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Alzheimer's disease is the most common cause of dementia.Current treatment options for Alzheimer's disease are very limited, and non-drug treatment is receiving more and more attention.Cognitive intervention is a relatively new non-drug treatment for Alzheimer's disease.A large number of previous studies have confirmed that cognitive intervention can prevent and mitigate clinical symptoms of Alzheimer's disease.In this review, we systematically introduce cognitive intervention as a prevention tool for Alzheimer's disease and its ability to alleviate clinical symptoms of the disease, and put forward suggestions for the future application of cognitive intervention in Alzheimer's disease.
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Abstract Aging entails many cognitive changes, including episodic memory, which may be potentiated depending on the lifestyle of the elderly person and stimulated through cognitive interventions. The objective of this study was to verify whether there are differences in episodic memory and mood in different interventions. A total of 46 elderly people, of both sexes, with an average age of 68.7 years (SD = ± 6.82) participated in the study, being divided in two groups, stimulation (Stimullus = 21) and training (MEMO = 25), and tests of diagnostic and memory measures were applied before and after intervention. A difference in episodic memory was observed between the interventions, as well as an improvement in their mood, regardless of the type of intervention.
Resumo O envelhecimento acarreta uma série de alterações cognitivas, incluindo a memória episódica, que pode ser potencializada a depender do estilo de vida do idoso e estimulada através de intervenções cognitivas. O objetivo desse estudo foi verificar se há diferenças relacionadas à memória episódica e ao humor em diferentes intervenções. Participaram do estudo 46 idosos, de ambos sexos, com idade média igual a 68,7 anos (Dp= ± 6,82). Foram divididos em dois grupos, sendo um estimulação (Stimullus = 21) e outro treino (MEMO = 25), e aplicados testes de medidas diagnósticas e de memória nos momentos pré e pós-intervenção. Foi observado que há diferença de memória episódica entre as intervenções e melhora no estado de humor, independentemente do tipo de intervenção.
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Objective To investigate the characteristics of cognitive impairment in critical patients, and to explore the role of early cognitive intervention training in improving cognitive impairment in critical patients. Methods A prospective cohort study was conducted. 133 patients in conscious and normal intelligence admitted to intensive care unit (ICU) of Hefei Second People's Hospital from January 2015 to June 2018 were enrolled. The patients were divided into control group (n = 66) and cognitive intervention group (n = 67) according to random number table based on chronological number for entry into the study. Cognitive function was assessed by Montreal cognitive assessment scale (MoCA scale) within 24 hours after ICU admission. The patients in the cognitive intervention group received a series of scientifically designed cognitive training sessions (playing electronic musical keyboard, learning simple Spanish, clock-drawing, psychological intervention) for 2 months, and follow-up was completed if the patient was discharged from ICU. While the patients in the control group did not undertake any cognitive training. After 2 months, the cognitive function of patients in both groups were assessed with MoCA scale. Subgroup analysis was conducted according to different age groups (20-40 years old, 41-60 years old, 61-80 years old) to explore the effect of cognitive intervention training in different age groups. According to the subjective evaluation of the patient's ability to live 2 months after cognitive intervention by the patient or his relatives, receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of the total score of MoCA for patients' ability to live after cognitive intervention. Results 133 critical patients were enrolled in the final analysis. There was no significant difference in gender, age, education, complications, ICU hospitalization, sedative or analgesic drug usage between the two groups, indicating that the data of the two groups were balanced and comparable. No significant difference in MoCA scale total score or sub-item cognitive domain score within 24 hours of ICU admission was found between the two groups. After 2 months of intervention, the incidence of cognitive impairment in the cognitive intervention group was significantly lower than that in the control group [38.8% (26/67) vs. 60.6% (40/66), χ2 = 6.321, P = 0.015]. The total score of MoCA scale and four sub-item cognitive domain scores including visual space and execution power, protection of memory, attention execution, and orientation in the cognitive intervention group were significant higher than those in the control group (MoCA scale total score: 26.73±1.92 vs. 24.95±2.26, visual space and executive power score: 4.39±0.70 vs. 3.95±0.88, protection of memory score: 8.91±1.03 vs. 8.24±1.37, attention execution score: 5.21±0.77 vs. 4.79±1.00, orientation score: 5.67±0.53 vs. 5.44±0.68, all P < 0.05), but no significant difference was found in verbal