ABSTRACT
Objective To assess the correlation of serum uric acid (SUA) and microalbuminuria (MAU) with chronic vascular disease in type 2 diabetes mellitus (T2DM). Methods The study enrolled 892 T2DM patients. The association of different SUA and MAU levels with the incidence of chronic vascular disease was evaluated. Chronic vascular disease included coronary artery disease (CAD),cerebrovascular disease (CVD),diabetic nephropathy (DN),diabetic retinopathy (DR),and diabetic peripheral neuropathy (DPN). Results With increasing levels of SUA and MAU,the incidence of chronic vascular disease increased. In addition,the level of SUA was positively correlated with the incidence of CAD,CVD,DN,DR,DPN,and total chronic vascular disease,while the MAU level was positively associated with the incidence of CAD,CVD,DR,DPN,and total chronic vascular disease. Multivariate logistic regression analysis revealed that SUA level was an independent predictive risk factor for patients with concurrent CAD,CVD,DN,DR,DPN,and total chronic vascular disease,and MAU level independently predicted the risk of CAD and CVD. Conclusion The levels of SUA and MAU may be reliable biomarkers for prediction of the risk of chronic vascular disease in T2DM patients.
ABSTRACT
A nivel mundial, está ocurriendo un proceso de transición epidemiológica con un incremento de la morbilidad y la mortalidad por enfermedades no transmisibles y aunque el fenómeno es global es más acelerado en los países emergentes. Entre estas enfermedades se destacan la enfermedad cardio-vascular, la enfermedad cerebrovascular, la hipertensión arterial, la diabetes mellitus , la macroangiopatía y la enfermedad renal crónica. Estas enfermedades tienen en común que en su origen, progresión a la cronicidad y en sus complicaciones está presente el daño vascular y comparten los mismos factores de riesgo. En este artículo, se analiza la morbilidad, mortalidad y tendencia de estas enfermedades, los principales riesgos y la transición de éstos que están influyendo en este problema de salud epidémico. Se propone un nuevo paradigma integrador de
An epidemiological transition is ocurring throughout the world, leading to an increased morbidity and mortality by non-communicable diseases; in despite of the global characteristic of this phenomenon it is more accelerated in the emerging countries. Cardiovascular disease, cerebrovascular disease, diabetes mellitus, hypertension, macroangiopathy and chronic renal disease are among the main diseases. These diseases have in common that in their origin, progression to chronicity or their complications the vascular damage is presented and on the other hand shares the same risk factors. In this article is analysed the morbidity, mortality and the tendency of these diseases and the risks and transition risks that may influence in this epidemic health problem. A new paradigm integrating the concept of chronic vascular disease and estrategies for its prevention is proposed.