Investigation on solubility of two products of chlorpheniramine with release action

Chlopheniramine (chlorphenamine) is a racemic antiallergic antihistaminic H1 drug presenting 2 enantioners. The bioequivalence of two sustained-released formulations of racemic chlopheniramine combined with phenylpropanolamine was assessed firstly, in a dissolution test in vitro according to USP requirements. The present work compares in vitro dissolution rates of two formulations of chlopheniramine maleate. The two formulations are equivalent in vitro, both in a water medium or in a SGF/SIF medium. The pH is not a critical parameter affecting drug release and allows to use purified water for chlopheniramine dissolution test

HYPOTHERMAL EFFECT OF TOTAL GLUCOSIDES OF PAEONY ROOT AND PRELIMINARY STUDY OF ITS MECHANISM / 中国药理学通报

Total glucosides of paeony root ( TGPs ) ( 5 ~40mg/kg, ip ) had a dose-related hypothermal effect in mice and rats, which was related to the environment temperature. But TGPs ( 40mg/kg, ip or iv ) showed no significant hypothermal effect in guinea-pigs or rabbits. TGPs ( 2, 4 mg/kg, icv ) had a potential hypothermal effect in rats. Chlopheniramine had antagonist effect on hypothermal effect of TGPs in mice and rats.