skills score (2.55±0.56 vs. 2.53±0.56, P > 0.05). Subgroup analysis showed that the total MoCA scale score of the younger sample (20-40 years old, n = 20) was recovered by 2.10±1.55 in the cognitive intervention group after 2 months of cognitive intervention, which was significantly higher than that in the control group (n = 21; 0.24±2.76, P < 0.05). In the middle-aged and the older population [aged 41-60 years old (n = 20) and 61-80 years old (n = 27)], the total MoCA scale scores were recovered slightly after cognitive intervention as compared with those in the younger sample (0.43±1.47, -1.91±2.20 vs. 2.10±1.55, both P < 0.05), which were significantly lower than those in the control group [aged 41-60 years old (n = 21) and 61-80 years old (n = 24), -0.78±1.38, -4.41±2.17,both P < 0.01]. It was suggested that cognitive intervention training played an active role in the recovery of cognitive function in young critical patients. It was shown by ROC curve analysis that the area under ROC curve (AUC) of MoCA scale total score for predicting daily life ability after cognitive intervention was 0.732 with 95% confidence interval (95%CI) of 0.646-0.819. When the best cut-off value was 24.5, the sensitivity was 89.3%, the specificity was 60.2%, the positive predictive value was 85.7%, and the negative predictive value was 80.8%. Conclusions Early cognitive intervention could efficiently abate the deterioration of cognitive function in critical patients in ICU and had significant effects on the visual space and executive power, protection of memory, attention execution and orientation. Cognitive intervention exerted significantly positive effects on the recovery of cognitive function in the younger sample population (aged 20-40 years old).
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OBJECTIVE: The aim of this study is to investigate the effects of cognitive training and cognitive trainer on cognitive function in persons with mild cognitive impairment (MCI). METHODS: A randomized controlled single blind trial with 2 treatment groups was designed and 40 participants were included in this study. They received cognitive training intervention by cognitive professional and non-professional. The cognitive training focused on memory strategies. This cognitive intervention consisted of 8 sessions training and once a week. The effect of program was examined in performance-based measures of cognitive abilities; memory, language, constructional praxis, attention, and working memory. The comparison of effect of trainer was examined by repeated measure analysis of variance. RESULTS: Thirty-six MCI completed the cognitive intervention and was assessed neurocognitive test on pre- and post-intervention. Attention, language inhibition and semantic language were significantly improved compared with baseline in total group. The memory (p=0.003) was significantly improved in Professional Program Group and attention (p=0.007) was significantly improved in Non-Professional Program Group (NPG). Distinctively, Korean version of Short form of Geriatric Depression Scale mean score in NPG was statistically improved from 4.24 to 3.29 (p=0.018) after intervention, but the comparison between groups was not significant. CONCLUSION: This study shows that the cognitive intervention program may improve on memory, attention and language in cognitive functions of MCI. But there is difference in improvement of the domains of cognitive abilities depending on the trainer.
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Humans , Cognition , Depression , Memory , Memory, Short-Term , Cognitive Dysfunction , SemanticsABSTRACT
Mild cognitive impairment is the intermediate state between normal aging and dementia, which is considered as the best intervention window period to delay or reverse cognitive impairment. This pa-per summarizes the cognitive training techniques and challenges in Community-dwelling Elderly with mild cognitive impairment,which includes strategy-based cognitive train,process-based cognitive train,multi-mode comprehensive train,computer-aided cognitive train,and in order to provide theoretical support for the prac-tice of cognitive training.
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Compared with age-matched controls,mild cognitive impairment (MCI) populations are at a higher risk of developing Alzheimer's disease (AD).There is no consensus that any pharmacological treatment can improve MCI,thus it is plausible to turn attention to cognitive interventions.This paper reviewed the prior researches on cognitive stimulation,cognitive training,and cognitive rehabilitation for MCI based on the categories defined by Clare and Woods in order to clarify the effect of these interventions on improving cognitive function in MCI individuals.The results indicate that cognitive interventions may improve multiple cognitive domains including memory performance,executive functions,processing speed,attention,and social functions in adults with MCI,while the mechanism remains unclear.It suggested that further studies should examine the mechanism of cognitive intervention by applying neuroscience technology and strengthening the control of heterogeneity of the etiologies and symptoms of MCI,and improve the clinical effect by combining cognitive stimulation,cognitive training,and cognitive rehabilitation.
