Clinical evaluation of lacrimal gland parameters in patients with thyroid-associated ophthalmopathy using orbital magnetic resonance imagining / 国际眼科杂志(Guoji Yanke Zazhi)

AIM: To evaluate the lacrimal gland parameters and their correlation with clinical examination in patients with thyroid-associated ophthalmopathy(TAO)using orbital magnetic resonance imaging(MRI).METHODS: A total of 38 patients(76 eyes)with TAO were selected as case group, and 26 patients(52 eyes)who matched the gender and age with case group and volunteered to accept examination were selected as normal control group. Patients in case group were categorized into active TAO group and inactive TAO group according to the modified clinical activity score(CAS). The exophthalmos was evaluated on T1WI after obtaining the MRI images, the longest lacrimal gland length, width, and the biggest area in axial and coronal images were evaluated on T2WI, and the maximum T2 value and mean T2 value of the lacrimal gland were recorded.RESULTS: There were no significant differences in age, gender and exophthalmos between active TAO and inactive TAO(P>0.05). The area of lacrimal gland was higher in active TAO than that in inactive TAO, and was higher in inactive TAO than that in control group in coronal and axial section(all P<0.01). The length of lacrimal gland in coronal and axial section was higher in the active TAO than that in the inactive TAO and the control group(all P<0.05). The width of lacrimal gland in coronal and axial section was higher in active TAO and inactive TAO than that in the control group(all P<0.05). The maximum T2 value in the active TAO was higher than that in the inactive TAO and control group, and the inactive TAO was higher than that in the control group(all P<0.05). The average T2 value in the active TAO was higher than that in the inactive TAO and control group(all P<0.05). CAS was positively correlated with lacrimal gland area in axial, coronal section and maximum T2 value(all P<0.01).CONCLUSION: The lacrimal gland is significantly enlarged in patients with TAO, especially in active TAO. The lacrimal gland area in axial, coronal section and maximum T2 value could be potentially utilized as valuable radiographic biomarkers for the activity of TAO.

Integrating magnetization transfer imaging and fat suppression T 2WI for predicting the clinical activity of Graves ophthalmopathy / 中华放射学杂志

Objective:To investigate the value of magnetization transfer imaging (MTI) and fat suppression T 2WI (FS-T 2WI) in predicting the clinical activity of Graves ophthalmopathy (GO). Methods:From October 2020 to July 2021, 64 GO patients were prospectively enrolled in the First Affiliated Hospital of Nanjing Medical University. According to the clinical activity score (CAS), the patients were divided into active group (CAS≥3, 39 patients and 78 eyes) and inactive group (CAS<3, 25 patients and 50 eyes). The coronal MTI and FS-T 2WI were scanned for pre-treatment assessment. Magnetization transfer ratio (MTR) of extraocular muscles, and signal intensity ratio (SIR) between extraocular muscles and temporalis were measured, respectively. The independent-sample t-test was used to compare the MTR and SIR between two groups. The correlations between MRI parameters and CAS were analyzed using Spearman correlation analysis. The receiver operating characteristic (ROC) curve was performed to evaluate the value of each and combined parameters for predicting the clinical activity of GO. The DeLong test was used to compare the area under the curve (AUC). Results:The MTR of active group and inactive group were 0.45±0.04 and 0.51±0.04, respectively, the difference was statistically significant ( t=7.62, P<0.001). The SIR were 3.4±0.6 and 2.6±0.5, respectively, and the difference was also statistically significant ( t=-8.20, P<0.001). MTR was negatively correlated with CAS ( r=-0.46, P<0.001), while SIR was positively correlated with CAS ( r=0.63, P<0.001). The AUC of MTR, SIR and the combination of MTR and SIR for predicting the clinical activity of GO were 0.840, 0.845 and 0.905, respectively. The combination of MTR and SIR showed higher performance than MTR or SIR alone, and the differences were statistically significant ( Z=2.61, P=0.009; Z=2.15, P=0.032). Conclusions:The quantitative parameters of MTI and FS-T 2WI, namely MTR and SIR, can be used to evaluate the clinical activity of GO. Integrating MTI and FS-T 2WI can improve the diagnostic efficiency.

