysis by using "four properties - five flavors - channel tropism - ascending and descending, floating and sinking - toxicity -efficacy" overall on macroscopic level to analyze and quantify the characteristics of TCM prescriptions and their relationships among each other. This article reviewed recent research progress in the quantification of prescription properties and provided references for the modernization and specification of quantification of prescription properties.
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[Objective] To summarize treatment ideas for subclinical thyroid inflammation by Professor WU Xuesu.[Methods] By learning from Professor WU Xuesu, studying relevant literature cases;collecting and reporting the case of her clinical characteristics for the treatment of subclinical thyroid inflammation, analyzed and summarized treatment experience. [Results] It is argued that the root of subclinical thyroid inflammation is turbid-phlegm, nitrogen stasis cardiac knoting in the anterior portion, it should be treated by resolving phlegm mainly,and secondary promoting Qi activating blood. [Conclusion] The treatment ideas of Professor WU Xuesu for subclinical thyroid inflammation has a good curative effect.
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Metabonomics as an important component of systems biology, the research idea is similar to the overall concept in the research of traditional Chinese medicine (TCM). In recent years, with the vigorous development of metabonomics, its application is more and more widely in modern research of Chinese material medica (CMM). In this paper, based on the introduction of origin, development, research content, and method of metabonomics, and at the same time its application on medicinal properties in TCM theory, including four Qi, five tastes, meridian entry, direction of medicinal actions (upward, downward, outward, and inward), toxicity, compatibility of medicines, and the contraindication of application, are summarized. The preliminary analysis and sums up of research problems and development trend on the metabonomics applying in TCM property theory have been brought forward.
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Objective: Based on supramolecular imprinting template self-recognition theory, to lay the foundation for the in vitro channel tropism research methods of Chinese materia medica (CMM). Using alizarin as imprinting template feature monomer, in vitro affinity chromatography of different pig organs was performed to test the mechanism of alizarin belonging to the liver meridian. Methods: The liver, lungs, tongue, abdominal muscle, leg muscle groups, and other tissues of pigs, as stationary phases, were made into column chromatography. Using PBS as the mobile phase, in vitro affinity chromatography experiments with alizarin belonging to the liver meridian and white sugar belonging to the spleen meridian were conducted, the content of eluent alizarin was measured by HPLC and the content of sugar was measured by UV. By using the analysis of total statistical moment, the various chromatographic parameters and chromatography equations were obtained. Results: The chromatographic parameters for the alizarin in liver, lungs, tongue, abdominal muscles, leg muscles were as following: C0: 0.2509-4.813 mg/mL; AUC: 2.509-48.13 mg; VR: 20.42-30.77 mL; σ2: 282.6-532.7 mL2; H: 14.13-26.63 mL; n: 1.212-1.777; S: 0.759 0-1.000. In the positive control group, the adsorption capacity of liver for alizarin was the strongest, and abdominal, leg, lungs, and tongue were weakened in turn. While in the negative control group, the adsorption capacity of liver for glucose (white sugar) was not the strongest. Conclusion: The adsorption capacity of liver for alizarin is the strongest, and liver has an affinity for alizarin by the super molecular imprinting templates, and it matches the theory of meridian belonging to the liver, which would establish the in vitro channel tropism preliminary research methods of CMM.
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Objective: To observe the in vivo tissue distribution of 6-gingerols, 6-shogaol, and 8-gingerols from dried ginger (the rhizome of Zingiber officinale) in rats and to discuss the channel tropism of them. Methods: The method of "symptoms-efficacy-pharmacokinetics" was used and the ginger solution was ig given to the rats which were deficiency-cold in spleen and stomach; Then the blood, heart, liver, spleen, lung, kidney, brain, stomach, large intestine, and small intestine were immediately taken out after the rats were ig given the medince in 10, 20, 40, 60, 80, 120, and 360 min, respectively; Finally, HPLC was used to detect the concentration of 6-gingerols, 6-shogaol, and 8-gingerols from dried ginger in different tissues of rats in each group of deficiency-cold in spleen and stomach and normal by calculating the pharmacokinetic parameters. Results: We found that in the group of deficiency-cold in spleen and stomach, the concentration of the three active components was the highest in stomach, small intestine, liver, and lung, and in the group of normal, the three components were mostly distributed in the stomach, kidney, small intestine, large intestine, and lung. What's more, in the digestive organs, such as stomach and small intestine, the concentration was obviously higher in the group of deficiency-cold in spleen and stomach than that in the group of normal. Conclusion: The main ingredients of dried ginger mostly distribute in spleen, stomach, lung, and liver. This view conform to the traditional channel trpism of dried ginger in traditional Chinese medicine theory.
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Objective To analyze the rules of property of the drugs used by State Medical Master Yan Zhenghua in clinical.Methods The prescriptions used by Pro. Yan were collected to build a database, which was based on traditional Chinese medicine inheritance assistant software. After analyzed by the software, such as using the module to analyze the prescriptions, the medication characters of the prescriptions can be got from the database.Results Drugs of warm nature were used with the highest frequency 7998 times, followed by the cool 7866 times, leveling 6763 times, cold 3942 times, and hot 95 times. From the property of five flavors, the most used flavor of drugs was bitter 15260 times, followed by sweet 10810 times, pungent 10453 times, sour 2794 times, salty 1651 times, mild 1203 times, and astringency 186 times. In the frequency of the channel tropism involved, the highest is of liver channel 14237 times, followed by lung 10452 times and spleen 10061 times.Conclusion Pro. Yan was accustomed to using the drugs that were of warm and cool natures, and sweet and pungent flavors, and also the drugs that have action on the collateral channels of liver, lung and spleen, which were the same as the experience from Pro. Yan.
ABSTRACT
Chloasma is a common pigmentation on facial skin among middle-aged or young women. The characteris-tic of chloasma is acquired brown spots on exposed facial regions. Modern traditional Chinese medicine (TCM) clini-cal treatment mostly follows syndrome differentiation and treatment as well as prescriptions of TCM doctors from pre-vious dynasties. On the basis of different facial location of chloasma, the author explored the correlation between the facial lesion location and five zang-organ under the guidance of TCM holism concept. The creativeness of combining division differentiation and channel pattern differentiation, and the application of channel tropism medicine, provide new ideas for chloasma treatment.