ABSTRACT
Objective To explore the application value of Chinese brain template Chinese2020 in resting-state functional magnetic resonance imaging (rs-fMRI) data analysis of Chinese Alzheimer disease (AD) patients. Methods Twelve Chinese AD patients (AD group) and 17 healthy volunteers (control group) were collected. Then rs-fMRI data were registered to the Chinese brain template Chinese2020 and traditional standard brain template ICBM152, respectively. Whole brain analysis was performed to explore the regional spontaneous neuronal activity alterations in AD patients, in which amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were extracted as indicators. The distribution pattern of brain regions with significant differences obtained from the data analysis based on the two templates was compared respectively. Results The results from both templates showed that ALFF in AD group decreased in right superior temporal gyrus, right precuneus and right angular gyrus while increased in left cerebellum, left temporal pole, superior temporal gyrus and left middle temporal gyrus (all P<0.05), and ReHo in AD group decreased in left middle temporal gyrus, right inferior temporal gyrus, left trigonometric frontalis inferior gyrus and left cuneus, while increased in left cerebellum (all P<0.05) compared with in control group. In the analysis based on Chinese brain template Chinese2020, the average of the gray matter volume percentage within the activated areas (ALFF: [38.85±17.88]%, ReHo: [54.69±13.28]%) were higher than those based on traditional standard brain template ICBM152 (ALFF: [33.75±14.70]%, ReHo: [45.66±12.35]%), but without difference (P=0.68, 0.21). Conclusion In rs-fMRI study of Chinese AD, analysis based on Chinese brain template Chinese2020 may provide more accurate information than on conventional westerner brain template.
ABSTRACT
Objective To investigate the value of Chinese brain template Chinese2020 in detecting gray matter (GM) alterations in patients with Parkinson disease (PD) in Chinese population using voxel-based morphometry (VBM). Methods Totally 15 PD patients (PD group)and 15 gender- and age-matched healthy volunteers (control group) were enrolled. Chinese2020 based on Chinese and MNI152 based on Caucasian were used for spatial normalization, respectively. The deformations induced by spatial normalization and gray matter (GM) proportion in the identified brain areas were compared between Chinese2020 and MNI152. The differences of GM volume between PD group and control group were examined using VBM. Results Using MNI152, GM atrophies in PD patients were detected in bilateral temporal lobe extending into ipsilateral insula/parahippocampus/hippocampus, the left superior occipital cortex/cuneus/precuneus, as well as the right putamen. Besides the above mentioned regions, the right middle frontal cortex atrophy was additionally identified using Chinese2020. Particularly, fewer deformations were found when spatially normalizing Chinese population's brain to Chinese2020 than to MNI152. Moreover, GM percentages of detected regions using Chinese2020 were significantly higher than those using MNI152 (t=2.502, P=0.037). Conclusion CBT should be used in neuroimaging studies of Chinese population, which may achieve fewer deformations during spatial normalization, more GM proportions in the identified clusters and improve the accuracy of detection.