The characteristics and correlations of vaginal flora in women with cervical lesions / 中华肿瘤杂志

Objective: To explore the characteristics and correlations of vaginal flora in women with cervical lesions. Methods: A total of 132 women, including 41 women diagnosed with normal cervical (NC), 39 patients with low-grade cervical intraepithelial neoplasia (CIN 1), 37 patients with high-grade cervical intraepithelial neoplasia (CIN 2/3) and 15 patients with cervical squamous cell carcinoma (SCC), who came from the gynecological clinic of Second Hospital of Shanxi Medical University during January 2018 to June 2018, were enrolled in this study according to the inclusive and exclusive criteria strictly. The vaginal flora was detected by 16S rDNA sequencing technology. Co-occurrence network analysis was used to investigate the Spearman correlations between different genera of bacteria. Results: The dominant bacteria in NC, CIN 1 and CIN 2/3 groups were Lactobacillus [constituent ratios 79.4% (1 869 598/2 354 098), 63.6% (1 536 466/2 415 100) and 58.3% (1 342 896/2 301 536), respectively], while Peptophilus [20.4% (246 072/1 205 154) ] was the dominant bacteria in SCC group. With the aggravation of cervical lesions, the diversity of vaginal flora gradually increased (Shannon index: F=6.39, P=0.001; Simpson index: F=3.95, P=0.012). During the cervical lesion progress, the ratio of Lactobacillus gradually decreased, the ratio of other anaerobes such as Peptophilus, Sneathia, Prevotella and etc. gradually increased, and the differential bacteria (LDA score >3.5) gradually evolved from Lactobacillus to other anaerobes. The top 10 relative abundance bacteria, spearman correlation coefficient>0.4 and P<0.05 were selected. Co-occurrence network analysis showed that Prevotella, Peptophilus, Porphyrinomonas, Anaerococcus, Sneathia, Atopobium, Gardnerella and Streptococcus were positively correlated in different stages of cervical lesions, while Lactobacillus was negatively correlated with the above anaerobes. It was found that the relationship between vaginal floras in CIN 1 group was the most complex and only Peptophilus was significantly negatively correlated with Lactobacillus in SCC group. Conclusions: The increased diversity and changed correlations between vaginal floras are closely related to cervical lesions. Peptophilus is of great significance in the diagnosis, prediction and early warning of cervical carcinogenesis.

Phytochemical interventions for post-traumatic stress disorder: A cluster co-occurrence network analysis using CiteSpace / 中西医结合学报

OBJECTIVE@#This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder (PTSD).@*METHODS@#The Web of Science database (2007-2022) was searched using the search terms "phytochemicals" and "PTSD," and relevant literature was compiled. Network clustering co-occurrence analysis and qualitative narrative review were conducted.@*RESULTS@#Three hundred and one articles were included in the analysis of published research, which has surged since 2015 with nearly half of all relevant articles coming from North America. The category is dominated by neuroscience and neurology, with two journals, Addictive Behaviors and Drug and Alcohol Dependence, publishing the greatest number of papers on these topics. Most studies focused on psychedelic intervention for PTSD. Three timelines show an "ebb and flow" phenomenon between "substance use/marijuana abuse" and "psychedelic medicine/medicinal cannabis." Other phytochemicals account for a small proportion of the research and focus on topics like neurosteroid turnover, serotonin levels, and brain-derived neurotrophic factor expression.@*CONCLUSION@#Research on phytochemicals and PTSD is unevenly distributed across countries/regions, disciplines, and journals. Since 2015, the research paradigm shifted to constitute the mainstream of psychedelic research thus far, leading to the exploration of botanical active ingredients and molecular mechanisms. Other studies focus on anti-oxidative stress and anti-inflammation. Please cite this article as: Gao B, Qu YC, Cai MY, Zhang YY, Lu HT, Li HX, Tang YX, Shen H. Phytochemical interventions for post-traumatic stress disorder: A cluster co-occurrence network analysis using CiteSpace. J Integr Med. 2023; 21(4):385-396.

