ABSTRACT
ObjectiveTo discuss the thought of treatment of orifices in the Chinese herbal classics in the past dynasties based on the correspondence between drugs and symptoms to guide the clinical treatment based on syndrome differentiation. MethodAll the literature data of Chinese herbal classics were retrieved from the database of the Chinese Medical Dictionary， involving 76 works of Chinese herbal classics and covering representative works from the Han dynasty to the Ming and Qing dynasties. The information on Chines herbal drugs for the treatment of orifices was collected and sorted out. According to Chinese Materia Medica （11th Edition） and Pharmacopoeia of the People's Republic of China （2020 Edition）， the nature， flavor， and meridian tropism of the selected Chinese herbal drugs were statistically analyzed. The pathogenesis elements in the treatment of orifices were classified and counted， and the contents of syndrome differentiation and treatment in various Chinese herbal classics were extracted. ResultIn 76 Chinese herbal classics in the past dynasties， 93 Chinese herbal drugs for the treatment of orifices were selected. The nature of drugs was mainly warm， followed by cold and mild. The flavor was mainly pungent， followed by bitter and sweet. In terms of meridian tropism， drugs mainly acted on the lung meridian， followed by stomach， heart， liver， spleen， and kidney meridians. The pathogenesis elements of orifices could be divided into six categories， i.e.， wind invasion， turbid obstruction and Qi stagnation， water and dampness stagnation， blood stasis and collaterals blockage， heat and toxin damage， deficiency of vital Qi and cold coagulation. ConclusionOrifices are mainly treated with drugs effective in dispelling wind and pathogenic factors， resolving turbidity and removing stagnation， inducing diuresis and eliminating dampness， promoting blood circulation and dredging collaterals， clearing heat and purging fire， tonifying deficiency and dispelling cold， which are used in combination. Eliminating pathogenic factors and dredging， tonifying deficiency and purging excess are the main characteristics of treatment of orifices based on syndrome differentiation， which is in line with the physiological dysfunction state of orifices in losing the function， evil Qi blockage and healthy Qi deficiency.
ABSTRACT
Objective: To evaluate the therapeutic efficacy of acupuncture plus Dang Gui Bu Xue Qu Feng Tang for benign essential blepharospasm (BEB). Methods: A prospective randomized controlled trial was performed. A total of 105 participants were randomized 1:1:1 into an acupuncture group, a herbal medicine group and an acupuncture plus herbal medicine group. Participants in the acupuncture group received manual acupuncture treatment, twice a week. Participants in the herbal medicine group received Dang Gui Bu Xue Qu Feng Tang, oral administration, once a day. Participants in the acupuncture plus herbal medicine group received both treatments. The therapeutic effects of the three groups were evaluated after four weeks of treatment. The primary outcome was the Jankovic rating scale (JRS) score, and the secondary outcome was the blepharospasm disability index (BSDI) score. Results: After four weeks of treatment, the JRS total scores significantly decreased in all three groups versus baseline (P<0.05). A greater reduction in the JRS total score was reported in participants in the acupuncture plus herbal medicine group (P<0.05), but there was no significant difference between the acupuncture group and the herbal medicine group (P>0.05). The acupuncture plus herbal medicine group had a greater decrease in the JRS severity score than the herbal medicine group (P<0.05). The reduction in the JRS frequency score was not significantly different among the three groups (P>0.05). The BSDI scores significantly decreased in all three groups versus baseline (P<0.05), but the reduction in the BSDI score was insignificantly different among the three groups (P>0.05). Conclusion: It is effective in the treatment of BEB either to use acupuncture and Dang Gui Bu Xue Qu Feng Tang alone or in combination. The combination therapy shows a more significant effect than either of the treatment alone.
ABSTRACT
Artificial intelligence technology based on pathological slice images promotes the development of medicine, and the development of artificial intelligence technology in pathological imaging benefits from the digital whole slide. The digitization of whole slide can provide a large amount of data that can be freely amplified and conveniently labeled, which is conducive to deep learning and clinical application. Digital whole slide is not only applied to human pathology, but also to animal and plant pathology. In this paper, we systematically discussed the role of digital whole slide combined with artificial intelligence technology in pathological recognition, feature extraction, animal models and plant morphology, aiming to provide new clues for the clinical practice of digital pathology.
ABSTRACT
To mainly analyze the prescription rules of Chinese herbal drugs for radiation induced lung injury, optimize the prescriptions, and provide a reference for the clinical treatment of radiation induced lung injury. The major Chinese databases CNKI, CBM and Wanfang data were searched to obtain the literature on Chinese herbal drugs for radiation induced lung injury. BICOMS 2 software was used to extract and collect all Chinese herbal drugs information and generate the co-occurrence matrix; NetDraw and Gcluto software were then used to make network map and visualization matrix for analysis. A total of 552 articles (19 types and 304 Chinese herbal drugs) were included. Ophiopogon japonicus had the highest frequency (229 times), followed by Astragalus membranaceus(181 times), Glycyrrhiza uralensis (166 times), and Scutellaria baicalensis (150 times). After the classification of efficacy, deficiency-supplementing medicinal (69 kinds of Chinese herbs), heat-clearing medicine (51 kinds of Chinese herbs) and phlegm cough medicine (42 kinds of Chinese herbs) accounted for 53.29% of all the Chinese herbs, acting in the main position. After the prescription analysis for the top 25 herbal prescriptions, six main structures of common prescriptions were found for the treatment of radiation induced lung injury. There are many kinds of Chinese herbal drugs for the treatment of radiation induced lung injury in clinical application. In the future, researchers can mainly focus on Ophiopogon japonicus etc. as the main drugs, combine with other high-frequency Chinese herbal drugs found in this study, or directly refer to the main structures of commonly used prescriptions found in this analysis.