Anticuerpos contra el citoplasma del neutrófilo y actividad clínica en pacientes cubanos con artritis reumatoide / Antineutrophil cytoplasmic autoantibodies and clinical activity in Cuban patients with rheumatoid arthritis

Introducción: Los anticuerpos contra el citoplasma del neutrófilo se detectan normalmente en pacientes con vasculitis. Aunque estos anticuerpos pueden estar presentes en un amplio número de enfermedades asociadas a estados inflamatorios y autoinmunes, como la artritis reumatoide, no se ha demostrado su significado clínico. Objetivo: evaluar la utilidad de diferentes especificidades antigénicas de los anticuerpos contra el citoplasma del neutrófilo para medir la actividad clínica en pacientes cubanos con artritis reumatoide. Material y Métodos: Se realizó un estudio transversal con 77 pacientes cubanos con artritis reumatoide. Se determinaron la velocidad de sedimentación globular, la proteína C reactiva, el indicador clínico de actividad de la enfermedad, los anticuerpos anti-proteínas citrulinadas, el factor reumatoide y los anticuerpos contra el citoplasma del neutrófilo frente a diferentes especificidades antigénicas. Resultados: La mayor cantidad de pacientes con actividad clínica elevada (> 5,1) pertenecieron al grupo de pacientes positivos de anticuerpos contra el citoplasma del neutrófilo (p=0,0364). Los pacientes con anticuerpos anti-lactoferrina tuvieron mayores valores de actividad clínica (p=0,0304). Mediante análisis multivariado se demostró la influencia de la positividad de anticuerpos anti-lisozima (p=0,0391), de la positividad doble de los anticuerpos anti-proteínas citrulinadas y anti-lactoferrina (p=0,0282), así como de la doble positividad de los anticuerpos anti-proteínas citrulinadas y anti-elastina (p=0,0182) en la actividad clínica. Conclusión: La presencia de anticuerpos contra el citoplasma del neutrófilo que reconocen las especificidades antigénicas lisozima, lactoferrina y elastina se relacionan con mayor actividad clínica en pacientes con artritis reumatoide(AU)

Introduction: Antibodies against neutrophil cytoplasm are normally detected in patients with vasculitis. Although these antibodies can be present in a wide number of diseases associated with inflammatory and autoimmune conditions such as rheumatoid arthritis, their clinical significance has not been demonstrated. Objective: To evaluate the usefulness of different antigenic specificities of antibodies against neutrophil cytoplasm to measure the clinical activity in Cuban patients with rheumatoid arthritis. Material and Methods: A cross-sectional study was conducted on 77 Cuban patients with rheumatoid arthritis. Erythrocyte sedimentation rate, C-reactive protein, the clinical indicator of disease activity, anti-citrullinated protein antibodies, rheumatoid factor, and antibodies against neutrophil cytoplasm against different specificities were determined. Results: The largest number of patients with elevated disease activity (> 5.1) belonged to the group of antibodies against neutrophil cytoplasm positive patients (p=0.0364). Patients with anti-lactoferrin antibodies had higher disease activity values ​​(p=0.0304). Through multivariate analysis, the influence of positive anti-lysozyme antibodies (p=0.0391), of double positivity of anti-citrullinated protein and anti-lactoferrin antibodies (p=0.0282), as well as that of double positivity of anti-citrullinated protein and anti-elastin antibodies (p=0.0182) on disease activity were demonstrated. Conclusion: The antibodies against neutrophil cytoplasm that recognize the antigenic specificities of lysozyme, lactoferrin and elastin are related to higher clinical activity in patients with rheumatoid arthritis(AU)

Imaging application of thyroid associated ophthalmopathy / 国际眼科杂志(Guoji Yanke Zazhi)

@#Thyroid associated ophthalmopathy(TAO)is an autoimmune orbital inflammatory disease. Imaging methods play an important role in evaluating the change of orbital structures and differential diagnosis of orbital disease. In addition, imaging studies can also contribute to analyze the activity and severity of TAO and estimate compressive optic neuropathy(CON).