Exploring Frailty and its Domains – Systematic Mapping of the Literature

Background: ‘Frailty’ has no consensual definition till date, although the term occupies a pivotal role in geriatric medicine. A bibliometric analysis of the literature serves to capture the keyword cooccurrences and linkages, co-citations, author collaborations, research trends and to present the extant research in a nutshell. Objective: To explore the usage of frailty, its domains in medical research and the evolution of the term to other disciplines through systematic mapping by bibliometric analysis. Methods: Literature search was done in the Scopus database using a pre-formed search strategy. 2629 documents were retrieved. Co-occurrence citation analysis using keywords and link strength was obtained using the VOSviewer ver.1.6.16. A three-field plot was constructed using ‘biblioshiny’ package of the R-studio to identify the various domains of frailty. Descriptive statistics were applied to identify the trends in frailty research, number of contributions from countries, fields of research involving frailty. Results: Total of 3739 publications were observed, with the USA having most number of contributions (740, 20%) as single country, while India has only 19 contributions (0.5%) in the past 20 years. As a region, Europe and Central Asia contributed to the maximum (1714, 46.4%), most of them being from the high-income countries. Research on frailty has steadily increased over the past two decades, with most of the researches being conducted in the fields of Medicine, Biochemistry and Genetics. Cooccurrence citations and three-field plots indicate the evolving usage of frailty in other domains, such as cognition, mental health, indicators of survival, risk assessment, mortality, and quality of life. Conclusion: Upon exploring frailty, it also makes one wonder if frailty could be the cause for what is known as death due to ‘natural causes’ or ‘old age’. The implementation of extension codes in the ICD-11 related to ‘Ageing’ (XT9T) and ‘Old Age’ (MG2A), paves way for researchers to further explore ‘frailty’ as a cause of mortality.

Current trends in research on pulmonary fibrosis and metabolites: A bibliometric analysis / 环境与职业医学

Background Certain metabolites are closely related to the occurrence and development of pulmonary fibrosis, and the related mechanism has not been fully elucidated. It is necessary to explore the trends of various metabolites and causes of pulmonary fibrosis. Objective To discuss the trends of publication and research hotspots of pulmonary fibrosis-related metabolites by bibliometrics. Methods With "pulmonary fibrosis" and "metabolites" in both Chinese and English as primary keywords, literature search was conducted through public online databases: PubMed, Web of Science, SinoMed, and CNKI. NoteExpress 3.0 and Excel 2019 were used to store and organize the collected literature. Analyses included publication year, number of papers, institution, country/region, and journal title. VOSviewer 1.6.10 was used for visual analysis. Keyword co-occurrence was analyzed by setting the minimum threshold for the occurrence of keywords to 5 times. Results The research on pulmonary fibrosis and associated metabolites in foreign language was earlier than that in Chinese language. Since the 1990s, the number of literature showed an increasing trend in both foreign and Chinese language literature. A total of 1 062 articles were published in foreign languages, of which 864 articles contained the authors’ address information. The authors in the United States published 340 articles, followed by China with 196 articles, and then Japan, Germany, and Italy. There were 728 relevant pieces of literature published in Chinese, 709 of which included the authors’ institution information and 350 institutions were involved. North China University of Science and Technology, Shanxi Medical University, Peking University, Zhengzhou University, China Medical University，and Soochow University were the top 6 by number of publication. A total of 255 Chinese journals published 728 Chinese articles, and among them 242 articles (33.24%) were published by 12 journals having published more than ten articles per journal. A total of 1062 articles were published in 609 foreign language journals, and among them 179 articles (16.85%) were published by 8 journals with more than 15 articles published by each journal. The results of keywords co-occurrence analysis suggested that pulmonary fibrosis in association with glucose metabolism, lipid metabolism, amino acid metabolism, nucleotide metabolism, and biological oxidation were the common themes studied at home and abroad. Conclusion The number of publications on pulmonary fibrosis and metabolites has been on the rise in recent years, and the research hotspots include glucose metabolism, lipid metabolism, amino acid metabolism, nucleotide metabolism, and biological oxidation.

