ABSTRACT
Parkinson's disease （PD） is a progressive chronic neurodegenerative disorder with a complex pathogenesis involving oxidative stress， neuroinflammation， mitochondrial dysfunction， and other factors. Currently， the clinical treatment of PD mainly includes levodopa， dopamine receptor agonists， monoamine oxidase B inhibitors， catechol-O-methyltransferase inhibitors， and anticholinergic drugs， but there is a lack of disease-modif g therapies that can definitively improve disease progression. According to the understanding of traditional Chinese medicine （TCM）， PD is characterized by asthenia in origin and sthenia in superficiality. It is primarily caused by liver-kidney Yin deficiency， Qi-blood insufficiency， and closely related to wind， fire， phlegm， and blood stasis. Numerous clinical practices have shown that TCM has significant clinical value in the prevention and treatment of PD， the management of motor and non-motor symptoms， and the neuroprotection of dopaminergic neurons. The underlying mechanisms of TCM include antioxidative stress， anti-neuroinflammation， and regulation of mitochondrial dysfunction. This article categorized and summarized the pathogenesis of PD， systematically elucidated the pharmacological actions and molecular mechanisms of TCM monomer extracts and compounds in the prevention and treatment of PD， and provided the latest clinical research progress， aiming to provide references for the development and clinical use of TCM for PD.
ABSTRACT
Psoriasis is a common clinical chronic inflammatory skin disease with a complex and diverse etiology and unrevealed pathogenesis. In traditional Chinese medicine （TCM）， psoriasis is caused by internal and external factors. To be specific， external factors such as external wind， cold， dampness， heat， insects， and other pathogenic factors can result in Qi obstruction， blood stasis， and loss of nourishment in the skin， and internal and external factors such as wind， dampness， and toxic qi attacking the exterior， heat and dryness in the blood aspect， difficulty in flourishing due to blood dryness， and blood deficiency in the body， combined with external contraction of wind and dryness trigger the disease. Modern doctors have conducted research from the blood aspect， including blood heat， blood deficiency， blood stasis， and blood dryness. Modern medicine believes that it is related to genetics， immunity， infection， and other factors， and the research on its mechanism focuses on genetic susceptibility， immune system disorder， bacterial infection， and other aspects. At present， various clinical therapies are available， mainly including systematic treatment and local external application of drugs. While treating psoriasis， TCM mainly employs oral administration or external application of Chinese medicine and traditional therapies to regulate the immune system and gene targets and resist oxidation， with high safety and few adverse reactions. At present， although the research on the mechanism of TCM in the treatment of psoriasis has been gradually deepened， there are few detailed summaries on the mechanism of TCM in the prevention and treatment of psoriasis. Based on the research on TCM and western medicine in the treatment of psoriasis， this paper reviewed the mechanism of TCM in the prevention and treatment of psoriasis and proposed a comprehensive clinical and experimental research profile， aiming to provide references for further exploring the pathogenesis， treatment， and corresponding mechanism of psoriasis.
ABSTRACT
To dig out and analyze the drug rule of COVID-19 prevention prescriptions from provinces and cities by using Traditional Chinese Medicine Inheritance Support System, summarize and explore its potential new prescription. The Chinese medicine prevention programs for COVID-19 were collected and searched from the official website of the Health Commission and State Administration Medicine of Traditional Chinese Medicine of the country and provinces, autonomous regions, and municipalities. TCM prevention programs in 17 provinces including Heilongjiang, Beijing, Tianjin, Hebei, Henan, Jiangxi, Sichuan, Hubei, and Hunan, etc were received. A total of 82 herbs were included in 64 prescriptions, the most frequently used Chinese herbs were Astragalus membranaceus, Lonicera japonica, etc. Tonifying deficiency drugs with sweet and warm natures were used the most, the Chinese herbs distributed in the lung channel was the most in channel tropism drugs. Analysis by association rule, eight combinations of commonly used drugs were obtained. Based on entropy clustering method rule analysis, seven potential new prescriptions were obtained. Tonifying deficiency drugs are often used in various places to prevent COVID-19, focusing on the lung, spleen and stomach. Although the specific details are different, they all reflect the preventive thinking of traditional Chinese medicine.
ABSTRACT
This paper analyzed the importance and urgency of clinical research of HIV/AIDS and discussed the present research situation and bottleneck of HIV/AIDS clinical research . The application and advantages of Chinese medicine in the clinical research of HIV/AIDS had been listed . And it summarized the Chinese medicine research results on HIV/AIDS management . It also suggested the outlook of Chinese medicine in the HIV/AIDS clinical research .