ABSTRACT
Objective To study the chemical constituents of the fruits of Xylocarpus granatum. Methods The isolation and purification were carried out by silica gel column chromatography, Sephadex, preparative TLC, and preparative HPLC. The structures of the isolated compounds were identified with the help of HR-ESI-MS, 1H-NMR, 13C-NMR, H-H COSY, HMQC and HMBC techniques. Results Seventeen compounds were isolated and elucidated from the fruits of X. granatum, their structures were identified as: grantumin C (1), cipadesin A (2), xylocarpin G (3), febrifugin (4), tigloylseneganolide A (5), khaysin T (6), cipadesin (7), granatumin B (8), xyloccensin S (9), granaxylocarpin C (10), xylogranatin E2 (11), xyloccensin Q (12), xyloccensin P (13), cedrodorin (14), xylorumphiins D (15), hydroxydammarenone-II (16), and bis (2-ethylhexyl) phthalate (17). Conclusion Compounds 2, 7, 14, 16 and 17 are isolated from the plants of Xylocarpus Koenig for the first time. Compound 15 is obtained from X. granatum for the first time.