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0bjective The cognitive intervention effects of different forms of virtual reality technology in mild cognitive impairment (MCI) patients were systematically evaluated to find the best form of virtual reality intervention in MCI patients. Methods The computer searched of CNKI, Wanfang, VIP, CBM, PubMed, Embase and Cochrane Library included literatures on virtual reality technology intervention for MCI patients for evaluation. Results 5 randomized controlled trials were included, a total of 232 participants were in, the intervention group was 115 participants,control group was 117 participants, the results showed that virtual reality memory training had greatly improved cognitive function (P<0.01), Virtual reality program training, double interactive virtual reality technology therapy and virtual reality rehabilitation training system combined with primary meridian acupuncture therapy can improve the cognitive ability of MCI patients (P<0.05). The virtual reality dual task training has no statistical significance for the improvement of cognitive function (P>0.05). Conclusions Virtual reality technology intervention for MCI patients is an effective way to improve the cognitive ability of patients.
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This study aimed to investigate the effects of a memory training (MEMO) and a memory stimulation (Stimullus) procedure in older adults with normal cognitive aging. The study was conducted with 44 participants of both sexes, healthy and over 60 years old, using a randomized control trial design with two groups receiving cognitive interventions and one control group with no intervention, with pre and post-intervention assessments. Results indicated that MEMO interventions produce more cognitive gains than the Stimullus intervention procedure. Visual memory and Face-Name Association tests presented significant differences between groups, but Free Recall and Image Recognition tests were insensitive to the interventions.
Este estudo investigou os efeitos de um treino de memória (MEMO) e de uma estimulação da memória (Stimullus) em idosos com envelhecimento cognitivo normal. O estudo foi realizado com 44 participantes de ambos os sexos, saudáveis e com mais de 60 anos de idade. Aplicou-se um delineamento controlado randomizado com dois grupos que receberam intervenções cognitivas e um grupo controle sem intervenção, com avaliações pré e pós-intervenção. Os resultados demonstraram que a intervenção do tipo MEMO produziu mais ganhos cognitivos do que Stimullus. O teste de memória visual e o teste de associação nome-rosto apresentaram diferenças significativas entre os grupos, mas os testes de recuperação livre de palavras e reconhecimento de imagens não foram sensíveis às intervenções.
Este estudio investigó los efectos de un entrenamiento de la memoria (MEMO) y una estimulación de la memoria (Stimullus) en pacientes de edad avanzada con el envejecimiento cognitivo normal. El estudio se realizó con 44 participantes de ambos sexos, saludables y con más de 60 años. Se aplicó un diseño aleatorizado controlado con dos grupos que recibieron las intervenciones cognitivas y un grupo de control sin intervención, con las evaluaciones previas y posteriores a la intervención. Los resultados mostraron que la intervención del tipo MEMO produjo más beneficios cognitivas que Stimullus. La prueba de memoria y asociación rostro-nombre visual mostró diferencias significativas entre los grupos, pero las pruebas de recuperación de palabras e reconocimiento de imágenes no fueron sensibles a las intervenciones.
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Humans , Male , Female , Middle Aged , Aged , Aged/psychology , Aging/psychology , Cognition , Memory and Learning Tests , Memory , Psychological Tests , Brazil , Statistics, NonparametricABSTRACT
Objective: To discuss the applied effect of high frequency repetitive transcranial magnetic stimulation combined with cognitive intervention for stroke patients with aphasia. Methods: 84 stroke patients with aphasia were divided into observation group (42 cases)and control group (42 cases). Patients of control group were treated by routine intervention of language training, while patients of observation group were treated by high frequency repetitive transcranial magnetic stimulation combined with cognitive intervention. A series of evaluated indicators, such as the language function score of Boston diagnostic aphasia examination(BDAE), the anxiety symptom score of Hamilton anxiety scale(HAMA), the quality of life and degree of satisfaction, were adopted to compare the post-treatment effect for the two groups. Results: After the treatment, there were statistical significance in the difference of understanding, retelling ability, reading ability and writing ability about BDAE scores between the two groups (t=3.572, t=4.482, t=6.238, t=3.013; P<0.05), and the HAMA scores of observation group was significant higher than those of control group (t=3.472, P<0.05). Besides, through different interventions, the series of indicators about quality of life, such as physical function, mental function, social function and material function, of observation group were higher than those of control group (t=4.513, t=3.923, t=4.473, t=4.033; P<0.05). And the satisfaction of observation group was significant higher than that of control group (x2=5.233, P<0.05). Conclusion: The clinical effect of high frequency repetitive transcranial magnetic stimulation combined with cognitive intervention for stroke patients with aphasia is favorable. And this method can increase quality of life and satisfaction for patients, and can extremely reduce medical dispute and improve the therapeutic level of hospital for stroke patients with aphasia.
