ABSTRACT
AIM@#To evaluate the effect of Cocus nucifera L. flowers in reducing the major multiple symptoms of letrozole-induced polycystic ovarian disease (PCOD) in female rats.@*METHOD@#Female, virgin Wistar rats were treated with letrozole (1 mg/kg body wt) to induce PCOD, and after 21 days of induction rats were administered orally with 100 and 200 mg·kg(-1) of Cocus nucifera flower aqueous extract, respectively. Estrus cycle and blood sugar were monitored once a week throughout the study. After scarification, various biochemical parameters, such as antioxidant status (superoxide dismutase (SOD) and glutathione reductase (GSH)) of the uterus homogenate, lipid profile (total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), and triglycerides (TG)) of the serum were determined. Weights of the uterus and ovaries were separately monitored. The characteristics of changes in the ovary were evaluated by histopathological studies.@*RESULTS@#GC-MS analysis of the aqueous extract showed the presence of volatile and pharmacologically active phytoconstituents. C. nucifera flower extract-treated groups showed estrus cyclicity and increased uterus weight which indicates the estrogenic effect. The improved blood sugar level, ideal lipid profile, good antioxidant status, and histopathology results revealed the recovery from poly cystic ovaries.@*CONCLUSION@#The results indicate that C. nucifera flower is a potential medicine for the treatment of PCOD and this study supports the traditional uses of C. nucifera flower.
Subject(s)
Animals , Female , Antioxidants , Metabolism , Blood Glucose , Metabolism , Cocos , Chemistry , Estrus , Flowers , Chemistry , Gas Chromatography-Mass Spectrometry , Hypoglycemic Agents , Pharmacology , Therapeutic Uses , Letrozole , Lipids , Blood , Nitriles , Oils, Volatile , Pharmacology , Therapeutic Uses , Ovary , Pathology , Phytoestrogens , Pharmacology , Therapeutic Uses , Phytotherapy , Plant Extracts , Chemistry , Pharmacology , Therapeutic Uses , Polycystic Ovary Syndrome , Blood , Drug Therapy , Pathology , Rats, Wistar , Triazoles , UterusABSTRACT
Esta revisão apresenta os aspectos relevantes da água-de-coco, como os relacionados com sua composição química, valor nutritivo e propriedades funcionais, que aliadas a seu sabor adocicado, tornaram-na uma bebida muito apreciada, favorecendo o aumento do seu consumo. Também aborda as formas de comercialização da água-de-coco destacando-se os aspectos relacionados á industrialização que equilibram a oferta do produto ao longo do ano. Os fatores importantes durante o processamento da água-de-coco foram enfatizados e as pesquisas que vêm sendo realizadas para extensão de sua vida de prateleira e obtenção de produtos que mantenham o máximo possível suas características sensoriais originais
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