ABSTRACT
Objective: To analyze the difference of chemical constituents in the different parts of Schisandrae Fructus (SF) for researching regularities of their distribution and try to provide the basis for reasonable application of different parts of SF. Methods: An ultra-high performance liquid chromatography coupled with time of flight mass spectrometry (UPLC-Q-TOF/MS) was carried out to acquire the chemical constituents information in samples with different parts of SF. High precise mass data were processed by multivariate statistical analysis techniques to discover and identify the constituents with significant difference. Results: A total of 29 compounds were identified and 23 compounds were lignans. The differences of chemical constituents among the three parts of SF could be obviously observed by the method of OPLS-DA in positive mode. There were 14 chemical ingredients of lignans with significant differences identified by comparison with retention time and mass spectra. Conclusion: The chemical constituents of lignans are mainly distributed in the seed and this study provides the basis for clinical reasonable application of different parts of SF.