Serum Vitamin D Status in Iranian Fibromyalgia Patients: according to the Symptom Severity and Illness Invalidation

BACKGROUND: This study was designed to assess serum vitamin D status (25-OHD) in the fibromyalgia (FM) patients and to compare it with a healthy control group. It also aimed to investigate the correlation of serum vitamin D level with FM symptom severity and invalidation experiences. METHODS: A total of 74 consecutive patients with FM and 68 healthy control participants were enrolled. The eligible FM patients completed the Illness Invalidation Inventory (3*I), the Revised Fibromyalgia Impact Questionnaire (FIQR) and a short-form health survey (SF-12). Venous blood samples were drawn from all participants to evaluate serum 25-OHD levels. Mann-Whitney tests and multiple logistic regression analyses were performed and Spearman's correlations were calculated. RESULTS: 88.4% of FM patients had low levels of serum 25-OHD. FM patients had significantly higher level of serum 25-OHD than the control group (17.24 ± 13.50 and 9.91 ± 6.47 respectively, P = 0.0001). There were no significant correlations between serum 25-OHD levels and the clinical measures of disease impact, invalidation dimensions, and health status. Multiple logistic regression analyses revealed that an increased discounting of the disease by the patient's spouse was associated with a 4-fold increased risk for vitamin D deficiency (OR = 4.36; 95% CI, 0.95-19.87, P = 0.05). CONCLUSIONS: This study showed that although high rates of vitamin D insufficiency or deficiency were seen among FM patients and healthy non-FM participants, but it seems there was no intrinsic association between FM and vitamin D deficiency. Addressing of invalidation experience especially by the patient's spouse is important in management of FM.

Estrategias y problemas asociados a la analgesia postoracotomía / Strategies and problems associated with postoperative analgesia after thoracotomy

Introducción: la toracotomía es una de las incisiones quirúrgicas más dolorosas. La exposición quirúrgica de la cavidad torácica causa daño a múltiples estructuras nociceptivas en la pared del tórax y las vísceras cardiopulmonares. Existe una alta incidencia de dolor posoperatorio agudo y crónico que puede retardar la recuperación y causa la invalidez a largo plazo. La prevención y tratamiento del dolor después de la toracotomía es un desafío que puede requerir una variedad de intervenciones y es de vital importancia para minimizar las complicaciones pulmonares. Objetivo: exponer las estrategias para la prevención y tratamiento de este tipo de dolor. Métodos: revisión exhaustiva de la literatura disponible en cuanto a las estrategias basadas en evidencias para la prevención y tratamiento del dolor post-toracotomía. Resultados: el tratamiento subóptimo del dolor después de la toracotomía tiene consecuencias importantes, en especial en los pacientes con limitada reserva pulmonar siendo la más frecuente e importante la disfunción pulmonar. Se exponen los principios generales del tratamiento del dolor post-toracotomía y se abordan las técnicas actuales para su control. Conclusiones: la analgesia epidural torácica es actualmente el estándar para la analgesia tras la cirugía de tórax y en ausencia de contraindicaciones todos los pacientes programados para la cirugía torácica deben tener colocado un catéter epidural torácico preoperatorio.

Background: thoracotomy is one of the most painful surgical incisions. The surgical exposure of the thoracic cavity causes damage to multiple structures in the nociceptive chest wall and cardiopulmonary viscera. There is a high incidence of chronic and acute postoperative pain that can delay the recovery and cause long-term disability. The prevention and treatment of post-thoracotomy pain is a challenge that may require a variety of surgeries and is of vital importance to minimize pulmonary complications. Objective: to show strategies for the prevention and treatment of this type of pain. Methods: a detailed review of the available literature in relation to evidence-based strategies for the prevention and treatment of post-thoracotomy pain was made. Results: the suboptimal treatment of post-thoracotomy pain has important implications, especially in patients with limited pulmonary reserve, being pulmonary dysfunction the most frequent and important one. The general principles for the treatment of post-thoracotomy pain and current techniques to deal with its control are shown. Conclusions: thoracic epidural analgesia is currently the standard analgesia after a thoracic surgery and in the absence of contraindications, all patients scheduled for this type of surgery should have been placed a preoperative thoracic epidural catheter.