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BACKGROUND: Cognitive intervention (CI) is a nonpharmacological approach used to compensate for cognitive impairment. It is categorized into cognitive training, cognitive stimulation and cognitive rehabilitation. Several studies showed that CI could induce cognitive enhancement and reduction of risk for future cognitive decline in patients with brain injury. We investigated effects of CI on cognitive functions and brain glucose metabolism based on serial cognitive assessments and [18F]-Fluorodexoxyglucose positron emission tomography (FDG-PET) in a patient with carbon monoxide (CO) intoxication. METHODS: A 40-year-old man presented with memory impairment and abnormal behaviors such as apathy, indifference, and perseveration 2-month after CO intoxication. Brain magnetic resonance image (MRI) demonstrated high signal changes in the bilateral basal ganglia, hippocampus and the subcortical white matter on T2 weighted images. FDG-PET also showed glucose hypometabolism in the bilateral hippocampus, basal ganglia, and the subcortical white matter. A detailed neuropsychological evaluation revealed multiple cognitive impairments in memory, language and frontal functions. He received twice a week sessions of 60-minute group-based cognitive intervention for 12 weeks. Several neuropsychological examinations and FDG-PETs were conducted at baseline and after CI. RESULTS: After CI, he showed improvements in memory and frontal functions compared with baseline performances. These cognitive improvements persisted by the 7-month follow-up. The extent of glucose hypometabolism was decreased 1-month after CI, however increased 8-month after CI. CONCLUSIONS: This case study suggested that CI could enhance cognitive functions and improve glucose metabolism in a patient with CO intoxication. Also, the effects of CI on cognitive functions seem to be last at least 7-month after training.
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Adult , Humans , Apathy , Basal Ganglia , Brain , Brain Injuries , Carbon Monoxide , Follow-Up Studies , Glucose , Hippocampus , Memory , Metabolism , Neuronal Plasticity , Neuropsychology , Positron-Emission Tomography , RehabilitationABSTRACT
La intervención cognitiva es importante como parte del tratamiento no farmacológico en los pacientes con deterioro cognitivo ligero y demencia leve. Esta investigación ofrece diferentes técnicas, instrumentos y métodos que incluye la referida terapéutica, lo que necesariamente contribuye al quehacer humano del personal médico y paramédico
The cognitive intervention is important as part of the non-pharmacological treatment in patients with mild cognitive deterioration and mild dementia. This investigation provides different techniques, tools and methods including therapy, which necessarily contributes to human activity of the medical and paramedical staff
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Humans , Cognition Disorders , Cognitive Behavioral Therapy , Dementia , Psychiatric Somatic Therapies , Psychotherapy , Neurocognitive DisordersABSTRACT
Although acetylcholinesterase inhibitors (e.g., tacrine, donepezil, rivastigmine, and galantamine) and NMDA receptor antagonists (e.g., memantin) have demonstrated efficacy in the temporal symptomatic control of cognitive decline and daily function in Alzheimer's disease (AD) patients, their effect is not good enough to restore premorbid function, nor is it maintained in the later stages. Therefore, nonpharmacological interventions are being increasingly advocated in order to optimize the cognition, affect and global functioning of AD patients. We reviewed the current nonpharmacological interventions for AD. Nonpharmacological interventions can be divided into two groups. One is cognitive interventions (e.g., Memory rehabilitations, Reality orientation, Reminiscence therapy and so on) and the other is behavioral interventions (e.g., unmet needs interventions, learning and behavioral interventions, environmental vulnerability and reduced stress-threshold interventions). Cognitive interventions are aimed to slow and compensate cognitive decline of AD patients. On the other hand, behavioral interventions are aimed to reduce neuropsychiatric symptoms (depression, anxiety, agitation, wandering, aggression and so on) of AD patients. Although many of the nonpharmacological interventions have proven beneficial for AD patients, their efficacy was still ambiguous. Randomized and controlled study with a larger sample size is needed to confirm efficacy of nonpharmacological interventions.