Bibliometric-based analysis of characteristics and trend of global digestive endoscopy quality control / 中华消化内镜杂志

Objective:To analyze characteristics and trend of publications in digestive endoscopy quality control from 2010 to 2021.Methods:The literature on digestive endoscopy quality control from 2010 to 2021 were searched through the Web of Science core collection with the method of bibliometrics. The year of publication, journal name, country, main researchers, institutions and citations were analyzed by Web of Science. Then, the downloaded data were imported into VOSviewer for co-occurrence network analysis of the country, keywords and citations.Results:A total of 3 283 English papers on digestive endoscopy quality control were included. The number of papers from China and other countries showed an upward trend, and citations as well from 2010 to 2021. The publications were mainly from the United States (1 209, 36.8%), the United Kingdom (325, 9.9%), and China (324, 9.9%). The journal with the largest number of publications in this category was Gastrointest Endosc (241, 7.3%). The U.S. Department of Veterans Affairs had 175 publications, ranking the first among all institutions. Research topics were focused on colonoscopy, adenoma detection rate, and artificial intelligence. Conclusion:The research in digestive endoscopy quality control is booming, and the research activity is gradually increasing. Chinese academic influence in this field still needs to be further improved.

CiteSpace-Based Visualization Analysis of Forensic Research in China from 2010 to 2019 / 法医学杂志

OBJECTIVES@#To analyze the research status of forensic medicine in China from 2010 to 2019, obtain the development trend of forensic medicine and explore the hotspots and research frontiers.@*METHODS@#The forensic medical academic papers published on China National Knowledge Infrastructure (CNKI) database from 2010 to 2019 were collected. CiteSpace 5.7.R1, an information visualization analysis software, was used to analyze publication organizations, authors, keywords, and other elements.@*RESULTS@#The majority of the research institutions were universities, provincial and ministerial scientific research and forensic institutions. Forensic pathology was still an important branch of forensic medicine and a popular research direction. The "polymorphism" and "Y chromosome" had been the research hotspots in recent years. "Medical damage" and "standard" were the most novel studies.@*CONCLUSIONS@#In order to provide scientific basis and research direction for forensic research, this paper analyzes the cooperation network, research hotspots and research innovation in forensic research.

Research status and development trend of bibliometrics and visualization analysis in the assessment of femoroacetabular impingement / 中国组织工程研究

BACKGROUND: Exploring the research status and development trend of femomacetabular impingement, and finding out the research direction and hot spot of femomacetabular impingement are helpful for domestic scholars to grasp the latest information in this field and explore the most cutting-edge treatment direction. OBJECTIVE: To explore the research status and the development trend of femoroacetabular impingement in the world. METHODS: The science citation index of Wed of Science core collection was used to retrieve English literature on femoroacetabular impingement from January 1, 2005 to February 20, 2020. The bibliometric methods were used to conduct data statistics and analysis. Meanwhile, VOS viewer software was used for visualization conversion to analyze the research status and the development trend of femoroacetabular impingement. RESULTS AND CONCLUSION: (1) Totally 3 158 literatures were included. The literatures concerning global scientific research of femoroacetabular impingement are increasing year by year. The number of the United States published is largest. The United States makes the greatest contribution in the world, ranking the top (1 659 papers), whose number of the citations (37 019 papers) and H index (87 papers) are the highest. The number of literatures is 43 in China. It ranks 14 and the citations are 301; H index is 9. (2) ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY who contributed the largest number of relevant literatures (426 papers) is more than of the second magazine (287 papers) named AMERICAN JOURNAL OF SPORTS MEDICINE. UNIV BERN (University of Bern) and HOSP SPECIAL SURG (Hospital for Special Surgery) are two institutions which have the largest amount of research publications. (3) Currently, the research topics on femoroacetabular impingement are focusing on five areas, including epidemiology, disease progression, diagnosis, treatment and prognosis. In recent years, the primary field of research is treatment and the hip arthroscopic operation becomes a research hotspot. (4) From the analysis on the current development trend of femoroacetabular impingement, there is still very big exploration space in this area and the number of published literatures continuous increases. The United States remains a leader in this field. The further study is required in China. In recent years, the research direction focuses on the aspect of treatment of femoroacetabular impingement. Hip arthroscopic operation is research focus on femoroacetabular impingement.

