ABSTRACT
Chinese materia medica (CMM) formula granule is made from CMM extract powder and suitable pharmaceutical excipients, powder properties of CMM extract powder such as the particle size, hydroscopicity, and fluidity directly affect thepelleting quality of CMM formula granule. Drying is one of the indispensable operating units for preparations of CMM extract, which has great influence on the powder properties of CMM extract powder. Therefore, there is a certain correlation between the drying process and pelleting quality of CMM formula granule. Through the literature research, this paper summarizes the engineering principle and characteristics of each main granulation method, analysis of the evaluation factors of pellet quality, and combines with experimental research to explore the correlation between the drying process of CMM extract and pelleting quality of CMM formula granule in the perspective of powder properties. Finally, we puts forward that more attention should be payed to study the drying process of CMM extract, in order to further improve the quality of pelleting quality of CMM formula granule.
ABSTRACT
The development of Chinese materia medica (CMM) formula granule is a great reform on CMM. Compared with the traditional herbal pieces, CMM formula granule is not only convenient and rapid-acting as boiling-free, but also advanced in producing techniques, and easily handled in both storage and quality-control. It could perfectly meet the basic reqirement on modern drugs and have a broad market prospect both at home and abroad. The popularization and application of CMM formula granule could be a new way to promote the internalization of CMM. Through the analysis of the pushing effects, international competitive advantages, and problems on accessing to the international market, this essay tries to put forward some effective countermeasures for CMM formula granule with expecting to provide a new idea and a new route for the internationalization of CMM.