ABSTRACT
Objective:To explore the efficacy of ciclopirox olamine vaginal suppositories combined with fluconazole in the treat-ment of vulvovaginal candidasis. Methods:Totally 74 cases of vulvovaginal candidasis( VVC)infection were randomly divided into two groups with 37 ones in each. The control group orally received fluconazole combined with terbinafine hydrochloride vaginal effervescent tablets,and the observation group orally received fluconazole combined with ciclopirox olamine vaginal suppositories. The recent(7 days)and long-term(1 and 3 months)clinical curative effects and the drug safety in the two groups were observed and compared. Re-sults:after the 7-day treatment,the total clinical effective rate of the two groups showed no significant difference(P>0. 05);after the 1-month follow-up,the recurrence rate of the two groups had no significant difference(P>0. 05);after the 3-month follow-up,the re-currence rate of the observation group(2. 7%)was significantly lower than that of the control group(22. 2%,P<0. 05). The two groups showed no serious adverse drug reactions. Conclusion:Fluconazole combined with ciclopirox olamine vaginal suppositories in the treatment of vulvovaginal candidasis exhibits promising curative effect and low recurrence rate without serious adverse reactions.