ABSTRACT
OBJECTIVE:To investigate the quality of Diclofenac sodium sustained-release capsules testing in Shandong prov-ince in 2014,to provide the reference for improving the homogeneity and stability of product quality. METHODS:51 batches of Diclofenac sodium sustained-release capsules from 7 manufacturers(A,B,C,D,E,F,G)were tested by statutory inspection test in respects of property,identification,content uniformity,release rate,related substance,content determination,etc. The inspection results were analyzed statistically. The content of chromium in capsule shell and release curve of diclofenac sodium in dissolution mediums with different pH were explored and tested by literature method (compared by similarity factor f2 with sample from A). RESULTS:All items of samples were in line with the quality standard,but there was difference in the quality of samples among different manufacturers,such as the content ranged 92.4%-102.1%. In exploration test,the content of chromium was lower than the limit requirement,but the content of diclofenac sodium had great difference among different manufacturers and different batch-es. Compared with the sample from A manufacture,the f2 from B,C,D,E,F,G manufactures ranged 37-86. CONCLUSIONS:Di-clofenac sodium sustained-release capsules are superior in quality. But it is still suggested to strengthen quality study and control, and raise the standard for release rate test.
ABSTRACT
Chromium (VI) is moderate to severe toxic which is responsible to produce deleterious effects in human beings and animals. The sources of contamination of chromium in natural waters and in the environment are from electroplating, tanning industries and waste solution from oxidative dyeing and leaching from sanitary land – fills. Hence the determination of chromium is of great interest to analytical and environmental chemists. The present study deals with the determination of physico-chemical parameters of electroplating effluents collected from a local industry. Probable reduction of hexa valent chromium was also attempted using standard iron (II) sulphate solution.