Correlation between endoscopic scores and clinical activity and histological scores of ulcerative colitis / 中华消化内镜杂志

Objective:To study the intestinal mucosal state of ulcerative colitis (UC) through UC endoscopic scores and to investigate the correlation between the endoscopic scores and clinical activity and histological scores.Methods:A retrospective analysis was performed on data of 152 patients who underwent colonoscopy or sigmoidoscopy in Nanjing Drum Tower Hospital from January 2014 to September 2019. The results were graded with 7 endoscopic scores, namely, Mayo endoscopic score(MES), modified Baron score(MBS), endoscopic activity index(EAI) , Sutherland index(DAI or UCDAI) , Rachmilewitz endoscopic index(REI), Lemann endoscopic index (LEI), and ulcerative colitis endoscopic index of severity(UCEIS). Spearman correlation coefficients between endoscopic score and partial Mayo scores, Truelove-Witts disease severity score and Nancy index (NI), Robarts index (RHI) and Geboes score (GS) were calculated respectively. Consistency of each endoscopic score among different observers was analyzed.Results:Except for the weak correlation between DAI and Truelove - Witts classification ( r= 0.469, P < 0.001), all other endoscopic scores were moderately positively correlated with clinical activity scores with significance( all P<0.001). However, the correlation between 7 endoscopic scores and histological scores was weak ( P<0.001). Except that the consistency of MBS among observers was medium, those of MES, DAI and LEI among observers were poor, and those of UCEIS, EAI and REI among observers were worse ( P<0.001). Conclusion:Endoscopic scores were moderately correlated with clinical activity indexes and weakly correlated with histological scores. However, patients with endoscopic remission may have histologic inflammatory activity, so attention should be paid to histological mucosal healing after endoscopic remission. The consistency of all 7 endoscopic scoring stystems among observers was low, and the repeatability was poor.

Relación entre el estado nutricional y la actividad clínica en pacientes con artritis reumatoide / Relationship between nutritional status and clinical activity in patients with rheumatoid arthritis

Introducción: La artritis reumatoide es una enfermedad autoinmune, inflamatoria, sistémica y crónica que se caracteriza por la afectación de pequeñas articulaciones y causa distintos grados de discapacidad funcional y disminución de la percepción de la calidad de vida relacionada con la salud. Objetivo: Determinar la relación existente entre el estado nutricional y la actividad clínica en pacientes con diagnóstico de artritis reumatoide. Métodos: Estudio descriptivo y correlacional de 96 pacientes con diagnóstico de artritis reumatoide, según los criterios del American College of Rheumatology, quienes fueron atendidos en el Hospital Andino de Chimborazo. Se determinó el estado nutricional mediante el índice de masa corporal y la actividad clínica mediante el sistema Disease Activity Score-28 (DAS 28). Se utilizó la prueba de correlación de Pearson para hallar la relación existente entre el estado nutricional y la actividad clínica. Resultados: El promedio de edad fue de 64,23 años; predominaron los pacientes de 60 años o más (51,04 por ciento) y del sexo femenino (78,12 por ciento). El 67,71 por ciento de los casos presentaban comorbilidades asociadas, específicamente hipertensión arterial (43,07 por ciento), hipotiroidismo (35,38 por ciento) y fibromialgia (32,31 por ciento). El 37,50 por ciento tenía sobrepeso y el 16,67 por ciento, obesidad; el 46,88 por ciento de los pacientes presentó actividad clínica ligera y el 29,17 por ciento moderada. El 14,58 por ciento se encontraba en remisión. Conclusiones: Existe una relación positiva considerable entre el estado nutricional y la actividad clínica de la artritis reumatoide en la población estudiada, conclusión que se basa en el resultado del coeficiente de correlación de Pearson(AU)

