Circumscribed Palmar Hypokeratosis Showing Bowenoid Change Secondary to Human Papilloma Virus / 대한피부과학회지

Circumscribed palmar or plantar hypokeratosis is a rare condition characterized by the occurrence of an erythematous, well-circumscribed, and depressed macule or patch on the palms or soles. Histopathologically, it is characterized by sharp, stair-like abrupt thinning of the horny layer between the affected and unaffected skin. The pathogenesis of this condition remains unclear. Recently, the human papilloma virus has been implicated as a possible etiological contributor. Circumscribed palmar or plantar hypokeratosis usually shows a benign course. Previous reports have not described malignant changes in these lesions. However, its association with actinic keratosis has been reported in a previous case. We report a case of circumscribed palmar hypokeratosis showing bowenoid epidermal change with expression of the human papilloma virus types 6 and 16 in a patient who was successfully treated with ingenol mebutate gel and cryotherapy.

Circumscr ibed Palmar Hypokeratosis Treated with Cryotherapy / 대한피부과학회지

Circumscribed palmar or plantar hypokeratosis is a rare dermatosis, and it consists of asymptomatic erythematous, well-circumscribed and depressed patch with scaly borders on the palm or sole. It usually affects middle-aged or elderly women. Histopathologically, it has a sharp stair between the normal and involved skin, and a demarcated area with an abrupt decrease in the horny layer thickness. We report herein a case of circumscribed palmar hypokeratosis that was successfully treated with cryotherapy.

Circumscr ibed Palmar Hypokeratosis Treated with Cryotherapy / 대한피부과학회지

Circumscribed palmar or plantar hypokeratosis is a rare dermatosis, and it consists of asymptomatic erythematous, well-circumscribed and depressed patch with scaly borders on the palm or sole. It usually affects middle-aged or elderly women. Histopathologically, it has a sharp stair between the normal and involved skin, and a demarcated area with an abrupt decrease in the horny layer thickness. We report herein a case of circumscribed palmar hypokeratosis that was successfully treated with cryotherapy.

A Case of Circumscribed Palmar Hypokeratosis / 대한피부과학회지

Circumscribed palmar hypokeratosis is a distinctive disorder characterized by circular area of erythematous depressed skin involving the thenar and hypothenar regions of the palm. We present the case of 66-year-old man with circumscribed palmar hypokeratotic lesion. He developed an acquired, solitary, circumscribed, erythematous, depressed skin on the right palm. Histopathologic study demonstrated a depression of the epidermis, with a sharp stair between normal and involved skin. The epidermis covering the depression showed markedly thinner horny layer and slightly diminished granular cell layer when compared with adjacent noninvolved skin. Serial section failed to demonstrate cornoid lamellae. To our knowledge, this distinctive entity has been previously reported in Korea.