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Colorectal cancer is a disease with high morbidity and mortality. Colorectal cancer has a poor prognosis, duing to the current limited treatment methods and can not achieve satisfactory treatment results. Therefore, how to diagnose colorectal cancer patients early and improve the prognosis has always been one of the problems in the medical and scientific research circles. As researchers gradually learn more about the intestinal flora including Fusobacterium nucleatum, the targeted treatment has been applied to the experimental research and clinical treatment of colorectal cancer. This paper reviews the research progress of Fusobacterium nucleatum on the pathogenesis, early diagnosis, prognosis and treatment of colorectal cancer in recent years.
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Objective:To investigate the incidence and influencing factors of parastomal hernia in patients with permanent colostomy.Methods:The retrospective cohort study was conduc-ted. The clinicopathological data of 72 patients with permanent colostomy in the Beijing Friendship Hospital of Capital Medical University from January 2016 to June 2020 were collected. There were 50 males and 22 females, aged (66±12)years. Observations indicators: (1) follow-up; (2) analysis of factors affecting the incidence of parastomal hernia; (3) comparison of the incidence of parastomal hernia in patients with different age. Follow-up was conducted using outpatient examination. Patients were followed up once every 12 months after surgery to detect the incidence of parastomal hernia up to September 2021. Measurement data with normal distribution were represented as Mean± SD, and comparison between groups was conducted using the t test. Measurement data with skewed distribution were represented as M(range). Count data were expressed as absolute numbers and percentages, and comparison between groups was conducted using the chi-square test. Univariate analysis was conducted using the corresponding statistical methods based on data type. Multivariate analysis was conducted using the Logistic regression model. Kaplan-Meier method was used to draw the parastomal hernia occurrence curve and calculate the incidence rate of parastomal hernia and Log-rank test was used to analyze the incidence of parastomal hernia. Results:(1) Follow-up. All 72 patients were followed up for 23(range, 12?76)months. During the follow-up, there were 31 patients developed parastomal hernia, with the incidence as 20.8%(15/72), 36.1%(26/72) and 43.1%(31/72) at postoperative 1 year, postoperative 2 year and postoperative 5 year, respectively. Of the 31 patients with parastomal hernia, there were 21 cases of type Ⅰ, 3 cases of type Ⅱ and 7 cases of type Ⅲ. Patients with parastomal hernia recovered with conservative treatment. (2) Analysis of factors affecting the incidence of parastomal hernia. Results of univariate analysis showed that age, subcutaneous fat thickness and rectus abdominis thickness were related factors affecting the incidence of parastomal hernia ( χ2=7.98, t=?2.95, 2.02, P<0.05). Results of multivariate analysis showed that age, subcutaneous fat thickness and rectus abdominis thickness were independent factors affecting the incidence of parastomal hernia ( odds ratio=4.07, 3.19, 0.07, 95% confidence interval as 1.46?11.32, 1.43?7.09, 0.01?0.84, P<0.05). (3) Comparison of the incidence of parastomal hernia in patients with different age. Of the 72 patients, there were 37 cases with age <65 years and 35 cases with age >65 years. Of the 31 patients with parastomal hernia, there were 10 cases with age<65 years and all of them with type Ⅰ parastomal hernia, and the incidence of parastomal hernia in postoperative 1 year and postoperative 2 year was 13.5%(5/37) and 27.0%(10/37), respectively. There were 21 cases with age ≥65 years and cases with type Ⅰ, type Ⅱ and type Ⅲ parastomal hernia were 11, 3 and 7, respectively. The postoperative 1 year and postoperative 2 year incidence of parastomal hernia in the 21 cases was 28.6%(10/35) and 45.7%(16/35), respectively. There was a significant difference in the incidence of parastomal hernia between patients<65 years and ≥65 years ( χ2=9.28, P<0.05). Conclusion:Age, subcutaneous fat thickness and rectus abdominis thickness are independent factors affecting the incidence of parastomal hernia.
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Bacteroides fragilis (BF) is a symbiotic bacterium in human intestine, and has a variety of effect on intestinal environment. BF can be divided into enterotoxigenic Bacteroides fragilis (ETBF) and nontoxigenic Bacteroides fragilis (NTBF). ETBF can lead to diarrhea, colitis, inflammatory bowel disease and colorectal cancer, while NTBF has a protective effect on intestinal homeostasis. NTBF not only can provide nutritional support for other microorganisms, but also enhance the anti-inflammatory effect of immune cells. This article reviewed the effect of BF on colorectal diseases and prospect of microflora therapy.
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Intestinal microbes play a vital role in the development of colorectal diseases.Fusobacterium nucleatum (Fn), an commensal resident in the human gut, is closely associated with colorectal diseases, and attracted widespread attention.Studies have found that Fn may contribute to the development and prognosis of inflammation and colorectal cancer.This article reviews the research advances of the relationship between Fn and the development of colorectal diseases.