Classification of glioma and solitary brain metastasis using magnetic resonance imaging radiomics feature / 解剖学报

Objective To analyze the difference of radiomics features between solitary brain metastasis and glioma using routine 3T TI, T2 and fluid attenuation inversion recovery (FLAIR) magnetic resonance imaging, to explore the significance of texture features constructed in different directions and angles in tumor regions in distinguishing the two kinds of tumors, and to explore a feasible method for high-precision classification of solitary brain metastases and gliomas. Methods Given the multimodal images of 43 patients with glioma and 45 age- and sex- matched patients with solitary brain metastasis, the gray level co-occurrence matrices of different angles of each slice were constructed from the transverse, coronal and sagittal directions of the tumor regions of these images, and the texture spatial relationship features (including contrast, correlation, energy and homogeneity) were calculated. Wilcoxon rank sum test was used to eliminate redundant features and select features with strong distinguishing ability. Finally, SVM linear kernel classifier was used to classify the selected features to achieve the identification of the two kinds of tumors. Results When classifying glioma and solitary brain metastasis, the precision, recall, Fl score and accuracy of multimodal and multidirectional combination features were 0.8857, 0.9114, 0.8944 and 0.8922, respectively. The area under the receiver operating characteristic curve obtained by linear kernel SVM classifier was 0. 9602. Totally 40 of the 45 patients with solitary brain metastases were correctly classified, and 39 of the 43 gliomas were correctly classified. Conclusion The multimodal and multi-directional combination features of tumor areas can be classified by linear kernel SVM classifier to distinguish gliomas from solitary brain metastases, which can be used as a second opinion to effectively assist doctors in making diagnosis.

Bibliometric Analysis of Forensic Genetics Literatures in SCIE from 1989 to 2019 / 法医学杂志

Objective To conduct bibliometric analysis of forensic genetics literatures published by Chinese mainland scholars in SCIE journals from 1989 to 2019, to show the research achievements of the past three decades and predict future research fields and directions. Methods Microsoft Office Excel 2019 was utilized to analyze the general situation, research institutions, authors, funds, author keywords, etc. of the literatures. The status of research in forensic genetics in Chinese mainland was visualized by PlotDB, Gephi 0.9.2 software and literature interpretation. Results During the last three decades, 1 126 forensic genetics literatures were published by scholars from Chinese mainland on SCIE journals, mostly articles. The quantity and quality of the literatures were both on the increase. The number of literatures published in Forensic Science International-Genetics was the highest, and 60.83% of the literatures were funded, mainly by the National Natural Science Foundation of China （498 literatures）. The current research hotspots were STR, SNP, InDel polymorphisms, linkage genetic markers, mtDNA genetic markers, epigenetic markers, RNA genetic markers, chip technology and omics research method. Conclusion The forensic genetics in China has developed rapidly along with the promotion of forensic science in universities. The SCIE literatures on forensic genetics published by Chinese mainland scholars increased rapidly with the funding from the National Natural Science Foundation of China and Ministry of Science and Technology of the People's Republic of China, which positively contributes to the development of basic research and the improvement of overall level in forensic genetics in China.

Research on innovation absorption of Chinese medicine industry based on K-shell decomposition / 中草药

Based on the patents authorized for inventions in the Chinese medicine industry from 2005 to 2016, a patent co-occurrence network is constructed using international patent classification (IPC) information; And based on the K-shell decomposition method to identify core technologies in the network, the technical structure, research hotspot, and the absorption of other technical topics in core areas of traditional Chinese medicine are analyzed. The absorption of innovation in different periods is further described to explore the development trend of the traditional Chinese medicine industry, technological growth points and the main areas of absorption of core technologies of traditional Chinese medicine, in order to provide references and suggestions for industry technological innovation of traditional Chinese medicine.

Bibliometrics analysis of community chronic disease management research based on literature co-occurrence analysis system / 药学实践杂志

Objective To investigate the current situation and existing problems of community chronic disease management in China and provide a theoretical basis for community chronic disease management to reduce the mortality and economic burden. Methods Research papers on community chronic disease management published in Chinese academic journal network from January 2010 to January 2020 were selected. Literature co-occurrence analysis system software, Bicomb2.0, and SPSS were used for data extraction and analysis based on publication years, geographical distribution, funding sources, etc. Results 1 427 papers were included. Most papers were published in the recent three years (2017—2019), with an average of 206.7 papers per year. 1 347 papers in Chinese (94.4%) and 80 in English (5.6%) were published in 436 journals, and 24.5% were funded. Hot topics are community health services, health management, diabetes and hypertension management, influencing factors. Conclusion Community chronic disease management has drawn a lot of attention in China. Economically well-developed provinces invested more on community chronic disease management. Universities are the main research institutions. Most researches are still at the exploratory stage.