Introduction: rheumatoid arthritis is an autoimmune, inflammatory, systemic and chronic disease that is characterized by the involvement of small joints of the hands and feet generating different degrees of functional disability and decreased perception of health-related quality of life. Objective: to determine the relationship between nutritional status and clinical activity in patients diagnosed with rheumatoid arthritis. Methods: descriptive and correlational study in 96 patients diagnosed with rheumatoid arthritis according to the criteria of the American College of Rheumatology who were treated at the Andean Hospital of Chimborazo. Nutritional status was determined by body mass index and clinical activity by DAS 28. Pearson's correlation test was used to determine the relationship between nutritional status and clinical activity. Results: average age of 64.23 years, patients between 60 years or older (51.04 percent) and female (78.12 percent) predominated. 67.71 percent of the cases presented comorbidities associated with a predominance of arterial hypertension (43.07 percent), hypothyroidism (35.38 percent) and fibromyalgia (32.31 percent). Overweight was present in 37.50 percent and obesity in 16.67 percent of cases; 46.88 percent of the patients presented mild clinical activity and 29.17 percent moderate, 14.58 percent were in remission. Conclusions: the presence of nutritional alterations due to excess (overweight and obesity) positively influence the clinical activity of patients with rheumatoid arthritis, finding a significant positive correlation between them(AU)

Meta-analysis of the efficacy of Rituximab in thyroid associated ophthalmopathy / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM: To evaluate the efficacy of rituximab in thyroid associated ophthalmopathy by using a Meta-analysis of the literature. <p>METHODS: Databases such as CNKI, Wanfang, Weipu, China Biomedical, PubMed, Web of Science, OVID, Cochrane Library, and ClinicalTrial.gov were searched. From the establishment of the database to December 31, 2019 on rituximab clinical studies on the treatment of thyroid associated ophthalmopathy. The clinical activity score of thyroid associated ophthalmopathy before and after treatment was used as the main judgment index of curative effect. The retrieved clinical studies were analyzed using RevMan 5.3 statistical software. <p>RESULTS: Six studies were included, two were randomized controlled trials, and four were cohort studies. Meta analysis showed that the application of rituximab in the treatment of moderate to severe thyroid associated ophthalmopathy can significantly reduce the clinical activity score of patients, and has statistical significance \〖<i>SMD</i>=-5.04, 95% <i>CI</i>(-7.08 to -3.01), <i>P</i><0.00001\〗. <p>CONCLUSION: Rituximab can significantly reduce the clinical activity score of patients with moderate to severe thyroid associated ophthalmopathy, and has a good effect on disease control.

Clinical activity of abiraterone plus prednisone in docetaxel-naïve and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer / 亚洲男科学杂志(英文版)

This study investigated the clinical activity of abiraterone plus prednisone in docetaxel-naïve and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer (mCRPC). A total of 146 patients with docetaxel-naïve group (103 cases) and docetaxel-resistant group (43 cases) were enrolled from the Shanghai Cancer Center (Shanghai, China) in this retrospective cohort study. The efficacy endpoints were prostate-specific antigen response rate, prostate-specific antigen progression-free survival, clinical/radiographic progression-free survival, and overall survival in response to abiraterone plus prednisone. Significantly higher prostate-specific antigen response rate was found in docetaxel-naïve group (54.4%, 56/103) compared to docetaxel-resistant group (34.9%, 15/43) (P = 0.047). In addition, significantly higher median prostate-specific antigen progression-free survival (14.0 vs 7.7 months, P = 0.005), clinical or radiographic progression-free survival (17.0 vs 12.5 months, P = 0.003), and overall survival (27.0 vs 18.0 months, P = 0.016) were found in docetaxel-naïve group compared to docetaxel-resistant group, respectively. The univariate and multivariate analyses indicated that lower albumin and visceral metastases were independent significant predictors for shorter overall survival. To sum up, our data suggested that abiraterone plus prednisone was efficient in both docetaxel-naïve and docetaxel-resistant Chinese patients. Moreover, higher PSA response rate and longer overall survival were observed in the docetaxel-naïve group, which suggested that abiraterone was more effective for docetaxel- naïve patients than for docetaxel failures.

