ABSTRACT
Cognitive decline in diabetes is the main manifestation of diabetic central neuropathy. Such cognitive decrements can be grouped as mild cognitive decline and dementia according to the disease severity, which would seriously threaten to the patients′ quality of late life. Current treatment is not able to reverse the dementia process, thus early diagnosis is essential. Sensory retrogression such as olfactory dysfunction seems to be an early warning indicator of the neurodegenerative diseases. Functional magnetic resonance imaging is an important tool for noninvasive detection of early brain pathophysiological changes. Therefore, the multidisciplinary cooperation among diabetes, neurocognition and neuroimage, and the construction of a quantitative assessment platform for olfactory function would be helpful to the early evaluation and diagnosis of cognitive decline in diabetes, and may also provide new ideas and targets for the early prevention and treatment of the cognitive complications in diabetes.
ABSTRACT
Cognitive decline in diabetes is the main manifestation of diabetic central neuropathy. Such cognitive decrements can be grouped as mild cognitive decline and dementia according to the disease severity, which would seriously threaten to the patients' quality of late life. Current treatment is not able to reverse the dementia process, thus early diagnosis is essential. Sensory retrogression such as olfactory dysfunction seems to be an early warning indicator of the neurodegenerative diseases. Functional magnetic resonance imaging is an important tool for noninvasive detection of early brain pathophysiological changes. Therefore, the multidisciplinary cooperation among diabetes, neurocognition and neuroimage, and the construction of a quantitative assessment platform for olfactory function would be helpful to the early evaluation and diagnosis of cognitive decline in diabetes, and may also provide new ideas and targets for the early prevention and treatment of the cognitive complications in diabetes.