ABSTRACT
Alzheimer’s disease (AD) is one of the main pathogenies of the cognitive decline in aging population. Paeoniflorin is a water-soluble monoterpene isolated from the roots of Paeonia lactiflora or P. suffruticosa, which are both in the family Ranunculaceae. Paeoniflorin has the effect of improving the cognitive ability, sedative, anti-inflammatory, analgesic, and spasmolytisch activities. It could also regulate hyperphosphorylation of Tau and Aβ proteins; Paeoniflorin can restore the balance of neurotransmitter and neurotransmitter receptors including acetylcholine, nerve growth factor, calcium ion, α7 nicotinic acetylcholine receptor and adenosine receptors, and reduce inflammation, oxidative stress and neuron apoptosis in AD animal and cell models. This paper reviewed relevant research in the past decade about the effect of paeoniflorin on AD, which may provide theoretical basis to use agent from Chinese medicine for AD prevention and treatment.
ABSTRACT
Hyperlipidemia is a common clinical disease. In recent years, the incidence of hyperlipidemia increased, and patients gradually increased. Hyperlipidemia easily leads to atherosclerosis, coronary heart disease and other cardiovascular and cerebrovascular diseases, and causes crisis to human health. Clinically, Western medicine treatment has a good effect, but also the existence of side effects and even toxic effects, long-term use of drug resistance and other issues. Chinese materia medica (CMM) under the guidance of traditional Chinese medicine theory, with good efficacy and side effects of small features in the clinical dialectical treatment, plays the characteristics of Chinese medicine, and has obvious advantages. In this paper, CMM monomer, single CMM, compound, and integrated traditional Chinese and Western medicine in the treatment of hyperlipidemia were reviewed, and Chinese medicine lipid-lowering development prospects and problems were analyzed.