Clinical activity of abiraterone plus prednisone in docetaxel-naοve and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer / 亚洲男科学杂志(英文版)

This study investigated the clinical activity of abiraterone plus prednisone in docetaxel-naïve and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer (mCRPC). A total of 146 patients with docetaxel-naïve group (103 cases) and docetaxel-resistant group (43 cases) were enrolled from the Shanghai Cancer Center (Shanghai, China) in this retrospective cohort study. The efficacy endpoints were prostate-specific antigen response rate, prostate-specific antigen progression-free survival, clinical/radiographic progression-free survival, and overall survival in response to abiraterone plus prednisone. Significantly higher prostate-specific antigen response rate was found in docetaxel-naïve group (54.4%, 56/103) compared to docetaxel-resistant group (34.9%, 15/43) (P = 0.047). In addition, significantly higher median prostate-specific antigen progression-free survival (14.0 vs 7.7 months, P = 0.005), clinical or radiographic progression-free survival (17.0 vs 12.5 months, P = 0.003), and overall survival (27.0 vs 18.0 months, P = 0.016) were found in docetaxel-naïve group compared to docetaxel-resistant group, respectively. The univariate and multivariate analyses indicated that lower albumin and visceral metastases were independent significant predictors for shorter overall survival. To sum up, our data suggested that abiraterone plus prednisone was efficient in both docetaxel-naïve and docetaxel-resistant Chinese patients. Moreover, higher PSA response rate and longer overall survival were observed in the docetaxel-naïve group, which suggested that abiraterone was more effective for docetaxel- naïve patients than for docetaxel failures.

Atividade de trabalho e relações de poder: uma intervenção organizacional numa empresa do ramo da aviação / Work activity and power relations: an organizational intervention in aviation company / La actividad laboral y las relaciones de poder: una intervención organizacional en una compañía del sector de la aviación

Este estudo discute uma intervenção organizacional em uma empresa terceirizada do ramo da aviação civil, tendo como base algumas vertentes das chamadas clínicas do trabalho, especialmente a clínica da atividade e a psicossociologia do trabalho. Na ótica da pesquisa qualitativa, utilizaramse de procedimentos como observação da situação de trabalho, entrevistas individuais e grupos de discussão, visando inicialmente a um diagnóstico dos problemas da organização. Em seguida, criou-se um dispositivo de participação dos trabalhadores, por meio de um recurso gerencial denominado desenvolvimento de habilidades humanas (DHH), destinado a reorganizar os processos de trabalho da empresa. A questão dos mecanismos internos de poder é também abordada neste estudo, bem como o alcance do poder de agir dos trabalhadores. Entende-se que este estudo possa contribuir para novas alternativas de inserção do psicólogo nas organizações do trabalho

This study discusses an organizational intervention in an outsourcing company of the civil aviation branch, based in the current called clinical work, specifically the Clinics of Activity and the Psychosociology of Work. From the perspective of qualitative research, it was developed using procedures such as field observations, interviews and discussion groups, aiming initially a diagnosis of the organization's problems. Thereafter, it was created a worker's participation device, through a resource management called Development of Human Abilities (DHH), which intended to reorganize the company's work processes. The issue of internal mechanisms of power is also addressed in this study, as well as the possibilities of worker's acting power. It is understood that this study may contribute to new psychologist insertion alternatives in labor organizations.

