ABSTRACT
Objective: To screen angiogenesis inhibitor from 26 drugs for promoting blood circulation and removing blood stasis through chick chorioallantoic membrane(CAM)model in vivo.Methods: The experimental groups were 26 drugs for promoting blood circulation and removing blood stasis.Tablets,capsules,pills and powder of the drugs were adopted in the form of saturated concentration,decoction was in the form of concentration of 2g/ml,and injection,oral liquid and electuary were in their own concentration.7-day-old fertilized white chicken eggs incubated at 37℃ in chamber were prepared by creating a window in the shell.A sponge carrier was placed on CAM and treated with different liquid medicine with the dosage of 20?l per egg daily for 3 days.On day 10,the number of CAM blood vessel embranchment 5mm around the carrier was counted with a stereomicroscope.Results: 15 drugs for promoting blood circulation and removing blood stasis obviously inhibited the CAM blood vessels(P