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Humans , Aggression , Alzheimer Disease , Anxiety , Cholinesterase Inhibitors , Cognition , Dihydroergotamine , Hand , Indans , Learning , Memory , N-Methylaspartate , Orientation , Phenylcarbamates , Piperidines , Rivastigmine , Sample Size , TacrineABSTRACT
PURPOSE: The purpose of this study was to examine the effects of cognitive intervention on myths about the uterus and anxiety in women undergoing a hysterectomy. METHOD: Subjects were admitted to G hospital in Busan for a hysterectomy. Of the subjects, 37 were in the experimental group and 36 were in the control group. Data was collected from December 1st, 2005 to February 28th, 2006. A hand-out, including knowledge about the uterus and the healing process, was used in the cognitive intervention. The tool for myths about the uterus had 10 questions developed by a researcher from previous research. In addition, the levels of anxiety(STAI) were measured. The data was analyzed by chi-square-test, t-test, paired t-test, and pearson correlation coefficient with the SPSS 12.0/pc program. RESULTS: After providing cognitive intervention, the level of belief in the myths about the uterus of the experimental group decreased significantly more than the control group. In addition, the level of anxiety of the experimental group decreased significantly more than the control group. There is a significant correlation between the myth about the uterus and anxiety. CONCLUSION: Cognitive intervention is a useful nursing intervention that decreases anxiety in women undergoing a hysterectomy. It is recommended to further use the appropriate cognitive intervention in nursing practice.
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Female , Humans , Anxiety , Hysterectomy , Nursing , UterusABSTRACT
OBJECTIVES: This study was designed to evaluate clinical effect of paroxetine treatment and to explore psychological predictors of treatment response. METHODS: Patients (n=26) who met DSM-IV criteria for panic disorder with or without agoraphobia were treated by paroxetine for 12 weeks. We assessed symptom improvement using Clinical Global Impression (CGI), and clinical characteristics using Anxiety Sensitivity Index (ASI), Anxious Thoughts and Tendencies (AT & T), Agoraphobic Cognition Questionnaire (ACQ), Body Sensation Questionnaire (BSQ), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). T-test, correlation analysis, and stepwise multiple regression analysis were performed. RESULTS: Panic patients showed significant improvement in severity of illness and each clinical characteristic after 12 weeks of paroxetine treatment. There were significant correlations among severity of illness, anxiety, and depression, and subjective severity was related with catastrophic thoughts. The more catastrophic thoughts and the higher sensitivity of body sensation, Patients had the worse symptom improvement they shorved. Multiple regression analysis showed that catastrophic thought related to agoraphobia was the best predictor of symptom improvement (22%). CONCLUSION: This study suggests that short-term treatment of paroxetine is effective in panic disorder with or without agoraphobia, and that catastrophic thought could be a predictor of poor treatment response. Thus cognitive intervention on catastrohic thoughts may play an important role in symptom improvement in panic disorder.
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Humans , Agoraphobia , Anxiety , Cognition , Depression , Diagnostic and Statistical Manual of Mental Disorders , Panic Disorder , Panic , Paroxetine , Surveys and Questionnaires , SensationABSTRACT
Objective: To investigate the effect of cognitive intervention on the therapy to Chronic prostatitis(CP) following Sexually Transmitted Diseases(STD). Methods: 84 patients were divided into two groups, as control group(n=42) in which prostant was locally used and the intervention group(n=42) which received cognitive Intervention therapy based on the locally using prostant. After a month, the therapy effect was evaluated. Results: Compared with control group, the subjective syndrome in intervention group was improved much more apparent receiving therapy one month later(P 0.05). Conclusion: Cognitive intervention is an effective method to improve the subjective syndrome of CP following STD; so a clinical medicine should study psychology.