Este estudio discute una intervención organizacional de una empresa subcontratista en el sector de la aviación civil, teniendo como base algunas vertientes de las llamadas clínicas de trabajo, en especial la Clínica de la Actividad y la Psicosociología del Trabajo. Desde la óptica de la investigación cualitativa, se usaron procedimientos como la observación de la situación de trabajo, entrevistas individuales y grupos de discusión, buscando inicialmente un diagnóstico de los problemas de la organización. Se creó también un dispositivo de participación de los trabajadores, con una herramienta de gestión denominada desarrollo de habilidades humanas (DHH), destinada a reorganizar los procesos de trabajo de la empresa. La cuestión de los mecanismos internos del poder también se abordan en este estudio, así como el alcance del poder de obrar de los trabajadores. Este estudio puede contribuir a nuevas alternativas de inserción del psicólogo en las organizaciones laborales

Clinical Features of Dry Eye in Thyroid-Associated Ophthalmopathy According to Disease Activity

PURPOSE: To evaluate the clinical features of dry eye in thyroid-associated ophthalmopathy (TAO) according to disease activity and analyze the related factors. METHODS: This study included 157 patients diagnosed with TAO and dry eye between March 2009 and March 2015. According to the clinical activity score (CAS), TAO patients were divided into inactive (CAS < 3) and active (CAS ≥ 3) groups. Clinical features included age, sex, visual acuity, proptosis, palpebral fissure width, orbital computed tomography (CT) findings, thyroid hormones, and ocular surface parameters including tear film break-up time (TFBUT), Schirmer tests, keratoepitheliopathy scores, and ocular surface disease index (OSDI) were obtained and compared between the groups. In addition, correlations between clinical features and ocular surface parameters were analyzed in both groups. RESULTS: In the inactive and active TAO groups, CAS was 1.24 ± 0.69 and 4.23 ± 1.13, respectively (p = 0.001). Thyrotropin-binding inhibitory immunoglobulin was significantly higher in the active TAO group than in the inactive TAO group (p = 0.048). On orbital CT, extraocular muscle hypertrophy was more common in the active TAO group than the inactive TAO group (p = 0.020). No significant difference was found in age, sex, visual acuity, free T4, and thyroid-stimulating hormone between the two groups. During analysis of the tear film and ocular surface parameters, TFBUT (p = 0.006) was shorter and OSDI score (p = 0.028) was higher in the active TAO group than the inactive TAO group. TFBUT was negatively correlated with proptosis (r = -0.432, p = 0.001; r = -0.308, p = 0.032) and palpebral fissure width (r = -0.367 p = 0.012; r = -0.312, p = 0.031) in both groups. OSDI was positively correlated with proptosis in the active TAO group (r = 0.301, p = 0.033). CONCLUSIONS: TFBUT was shorter and OSDI score higher in dry eye patients with active TAO than in patients with inactive TAO. The TFBUT was negatively correlated with proptosis and palpebral fissure width in both groups.

Clinical Features of Dry Eye in Thyroid-Associated Ophthalmopathy According to Disease Activity

PURPOSE: To evaluate the clinical features of dry eye in thyroid-associated ophthalmopathy (TAO) according to disease activity and analyze the related factors. METHODS: This study included 157 patients diagnosed with TAO and dry eye between March 2009 and March 2015. According to the clinical activity score (CAS), TAO patients were divided into inactive (CAS < 3) and active (CAS ≥ 3) groups. Clinical features included age, sex, visual acuity, proptosis, palpebral fissure width, orbital computed tomography (CT) findings, thyroid hormones, and ocular surface parameters including tear film break-up time (TFBUT), Schirmer tests, keratoepitheliopathy scores, and ocular surface disease index (OSDI) were obtained and compared between the groups. In addition, correlations between clinical features and ocular surface parameters were analyzed in both groups. RESULTS: In the inactive and active TAO groups, CAS was 1.24 ± 0.69 and 4.23 ± 1.13, respectively (p = 0.001). Thyrotropin-binding inhibitory immunoglobulin was significantly higher in the active TAO group than in the inactive TAO group (p = 0.048). On orbital CT, extraocular muscle hypertrophy was more common in the active TAO group than the inactive TAO group (p = 0.020). No significant difference was found in age, sex, visual acuity, free T4, and thyroid-stimulating hormone between the two groups. During analysis of the tear film and ocular surface parameters, TFBUT (p = 0.006) was shorter and OSDI score (p = 0.028) was higher in the active TAO group than the inactive TAO group. TFBUT was negatively correlated with proptosis (r = -0.432, p = 0.001; r = -0.308, p = 0.032) and palpebral fissure width (r = -0.367 p = 0.012; r = -0.312, p = 0.031) in both groups. OSDI was positively correlated with proptosis in the active TAO group (r = 0.301, p = 0.033). CONCLUSIONS: TFBUT was shorter and OSDI score higher in dry eye patients with active TAO than in patients with inactive TAO. The TFBUT was negatively correlated with proptosis and palpebral fissure width in both groups.