Distribution of archaeal community in the mud pit during strong-flavor baijiu fermentation / 生物工程学报

Multi-species solid-state fermentation in a mud pit is one of the typical features of strong-flavor baijiu, in which archaea plays important roles, however, the archaeal community distribution and diversity during fermentation are still lack of research. The biomass, composition and succession of archaea communities in fermented grains and pit mud were analyzed by high throughput sequencing. The potential interaction between archaea and bacteria was analyzed by co-occurrence network. Results demonstrate that the average biomass of archaea in pit mud was about 200 times higher than that of fermented grains. There was no significant difference in archaeal community structure between fermented grains and pit mud (r=0.017, P=0.074), but succession patterns between them showed significant correlation (r=0.30, P=0.03). Methanobacterium was the most abundant archaea in fermented grains and pit mud, and other dominant groups included Methanosarcina, Methanocorpusculum, Methanoculleus, and Methanobrevibacter. The co-occurrence network analysis showed that Methanobacterium was positively correlated with most bacteria in fermented grains and pit mud, especially with Hydrogenispora and Caproiciproducens, the dominant bacteria in pit mud. Our results revealed the temporal and spatial distribution characteristics and potential functions of the archaeal community in the mud pit of strong-flavor baijiu.

Analysis of traditional Chinese medicine treatment of asthma from different syndrome based on literature / 国际中医中药杂志

Objective@#To explore the rules of TCM treatment of Asthma on different syndromes.@*Methods@#We searched the modern clinical literature of asthma treated by TCM form Chinese Clinical Literature Database, SinoMed, CNKI, Wanfang Database and CQVIP from 1949-2017, collected key information such as diseases, syndromes, and drug composition by human-computer integration and constructed a database. We calculated the co-occurrence matrix of syndrome-herb and the frequent item sets of herb for different syndromes using TCM Miner (http://tcmminer.cintcm.com:8023/tcm/index.jsp). The prescription and treatment of asthma with different syndrome were analyzed, and a new medicine prescription was proposed for common five kinds of common syndromes.@*Results@#There were 234 articles containing 124 syllables, 1 337 prescriptions and 290 herbs. For different syndromes, the high-frequency medicine was obviously different, which reflected the important ideas of TCM syndrome differentiation. According to five common syndromes including fever syndrome, cold syndrome, lung-spleen qi deficiency syndrome and kidney-yang deficiency syndrome, five new drug prescriptions have evolved.@*Conclusions@#Analysis of TCM prescriptions based on differentiating syndromes can explore the essence of TCM and provided ideas and data support for researchers.

Analysis of traditional Chinese medicine treatment of asthma from different syndrome based on literature / 国际中医中药杂志

Objective To explore the rules of TCM treatment of Asthma on different syndromes. Methods We searched the modern clinical literature of asthma treated by TCM form Chinese Clinical Literature Database, SinoMed, CNKI, Wanfang Database and CQVIP from 1949-2017, collected key information such as diseases, syndromes, and drug composition by human-computer integration and constructed a database. We calculated the co-occurrence matrix of syndrome-herb and the frequent item sets of herb for different syndromes using TCM Miner (http://tcmminer.cintcm.com:8023/tcm/index.jsp). The prescription and treatment of asthma with different syndrome were analyzed, and a new medicine prescription was proposed for common five kinds of common syndromes. Results There were 234 articles containing 124 syllables, 1 337 prescriptions and 290 herbs. For different syndromes, the high-frequency medicine was obviously different, which reflected the important ideas of TCM syndrome differentiation. According to five common syndromes including fever syndrome, cold syndrome, lung-spleen qi deficiency syndrome and kidney-yang deficiency syndrome, five new drug prescriptions have evolved. Conclusions Analysis of TCM prescriptions based on differentiating syndromes can explore the essence of TCM and provided ideas and data support for researchers.

