ABSTRACT
Objective:To screen the main active components of Danggui Buxue Decoction in improving chemotherapy-induced myelosuppression; To predict the key targets and signaling pathways; To establish a multi-level network structure and comprehensively reveal the synergistic mechanism of Danggui Buxue Decoction in improving chemotherapy-induced myelosuppression.Methods:Main components of Danggui Buxue Decoction were searched in TCMSP detabase, combined with literature reports to supplement and improve information. The protein targets of compounds were standardized in the UniProt protein database. Myelosuppression targets were obtained by querying TTD database, GeneCards database, DrugBank detabase and OMIM database. The effective components and common targets of Danggui Buxue Decoction were screened, and the protein-protein interaction (PPI) network of intersection targets was analyzed by String platform to construct the PPI network of effective components and disease targets. Gene ontology (GO) analysis and enrichment pathway analysis of Kyoto gene and genome encyclopedia (KEGG) of key target proteins were conducted through Metascape data platform. Both the results of GO and KEGG analysis were presented. AutoDock software was used for molecular docking to explore the interaction between core targets and active components, and the results were imported into PyMOL software for visual analysis.Results:Danggui Buxue Decoction has a total of 22 active components of Chinese materia medica for improving chemotherapy-induced myelosuppression, 294 potential targets, 3 301 disease targets, and 210 common targets of Chinese materia medica and diseases. Core targets were obtained through network topology analysis and molecular docking. The first five were ESR1, MAPK1, RELA, AKT1, PIK3R1; GO enrichment results obtained 2 430 biological processes, 125 cellular components and 217 molecular functions, including responses to inorganic substances, membrane rafts, micro-organisms membrane region, transcription factor binding, etc.; KEGG enriched 385 pathways, of which cancer pathway, PI3K-Akt signaling pathway, AGE-RAGE signaling pathway, etc. were the main signaling pathways; molecular docking results showed that β-sitosterol has the best binding performance with HSP90AA1, formononetin and RELA in astragalus when it was in Angelicae Sinensis Radix.Conclusion:Danggui Buxue Decoction regulates ESR1, MAPK1, RELA, AKT1 and other core targets through various active components such as quercetin, formononetin, and β-sitosterol. PI3K-AKT and other related signaling pathways can improve chemotherapy-induced myelosuppression and provide a basis for its clinical application.
ABSTRACT
Objective To observe the effect of salt-partitioned moxibustion at Zhongwan (CV12) in treating belching due to chemotherapy.Method Subjects with chemotherapy-induced belching were randomized into an observation group and a control group, 30 in each group. The control group was intervened by intramuscular injection with Ritalin 20 mg, while the observation group was by salt-partitioned moxibustion at Zhongwan for 30 min in addition to the intramuscular injection.Result The total effective rate was 93.3% in the observation group versus 76.7% in the control group, and the difference was statistically significant (P＜0.05); the action latency in the observation group was (1.7±1.8)min in the observation group versus (15.6±4.2)min, and the difference was statistically significant (P＜0.01).Conclusion Salt-partitioned moxibustion at Zhongwan is significantly effective in treating chemotherapy-induced belching, and it’s easy-to-operate, efficient, and safe.
ABSTRACT
El presente estudio titulado: "Validación de una Guía de cuidados para el manejo y control de los efectos secundarios post quimioterapia según la opinión de enfermeros en el Servicio de Especialidades Médicas y Quimioterapia", tuvo como objetivo determinar la Validación de una guía de cuidados para el manejo y control de los efectos secundarios post quimioterapia según la opinión de enfermeros. Material y Método: El estudio es de nivel aplicativo, tipo cuantitativo, método descriptivo de corte transversal. La población estuvo conformado por 20 enfermeros, la técnica fue la encuesta y el instrumento fue la guía de cuidados y un opinionario aplicado previo consentimiento informado Resultados: Del 100 por ciento (20), 70 por ciento (14) tienen una opinión favorable y 30 por ciento (6) no favorable. Conclusión: La Validación de la guía de cuidados según la opinión de la mayoría de enfermeros es favorable, en cuanto al contenido y estructura, lo cual permitirá brindar información importante del paciente oncológico en tratamiento con quimioterapia sobre los efectos secundarios post quimioterapia...