A associação fibromialgia e lúpus eritematoso sistêmico altera a apresentação e a gravidade de ambas as doenças? / The association of fibromyalgia and systemic lupus erythematosus change the presentation and severity of both diseases?

Introdução A associação da fibromialgia (FM) e de lúpus eritematoso sistêmico (LES) tem sido investigada com resultados conflitantes em relação ao impacto de uma condição na outra. Objetivos Determinar a frequência de FM em uma amostra de pacientes com LES atendidos no Conjunto Hospitalar de Sorocaba (CHS) e o impacto da FM na atividade do LES e na qualidade de vida, bem como do LES na FM. Material e métodos Estudo descritivo e transversal. Incluíram-se pacientes que preenchem os critérios de classificação para LES e/ou de FM do Colégio Americano de Reumatologia (ACR). A amostra total foi dividida em três grupos: FM/LES (pacientes com associação LES e FM), LES (somente pacientes com LES) e FM (somente pacientes com FM). As seguintes variáveis foram Questionário de Impacto da Fibromialgia (FIQ), Índice de Atividade do Lúpus Eritematoso Sistêmico (Sledai), Índices dos Critérios Diagnósticos de Fibromialgia de 2010 (IGS E IDG) e o SF-36. Resultados A prevalência de pacientes com FM entre os pacientes com LES foi de 12%. O FIQ não apontou diferença entre os grupos e indicou que o LES não interferiu no impacto causado pela FM isoladamente. A presença da FM em pacientes com LES não influenciou a atividade clínica dessa doença. Observou-se um forte impacto da FM na qualidade de vida nos pacientes com LES e não foi observado o contrário. Conclusões A prevalência de FM observada nos pacientes com LES é de 12%. A presença de FM afeta adversamente a qualidade de vida dos pacientes com LES. .

Introduction The association of fibromyalgia (FM) and systemic lupus erythematosus (SLE) has been investigated, with conflicting results regarding the impact of a condition on the other. Objectives To determine the frequency of FM in a sample of patients with SLE treated at the Hospital Complex of Sorocaba (CHS) and the impact of FM in SLE activity and quality of life, as well as of SLE in FM. Materials and Methods Descriptive and correlational study. Patients who met the American College of Rheumatology (ACR) criteria for SLE and/or FM were included. The total sample was divided into three groups: FM/SLE (patients with association of SLE and FM), SLE (SLE patients only) and FM (FM patients only). The following variables were used: Fibromyalgia Impact Questionnaire (FIQ), activity index of SLE (SLEDAI), Indices of Diagnostic Criteria for Fibromyalgia 2010 (SSI end GPI) and SF-36. Results The prevalence of patients with FM among SLE patients was 12%. FIQ showed no difference between groups, indicating that SLE did not affect the impact caused by FM alone. The presence of FM in SLE patients did not influence the clinical activity of this disease. A strong impact of FM on the quality of life in patients with SLE was observed; the opposite was not observed. Conclusions The prevalence of FM observed in SLE patients is 12%. The presence of FM adversely affects the quality of life of patients with SLE. .

