A study on pathogenesis and inheritance risk of congenital mental retardation / 重庆医科大学学报

Objective:To investigate the genetic factors relating to mental retardation (MR).Methods:We have analysed 840 cases of congenital mental retardation with biochemistry lab tests,cytogenetic study and family investigation.Results:21 cases were due to monogenic disorders (2.50%);216 cases were due to chromosomal diseases (25.71%);13 cases were due to polygenic disorders (1.55%);590 cases were due to unknown causes (70.24%).Conclusion:It suggested that occurrence of mental retardation is related to both genetic factors and environmental factors.