This study entitled: "Validation of a care guide for the management and control of the side effects post chemotherapy according to nurses at the service of medical specialties and chemotherapy", aimed to determine the validation of a care guide for the management and control of side effects post chemotherapy according to nurses. Material and method: The study is application level, quantitative, descriptive cross-sectional method. The population was comprised of 20 nurses, the technique was the survey and instruments a care guide and an opinionario applied prior informed consent results: 100 per cent (20), 70 per cent (14) have a favorable opinion and 30 per cent (6) not favorable. Conclusion: The validation of the care guide according to the opinion of the majority of nurses is favorable, in terms of content and structure, enabling you to provide important information for the cancer patient in treatment with chemotherapy side effects post chemotherapy...
Subject(s)
Nursing Care , Rebound Effect , Practice Guideline , Drug Therapy , Evaluation Studies as Topic , Cross-Sectional StudiesABSTRACT
Objective: To retrospectively investigate the relationship between plasma concentration of fluorouracil and its therapeutic efficacy as well as adverse reactions in 70 patients with locally advanced or metastatic gastric cancer, and to determine the role of pharmacokinetic monitoring of fluorouracil in improvement of efficacy and reduction of adverse reactions of fluorouracil-based chemotherapy. Methods: Seventy patients with unresectable locally advanced or metastatic gastric cancer were randomly assigned into group A [treated with DCF regimen (docetaxol+cisplatin+fluorouracil), repeated every three weeksfor at least four cycles] and group B [treated with DOF regimen (docetaxol+oxaliplatin+fluorouracil), repeated every three weeks for at least four cycles]. The plasma concentration of fluorouracil was detected by high performance liquid chromatography (HPLC) (time for detection: 4-6 AM) after continuous infusion of fluorouracil over 12 h in each cycle. The average value of plasma concentrations in each cycle was calculated, and the factors related to plasma concentration of fluorouracil were screened by stepwise regression. Then all patients were divided into three groups (group 1, group 2 and group 3) according to the predictive confidence interval of plasma fluorouracil concentration, and the average values of plasma fluorouracil concentration in each cycle of these three groups were less than or equal to 25.5 mg/L25.6-37.4 mg/L, and more than 37.4 mg/L, respectively. The relationship between plasma concentration of fluorouracil and its therapeutic efficacy as well as adverse reactions was retrospectively analyzed. Results: Stepwise regression analysis showed that the plasma concentration of fluorouracil was associated with myelosuppression, mucositis, progression-free survival (PFS) and overall survival (OS). The average plasma concentrations of fluorouracil in group 1, group 2 and group 3 were (20.73±3.80) mg/L, (31.98±3.10) mg/L and (40.32±3.45) mg/L, respectively (χ2=66.24, P <0.001). As for efficacy, the medianPFS and OS of group 2 and group 3 were both significantly higher than those of group 1 [PFS: (6.00±0.32), (7.50±0.75) and (4.50±0.19) months, χ2=2.09, P <0.001; O S: (13.00±1.58), (12.50±2.66) and (8.50±1.00) months, χ2=32.32, P <0.001]. In terms of adverse reactions, the incidence rates of bone marrow suppression and mucositis of group 3 were both higher than those of group 1 and group 2 (P =0.04 and P =0.03). Conclusion: The patients with advanced gastric cancer receiving fluorouracil-based chemotherapy with an average plasma concentration of fluorouracil maintained within the range of 25.6-37.4 mg/L can obtain better survival and tolerance as well as lower incidence rates of adverse reactions such as myelosuppression (especially III/IV), mucositis, etc. Copyright© 2011 by TUMOR.