Co-occurence analysis of intervention measures for pathological breast engorgement at home and abroad / 中国实用护理杂志

Objective Systematic review and analyze the domestic and foreign research literatures on interventional measures for pathological breast engorgement, and explore the differences between intervention measures for pathological breast engorgement at home and abroad, and provide reference and new ideas for further optimization of breast intervention measures in China. Methods Scientifically search the domestic and foreign research literatures on pathological breast engorgement intervention measures, import the search data into Citespace and VOS viewer to achieve co-occurrence analysis, and then systematically analyze the literature at the core node in the co-occurrence map. Results A total of 384 articles (267 foreign ones; 117 articles in China) were included in this study. The main themes of foreign research hotspots are: female, adult, first child, lymphedema, inflammation, breast basic diseases, breast tumors and time-influencing factors are mainly concerned with the exploration of high-risk influencing factors and early intervention of breast-related tumor diseases. Domestic research hotspots mainly focus on nursing interventions as the main intervention measures and effects evaluation. The content analysis in the core literature shows that foreign studies are mainly based on cohort studies, including the topical application of progesterone, psychological intervention, and breastfeeding time factors. Domestic research is mainly based on experimental research, mainly using massage techniques. Improvement, comparison of different external dressings as the main intervention. Conclusions At present, both domestic and foreign research have carried out active exploration and comparative research on the external materials and achieved certain results. The current study of postpartum breast engorgement in China needs to be further explored based on large samples and cohort studies.

Co-occurence analysis of intervention measures for pathological breast engorgement at home and abroad / 中国实用护理杂志

Objective@#Systematic review and analyze the domestic and foreign research literatures on interventional measures for pathological breast engorgement, and explore the differences between intervention measures for pathological breast engorgement at home and abroad, and provide reference and new ideas for further optimization of breast intervention measures in China.@*Methods@#Scientifically search the domestic and foreign research literatures on pathological breast engorgement intervention measures, import the search data into Citespace and VOS viewer to achieve co-occurrence analysis, and then systematically analyze the literature at the core node in the co-occurrence map.@*Results@#A total of 384 articles (267 foreign ones; 117 articles in China) were included in this study. The main themes of foreign research hotspots are: female, adult, first child, lymphedema, inflammation, breast basic diseases, breast tumors and time-influencing factors are mainly concerned with the exploration of high-risk influencing factors and early intervention of breast-related tumor diseases. Domestic research hotspots mainly focus on nursing interventions as the main intervention measures and effects evaluation. The content analysis in the core literature shows that foreign studies are mainly based on cohort studies, including the topical application of progesterone, psychological intervention, and breastfeeding time factors. Domestic research is mainly based on experimental research, mainly using massage techniques. Improvement, comparison of different external dressings as the main intervention.@*Conclusions@#At present, both domestic and foreign research have carried out active exploration and comparative research on the external materials and achieved certain results. The current study of postpartum breast engorgement in China needs to be further explored based on large samples and cohort studies.

Multi class disorder detection of magnetic resonance brain images using composite features and neural network

Brain disorder recognition has becoming a promising area of study. In reality, some disorders share similar features and signs, making the task of diagnosis and treatment challenging. This paper presents a rigorous and robust computer aided diagnosis system for the detection of multiple brain abnormalities which can assist physicians in the diagnosis and treatment of brain diseases. In this system, we used energy of wavelet sub bands, textural features of gray level co-occurrence matrix and intensity feature of MR brain images. These features are ranked using Wilcoxon test. The composite features are classifi ed using back propagation neural network. Bayesian regulation is adopted to fi nd the optimal weights of neural network. The experimentation is carried out on datasets DS-90 and DS-310 of Harvard Medical School. To enhance the generalization capability of the network, fi vefold stratifi ed cross validation technique is used. The proposed system yields multi class disease classifi cation accuracy of 100% in diff erentiating 90 MR brain images into 18 classes and 97.81% in diff erentiating 310 MR brain images into 6 classes. The experimental results reveal that the composite features along with BPNN classifi er create a competent and reliable system for the identifi cation of multiple brain disorders which can be used in clinical applications. The Wilcoxon test outcome demonstrates that standard deviation feature along with energies of approximate and vertical sub bands of level 7 contribute the most in achieving enhanced multi class classifi cation performance results.

