ABSTRACT
Objective To investigate the clinical efficacy and safety of mesalazine combined with Clostridium butyricum tablets in the treatment of colitis gravis.Methods From January 2016 to December 2016, a total of 120 patients with colitis gravis in the Second Hospital of Qinhuangdao were selected in the research .According to different treatment methods,the patients were divided into observation group and control group ,with 60 cases in each group.The control group was given mesalazine , and the observation group was given mesalazine combined with Clostridium butyricum tablets.All the patients were treated for 2 months.The changes of cytokine levels and C -reactive protein were observed.The therapeutic effects and adverse drug reactions were compared between the two groups . Results The total effective rate of the observation group was significantly higher than that in the control group (91.66%vs.78.33%),and there was statistically significant difference between the two groups ( χ2＝4.183,P＝0.041).The level of IL-10 in the observation group was significantly higher than that in the control group [(110.05 ± 2.61)pg/L vs.(98.35 ±2.42)pg/L,t＝25.462,P＜0.05].The IL-18 level in the observation group was significantly lower than that in the control group [(97.74 ±2.82) pg/L vs.(120.86 ±3.21) pg/L,t＝41.914,P＜0.05].The level of C-reactive protein in the observation group was lower than that in the control group [(8.02 ±1.97) mg/L vs.(6.33 ±3.82)mg/L,t＝14.976,P＜0.05].The incidence rate of adverse reactions of the observation group was significantly lower than that of the control group ( 5.00% vs.25.00%, χ2＝9.412, P ＝0.002 ).Conclusion Mesalazine combined with Clostridium butyricum tablets in the treatment of colitis gravis has obvious curative effect , and can effectively improve the levels of cytokines and C -reactive protein and with high safety.
ABSTRACT
Objective To investigate the nursing effect of Clostridium Butyricum tablets combined with phototherapy in the treatment of neonatal jaundice. Methods 60 cases of jaundice from March 2015 to July 2017 were randomly divided into the control group and the observation group, 30 cases for each group. Two groups were treated with Clostridium Butyricum tablets combined with phototherapy treatment, on the basis, the control group was given routine nursing intervention, the observation group was given symptomatic care, efficacy of treatment in the two groups were compared. Results The total effective rate of the observation group was 93.33% (28/30), the control group was 66.67% (20/30), the difference was statistically significant (P<0.05); the total bilirubin levels in the two groups before and after intervention were significantly improved, and the observation group improved the effect obviously better than that of control group (P<0.05). Conclusion The combination treatment of phototherapy plus Clostridium Butyricum tablets for neonatal jaundice has exact efficacy, perioperative therapeutic intervention could effectively consolidate and improve the therapeutic effect, the symptom of children in time and the treatment safety, and it has clinical practical value.
ABSTRACT
Objective To investigate the nursing effect of Clostridium Butyricum tablets combined with phototherapy in the treatment of neonatal jaundice. Methods 60 cases of jaundice from March 2015 to July 2017 were randomly divided into the control group and the observation group, 30 cases for each group. Two groups were treated with Clostridium Butyricum tablets combined with phototherapy treatment, on the basis, the control group was given routine nursing intervention, the observation group was given symptomatic care, efficacy of treatment in the two groups were compared. Results The total effective rate of the observation group was 93.33% (28/30), the control group was 66.67% (20/30), the difference was statistically significant (P<0.05); the total bilirubin levels in the two groups before and after intervention were significantly improved, and the observation group improved the effect obviously better than that of control group (P<0.05). Conclusion The combination treatment of phototherapy plus Clostridium Butyricum tablets for neonatal jaundice has exact efficacy, perioperative therapeutic intervention could effectively consolidate and improve the therapeutic effect, the symptom of children in time and the treatment safety, and it has clinical practical value.