ABSTRACT
Naditional Chinese mediane (TCM) and natural products are widely metabolized inorgamsm. Due to the complexity of their metabolic pathways and multiple components, multiple targets and the overall regulation functions of TCM and natural products in organism, metabonomics have been widely applied in researches on TCM metabolites and pharmacodynamic mechanism However, metabonomics study needs the information of large amount of exgeroms and endogenous metabolites in the biological fluids, which requires more powerful analytical techniques. This paper reviewed liquid chromatography coupled with mass specnomeny (LC-MS) techniques commonly applied in TCM metabolite and metabonomics researches. We summarized and comparatively analyzed the data of 23 literatures we retrieved from Pubmed database. We focused on the advantages and disadvantages of various LC-MS techniques in TCM metaboromics studies; the advantages of UPLC-Q-TOF/MS were introduced in a detained manner, hcping to cast new lights on TCM metabonomics researches.
ABSTRACT
Objective: To develop methods for determining the disintegration time of oral disintegrating tablets (ODTs) of Chinese herbal drug, and to select the evaluation method with good reproducibility, resolving power, and in vivo and in vitro correlation. Methods: Several placebo ODTs and Chinese herbal drug ODTs were prepared. Their in vitro disintegration time was determined by self-developed method and routine methods, and the results were compared with the oral disintegration time. The reproducibility, resolving power, and the correlation between in vivo and in vitro of those methods were evaluated. Results = Different determination methods obtained different disintegration results of the same tablet. Graduated cylinder and improved disintegration apparatus both had shortcomings and their determination results were very different from that of the oral disintegration time. Our self-developed disintegration device could better determine the disintegration ability of the ODTs, and the result was closer to the oral disintegration time, with clear end point of disintegration and better reproducibility, resolving power, and the in vivo and in vitro correlation compared with other methods. Conclusion: Our self-developed device is suitable to determine in vitro disintegration time of ODTs, and may serve as a reference for quality control of ODTs.
ABSTRACT
Objective: To search for effective volatile oil of Chinese crude drug for killing demodex in vitro. Methods: The demodex mites were collected by adhesive cellophane tape technique. The killing effects of different volatile oils against Df and Db were observed by microscope. Normal saline and Xinfu Manling Ointment were used as negative and positive controls, respectively. Skin irritation tests for normal and wounded skin and acute toxicity test were carried out using rabbit skin. Results: The volatile oils of 6 Chinese crude drugs, including clore, orange fruit, manchurian wildginger, cinnamon bark, rhizoma alpinae, and pricklyash peel, were highly potent in killing Df and Db in vitro; and the volatile oil of clore and manchurian wildginger had a better killing effect against Df than Db(P< 0.05). The scores for irritation to normal and wounded rabbit skin were 0.2 and 0.3, respectively, and acute toxicity test showed no obvious toxicity. Conclusion: The volatile oils of the 6 mentioned Chinese crude drugs have satisfactory anti-mite activities in vitro. The volatile oil of clore shows a remarkable activity against demodex in vitro, with good skin safety.
ABSTRACT
Objective To study the clinical the rapeutic efficacy of reformed-fallopian tube recanalization (RFTR) with Chinese traditional medicines for treatment of infertility resulted from fallopian tube obstruction.Methods 80 patients of infertile women with fallopian tube obstruction were randomly divided in to the treated group( n = 40, treated with RFTR combined with Chinese traditional medicines) and the control group( n = 40,treated with RFTR alone). All cases were followed up for 6 to 12 months. The efficacy rate,pregnancy rate,ectopic pregnancy rate and the re-adhension rate were recorded in both groups. Results The efficacy rate of treated group and the control group were 72.5 % and 57.5 % respectively, with statistical significance( P < 0.05 ). The pregnancy rates of the two groups were 52.5 % and 30.0 % respectively. The ectopie pregnancy rate of the two groups were 5 % and 7.5 % respectively. Conclusion RFTR with Chinese traditional medicines therapy is an effective method to treat in fertility resulted from fallopian tube obstruction.
ABSTRACT
PURPOSE AND METHODS In order to investigate the effects of Zhaolian on anti tumor promotion,we studied its influence on liver precancerous lesion in rats induced by DEN.RESULTS (1)Liver function of rats was protected ( P
ABSTRACT
Sheng-hai-long (SHL) is a traditional Chinese medicine consisting of Syngnathus,Hippocampus,Cornu Cervi Pantotrichum,Radix Ginseng,Herba Cistanchis, Radix Angelicae, Fructus Lycii , and ten odd herbal drugs. In an attempt to explore its antifatigue action, the maximal aerobic capability (MC..) and maximal anaerobic capability (MCn) were measured in 40 mid-long distance runners (age 16. 7+1. 9 y;body weight 64+5 kg) before and after 1 month of intensive training. They were randomly divided into two groups; 20 received orally SHL 3 g ?kg"1 daily, while the other 20 did not. The results showed that the MC, in 1 -min all-out test,MC,and maximal lactic acid production from a maximal graded load test were all increased much more in SHL group than those in the control group ( P