The value of MRI texture analysis based on gray level co-occurrence matrix to predict cervical lymph node metastasis in tongue carcinoma patients / 中华放射学杂志

Objective To evaluate the value of MRI texture analysis based on gray level co-occurrence matrix to predict cervical lymph node metastasis in patients with tongue carcinoma. Methods A total of 70 patients with tongue carcinoma confirmed by pathology were analyzed retrospectively. The patients were divided into cervical lymph node (LN) metastasis group (unilateral LN+, n=18;bilateral LN+,n=22) and no cervical lymph node metastasis(LN-,n=30). T1W, T2W and contrast-enhanced T1W images of the largest section of tumor were selected. ROI of the lesion was manually drew and GLCM texture parameters (energy, contrast, correlation, inverse difference and entropy) were extracted. The tumor length, thickness and para-lingual distance between tumor and tongue midline were also measured.Differences of all parameters were compared between LN+ group and LN- group, unilateral and bilateral cervical lymph node metastasis group, the parameters with statistically significant difference in predicting the efficiency of cervical lymph node metastasis were analyzed. The diagnostic efficiency of lymph node metastasis was calculated. Results The correlation, inverse difference and entropy based on T2WI showed significant difference (Zcor elation=2.97, tinverse dif erence=5.14, tentropy=2.41; P<0.05), entropy showed the best diagnostic efficiency, the area under the ROC curve (AUC) was 0.90, the cut off value was 7.19, the sensitivity was 80.0％, specificity was 86.7％. Only entropy showed significant difference between unilateral LN+group and bilateral LN+group (P<0.05), the AUC was 0.82, the cut off value was 7.47, the sensitivity was 90.9％, specificity was 78.8％. The index of tumor length, thickness and para-lingual distance between tumor and tongue midline all showed significant difference between LN+group and LN-group (P<0.05), the thickness showed the best diagnostic efficiency, the AUC value was 0.81, the cut off value was 11.19, the sensitivity was 78.0％, specificity was 81.7％. The index of tumor length, thickness and para-lingual distance between tumor and tongue midline showed no significant difference between unilateral LN+ group and bilateral LN+ group (P>0.05). The diagnostic sensitivity of radiologists was 65.0％ (26/40), the specificity was 80.0％ (24/32) on cervical lymph node metastasis. Conclusion Texture analysis based on T2WI can predict cervical lymph node metastasis in patients with tongue carcinoma. Entropy has certain value in predicting bilateral cervical lymph node metastasis.

Multiple metastasis of follicular variant of papillary thyroid carcinoma coexistent with malignant melanoma

No abstract available.

Visualization Analysis on Diagnostic Criteria Research of Qi-yin Deficiency Based on Knowledge Mapping Function of CiteSpace / 世界科学技术-中医药现代化

Objective: To analyze the status and existing problems of the diagnostic criteria of qi and yin deficiencysyndrome by applying the knowledge mapping method. Methods: In the China Knowledge Network Database (CNKI), wesearched the relevant journal articles on the diagnostic criteria of qi and yin deficiency syndrome, exported andtransformed the literature data, and used CiteSpace software to draw co-occurrence map of authors, institutions and keywords of research on the diagnosis criteria of qi and yin deficiency syndrome for analysis.Results:A total of 378research papers were included, and the main researchers and teams represented by Li Jiansheng were found.The research institute was mainly the Institute of Geriatrics of Henan University of Traditional Chinese Medicine.Diabetes was the most concerned research direction in this field.Conclusion:Although the research on the diagnostic criteria of qi and yin deficiency syndrome is currently facing great difficulties, the research institutions in this field have cooperat extensively.The wisdom collision brought by such cooperation foundation will provide solutions to these problems, an the output of excellent results was expected.Based on diabetes, IGA nephropathy, coronary heart disease, and clinic research as the method, the relevant research is the main direction, which will be the main trend of the research on t diagnostic criteria of qi and yin deficiency syndrome.