ABSTRACT
Abstract This research explores the mediational role of mental health in the relationship between early adverse experiences and current self-reported delinquency in young adults with past juvenile justice involvement. Seventy-five young adults with official records of juvenile delinquency in 2010/2011 filled out our protocol in 2014/2015 including the Adverse Childhood Experiences (ACE) questionnaire, the Brief Symptom Inventory, and the D-CRIM questionnaire (evaluating delinquency). The global level of adverse experiences during childhood and adolescence was related to mental health problems and self-reported delinquency in young adulthood, while psychopathological symptoms were also related to current self-reported delinquency. The mental health indicator partially mediated the link between early adversity and current self-reported offending in individuals with past juvenile justice involvement. Our results are in line with previous psychological and neurobiological approaches and highlight the importance of mental health services in youth offender rehabilitation. Future directions for research are provided.
Resumo Esta pesquisa explora o papel mediador da saúde mental na relação entre experiências adversas precoces e delinquência autorreportada em jovens adultos com historia de envolvimento no sistema de justiça juvenil. Setenta e cinco jovens adultos com registros de delinquência juvenil em 2010/2011 preencheram o protocolo em 2014/2015, incluindo o Questionário de Experiências Adversas na Infância, o Inventário de Sintomas Psicopatológicos e o D-CRIM (que avalia a delinquência). O nível global de experiências adversas na infância e adolescência associou-se tanto a problemas de saúde mental como à delinquência autorreportada em jovens adultos, os sintomas psicopatológicos estiveram também associados à delinquência juvenil no presente. O indicador de saúde mental parcialmente mediou a relação entre adversidade precoce e o nível atual de delinquência em indivíduos com história de envolvimento no sistema de justiça juvenil. Os nossos resultados estão em linha com abordagens psicológicas e neurológicas prévias e salientam a importância dos serviços de saúde mental na reabilitação de jovens ofensores. Direções futuras são apresentadas.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Criminals/psychology , Adverse Childhood Experiences/statistics & numerical data , Juvenile Delinquency/psychology , Mental Health Services/organization & administration , Mental Health , Surveys and Questionnaires , Risk Factors , Self Report , Juvenile Delinquency/rehabilitationABSTRACT
Objective To explore the effect of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism,environmental factor and their interactions on antidepressant treatment.Methods 340 patients of major depressive disorder (MDD) who met the diagnosis criteria of MDD ( DSM-Ⅳ Axis Ⅰ) were recruited.280 patients of them were finished 12 weeks antidepressant treatment.The severity of depression was measured with the Hamilton Depression Rating Scale (HDRS) before and after 12 weeks antidepressant treatment.Childhood Trauma Questionnaire,28-item Short Form (CTQ-SF) and Life Events Scale (LES) were used to evaluate childhood adverse and life stress before onset.Genotyping of BDNF Val66Met polymorphism was detected by Illumina GoldenGate assays.Results Male patients proportion were significantly higher in non-remitters than remitters (P =0.008 ).After adjusting by gender, the frequencies of genotype and allele for the BDNF Val66Met polymorphism were no significant difference between remitters (AA: AG: GG = 28: 79: 40, A:G = 135:159 ) and non-remitters (AA: AG: GG = 29:81:23 ,A: G = 139:127 ) (P ＞0.05 ).There was no significant difference of CTQ scores and LES scores between the two groups (P＞0.05 ).The regression analysis showed that social intercourse problem and age were the risk factor for the severity of depression.The gender, HDRS baseline scores and mental disorder family history were associated with the efficacy of 12 weeks antidepressant.However,there was no significantly relationship between the interaction of BDNF Val66Met polymorphism and environment with the antidepressant treatment.Conclusion The older men with the mental disorder family history, severe depression symptom would be less-response to antidepressant treatment.However, BDNF Val66Met polymorphism, childhood trauma, life events stress and the interaction of BDNF Val66Met polymorphism and environment have no significantly effect on the 12 weeks antidepressant treatment.