ABSTRACT
The quality of Chinese materia medica (CMM) has become an important factor affecting the inheritance and development of traditional Chinese medicine. However, due to the complexity of CMM ingredients and the specificity of prescription application, the current quality standards of CMM are difficult to guarantee clinical efficacy. Academician Changxiao Liu proposed the concept of the quality marker (Q-marker) of CMM and its basic attributes, which provided a direction for the study of CMM quality standards. Chinmedomics, integrating serum pharmacochemistry and metabolomics technology, under the conditions of correspondence of prescription-syndrome with therapeutic effect, can be used to find the Q-markers of CMM which are related to the clinical efficacy, and reflect the compatibility of prescriptions, and trace the in vivo metabolism and preparation process. The research strategy based on Chinmedomics is an effective method for discovering the Q-markers of CMM, it has been applied to discovery Q-markers of Yinchenhao Decoction, Liuwei Dihuang Pill, NanShi Capsule, AS1350, and other CMM formula as well as the health products.
ABSTRACT
Chinese materia medica (CMM) health products play an important position in the field of health products at home and abroad because of its long history of health, unique diet theory, and wealth resources of medicinal herbs. To inherit the theory of traditional Chinese medicine (TCM) and develop the health products with TCM characteristics, this paper has summarized the development status and common problems of CMM health products in recent years, and put forward the design idea based on the theory and advantage of TCM for designing the development model of CMM health products more scientifically and reasonably, which has followed the theory of dialectics of eight aspects, five elements, physique theory, and so on. An effort is made to create health products with TCM characteristics and advantages in order to adapt to the health needs of different people, which would make significant contribution to the people's health and industrial development.