ABSTRACT
Objective:To study the effect of priming technique combined with time limit on shortening the onset time of cisatra-curium besilate. Methods:Totally 112 adult patients undergoing selective operation with general anesthesia were randomly divided into group A, B and C. Fentanyl with the dose of 4 μg·kg-1 and propofol with the dose of 2 mg·kg-1 were used in the three groups as the inducing agents. Group A was first with intravenous injection of cisatracurium besilate 20 μg·kg-1 , and 3 minutes later, the in-ducing agents and cisatracurium besilate with the dose of 80 μg·kg-1 were respectively injected. Group B was first with intravenous injection of cisatracurium besilate with the dose of l00 μg·kg-1 , and 1. 5 minutes later, the inducing agents were injected. Group C was respectively injected with the inducing drugs and cisatracurium besilate with the dose of l00 μg·kg-1 . The T1 percentage before the induction, the time of 90% and 100% inhibition of muscle twitching, the rating of trachea cannula and adverse drug reactions in the three groups were observed and compared. Results:There was no significant difference in the excellent rate of trachea cannula a-mong the three groups (P>0. 05). Compared with group A and B, group C showed no T1 suppression before the induction, while group B with T1 of (9. 8 ± 2. 6) was higher than group A with T1 of (3. 2 ± 1. 5) (P<0. 01). The time of 90% and 100% inhibition of muscle twitching in group C was the longest (P<0. 01), and the incidence of adverse drug reactions in group C was also the highest (P<0. 05). Conclusion:The application of priming principle and time limit can effectively shorten the onset time of cisatracurium be-silate with significant effect and high safety.
ABSTRACT
Objective:To determine the clinical pharmacokinetics of cisatracurium besilate,and its effects on hepatic function and renal function in Chinese patients.Methods: Thirty ASA Ⅰ～Ⅲ,patients undergoing elective surgery were enrolled in this study.Anesthesia was induced by a single injection of cisatracurium 0.15mg/kg.The change of heart rate,blood pressure,skin condition and TOF were observed.When T1 reached the maximum block effect,condition of intubation were appraised and recorded.The inhibition and recovery process of adductor pollicis muscle to stimulation of ulnar nerve with TOF pulses was recorded.Times to T4/T1 inhibition and recovery to 25%,75% and 100% were noted.Which were the observing index for muscle relaxation.Hepatic function and renal function were determined after 24 hours.Results: AS the maximum block effect was 100%intubation completed.Grade one was 93.3%(28cases),and grade two was 6.7(% 2cases).No erubescent phenomenon and bronchitis spasm were discovered.After induction of anesthesia,HR and BP decreased significantly(P