Psicologia e trabalho docente: intercessões com a clínica da atividade / Psychology and work of teaching: intercessions with clinical activity / Psicología y trabajo docente: intercesiones con la clinica de la actividad

O artigo apresenta uma experiência de pesquisa em uma escola de ensino fundamental na Grande Vitória/ES, que utilizou como dispositivo metodológico a autoconfrontação cruzada com fotos e vídeos a partir da proposta da Clínica da atividade formulada por Yves Clot e seus colaboradores. Considera que no campo específico dos estudos dos processos de trabalho, é preciso retomar o problema da atividade, definida como experiência do labor. Nesse sentido, toma a "Clínica da atividade" como uma aposta, o que se expressa no princípio segundo o qual só é possível analisar o trabalho considerando o modo singular como o trabalhador atualiza a atividade em uma experiência. Desenvolve, nessa direção de análise, um paralelo entre a Clínica da atividade proposta por Yves Clot e colaboradores e o que denomina de experiência do labor.

El artículo presenta una experiencia de investigación en una escuela primaria en Gran Vitória / ES, que utiliza como recurso metodológico transversal selfconfrontation con fotos y videos de la actividad propuesta por la Clínica de la Actividad formulado por Yves Clot y sus colaboradores. Considera que en el campo de estudio de los procesos de trabajo, tenemos que volver al problema de la actividad, que se define como la experiencia de trabajo. En este sentido, toma la "Clínica de la Actividad" como una apuesta, que se expresa en principio de que sólo es posible analizar la obra teniendo en cuenta la forma natural como el trabajador actualiza la actividad en un experimento. Desarrolla en esta dirección de análisis, un paralelismo entre la clinica de la actividad propuesto por Yves Clot y los colaboradores y que él llama la experiencia del trabajo.

The article presents a research experience in an elementary school in Vitória/ES, which used as a methodological device selfconfrontation crossed with photos and videos from the proposal formulated by a Clinical Activity Yves Clot and his collaborators. Considers that in the specific field of studies of work processes, we must resume the problem of activity, defined as work experience. Take the "Activity Clinic" as a bet to that effect, which is expressed in principle, whereby you can only analyze the work considering the unique way as the worker updates the activity into an experience. Develops, this direction of analysis, a parallel between the clinical activity proposed by Yves Clot and employees and styling experience of labor.

Imagine que eu sou seu sósia: Aspectos técnicos de um método em clínica da atividade / Imagine I'm your double: Technical aspects of a method in clinical activity

Este artigo pretende contribuir para uma elucidação sobre alguns aspectos técnicos do método de instrução ao sósia dentro da metodologia da clínica da atividade, que busca ampliar o poder de agir dos trabalhadores. Apesar da vasta literatura sobre o tema, consideramos que há uma lacuna no que diz respeito a uma orientação mais específica sobre "como" realizar uma instrução ao sósia dentro dessa abordagem. Apresentaremos alguns elementos da aplicação da técnica que podem apoiar os profissionais que utilizam a clínica da atividade como um caminho promissor para transformar as situações degradadas de trabalho e preservar a saúde dos trabalhadores. Assim, visamos contribuir para a ampliação e a discussão dos contextos de intervenção...

This article aims at contributing for the elucidation of some technical aspects of the method of instruction to a double under the methodology of clinical activity, which seeks to expand the worker's force. Despite the wide bibliography on the theme, we think that there is a lack of more specific guidance on "how to" conduct an instruction to a double through this approach. We will present some elements of this technique that can stimulate professionals who use the clinical activity as a promising path for changing degraded work situations and preserving the health of workers. This way, we aim to contribute to the expansion and to the discussion on intervention contexts...

Application of MRI in severity grading and activity staging in thyroid associated ophthalmopathy / 中华内分泌代谢杂志

The influence of MRI on severity grading and activity staging in thyroid associated ophthalmopathy (TAO) was evaluated.The results showed that MRI had a higher detection rate in abnormal extraocular muscle than NOSPECS scores(χ~2 = 19.37,P = 0.000).MRI had higher sensitivity,specificity,and accuracy in detection of active TAO than clinical activity score (100% vs 95.7%,88.2% vs 35.3%,96.9% vs 79.7%,respectively).Therefore,MRI improves early detection of atypical grade 4 cases.Signal intensity elevation in adipose suppressed T2WI is helpful to define active stage.