ABSTRACT
The objective of this study was to evaluate the potential of n-butanol extract obtained from flowers of Chrysanthemum fontanesii (Cf) and vitamin E against kidney oxidant injury induced by sodium valproate in mice. The evaluation was made through Histopathological examination and measuring kidney lipid peroxidation (LPO) and antioxidant parameters: reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase. Severe alterations in all biomarkers were observed after injury with VPA. Treatment with Cf extract and vitamin E resulted in markedly decreased levels of LPO while increased levels of GSH and antioxidant enzymes activities were observed. In conclusion, n-butanol extract of Cf may be an interesting candidate for the treatment of kidney injury induced by VPA through enhancing endogenous antioxidant defenses and normalizing the kidney histopathological architecture.
ABSTRACT
The chemical composition of essential oil isolated from Chrysanthemum fontanesii and C. coronarium by hydrodistillation, was analysed by GC and GC/MS. A total 66 compounds representing 97.9% of the oil were identified in C. fontanesii, and 44 components representing 97.2% of the total oil in C. coronarium. The chemical composition of C. fontanesii and C. coronarium, is very different, the only common components are α-pinene, β- pinene, myrcene and Δ3-carene. The Essential oil of C. fontanesii and C. coronarium was tested for antibacterial activity against nine bacteria strains. The oil showed modest effect against Staphylococcus aureus ATCC 25923, and it has no significant antibacterial activity against the other bacteria tested. The population of C. fontanesii studied showed a diploid chromosome number 2n = 2x = 18 and a tetraploid 2n = 4x = 36 for C. coronarium.