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Introdução: a colonoscopia faz parte da rotina na investigação de crianças com sangramento retal, suspeita de doença inflamatória intestinal, diarreia crônica e outros sintomas abdominais. Objetivos: este estudo tem, como objetivo, quantificar o número de endoscopias realizadas e estabelecer o perfil das crianças que tiveram a indicação de realizar colonoscopia no Hospital Infantil Dr. Juvêncio Mattos no Maranhão, bem como sua relação com a queixa principal, os achados endoscópicos e o tratamento. Metodologia: trata-se de um estudo analítico e transversal com 32 crianças de 8 a 13 anos, que foram submetidas à colonoscopia no Hospital Infantil Dr. Juvêncio Mattos, de janeiro de 2010 a fevereiro de 2012. Resultados: observou-se 37 achados endoscópicos e histopatológicos uma vez que cinco pacientes apresentavam duas patologias associadas. Foi diagnosticada Doença de Crohn em duas crianças e retocolite ulcerativa inespecífica em quatro crianças. Oito pacientes apresentavam hiperplasia nodular linfoide. Evidenciou-se ainda quatro casos de colite alérgica e um caso de colite relacionada à oxiuríase. Houve também retocolite associada à hiperplasia nodular linfoide em uma criança com síndrome de cutis laxa. Os pólipos foram achados em 10 pacientes, sendo os mais frequentes principalmente entre as idades de 1 a 5 anos. Em sete pacientes, a colonoscopia foi normal. Conclusão: desta forma, a colonoscopia vem se firmando como um método adequado para o diagnóstico de lesões colorretais e tendo, inclusive, o valor terapêutico em alguns casos.
Introduction: the colonoscopy is part of the routine investigation of children with rectal bleeding and suspected inflammatory bowel disease, chronic diarrhea and other abdominal symptoms. Objective: this research aims to quantify the number of endoscopies performed and establish the profile of the children who had the indication to perform colonoscopy at Childrens Hospital Dr. Juvêncio Mattos and his relationship with the chief complaint, endoscopic findings and treatment. Methods: it is a study analytical, cross with 32 children from three months to thirteen years old who underwent colonoscopy at Childrens Hospital Dr. Juvêncio Mattos from January 2010 to February 2012. Results: there were 37 endoscopic and histopathological findings, since five patients had two comorbidities. Crohns disease was diagnosed in two children and ulcerative colitis in four children. Eight patients had nodular lymphoid hyperplasia. It was also revealed four cases of allergic colitis and one case of colitis-related oxyuriasis. There have also been associated with colitis nodular lymphoid hyperplasia in a child with Cutis Laxa Syndrome. Polyps were found in 10 patients, the most frequent, mainly between the ages 1-5 years. In seven patients, colonoscopy was normal. Conclusion: thus, the colonoscopy has been established itself as a suitable method for the diagnosis of colorectal lesions and in some cases, therapeutic value.
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Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Health Profile , Colonoscopy , Child Health , Cross-Sectional Studies , Colonic Diseases , GastroenterologyABSTRACT
Os autores analisaram, retrospectivamente, uma análise de 504 colonoscopias ambulatoriais, realizadas no período de junho de 2008 a maio de 2009, no Centro de Especialidades Médicas da Santa Casa de Belo Horizonte, pelo Grupo de Coloproctologia da Santa Casa de Belo Horizonte e Faculdade de Ciências Médicas de Minas Gerais (CPG). Dentre as observações retiradas do estudo, merecem destaques especiais as análises de sexo, faixas etárias, especialidade dos médicos solicitantes, indicações de colonoscopias, preparo intestinal utilizado, altura atingida pela colonoscopia, achados colonoscópicos e complicações do exame. Quanto ao sexo, 67 por cento (337) eram mulheres e 33 por cento (167) homens, e quanto às faixas etárias, sobressaiu a sexta (130 pacientes; 26 por cento) e a sétima (113 pacientes; 22 por cento). O exame foi autogerado pelo próprio grupo em 79,56 por cento (401 colonoscopias), sendo as indicações mais comuns o sangramento baixo (76 casos; 13,0 por cento) e controle de pacientes submetidos à cirurgias para abordagem de câncer colorretal (70 casos; 12,0 por cento). O preparo intestinal foi feito com manitol, lactulose e picossulfato de sódio, de acordo com o estado clínico do paciente, ensejando 71 por cento (359 casos) de resultados excelentes. A colonoscopia atingiu o ceco em 445 pacientes (88,0 por cento), tendo chegado ao íleo terminal em 293 casos (58,0 por cento). Os achados colonoscópicos principais foram os pólipos (163 casos; 28,0 por cento), seguidos pelo exame normal (149 casos; 26,0 por cento) e doença diverticular dos cólons (141 casos; 24,0 por cento). Dos 151 pólipos que tiveram suas dimensões assinaladas, 130 pólipos tinham o maior diâmetro menor que 10 mm (86,0 por cento). Dos 207 exames histopatológicos realizados, seja em ressecções seja em biópsias, o pólipo foi o achado mais comum (163 casos; 78,8 por cento), e dos 163 pólipos ressecados o achado mais comum foram os adenomas com displasia de baixo grau (116 casos; 71,2 por cento)...
The authors retrospectively analyzed 504 outpatient undergoing colonoscopy, performed from June 2008 to May 2009, in the "Center for Medical Specialties" of Santa Casa de Belo Horizonte, by the Group of Coloproctology of Santa Casa de Belo Horizonte and School of Medical Sciences of Minas Gerais (CPG). The study deserve special highlights the analysis of gender, age, specialty of referring physicians, indications of colonoscopy, bowel preparation used, height achieved by colonoscopy and colonoscopic findings. Regarding gender, 67 percent (337) were women and 33 percent (167) men, and as to age, stood sixth (130 patients, 26 percent) and seventh (113 patients, 22 percent). The examination was self-generated by the GCP in 79.56 percent (401 colonoscopies) and the most common indications were low bleeding (76 cases, 13.0 percent) and control patients undergoing surgical approach to colorectal cancer (70 cases; 12.0 percent). Bowel preparation was done with mannitol, lactulose and sodium picosulphate, according to the clinical status, allowing for 71 percent (359 cases) of excellent results. Colonoscopy reached the cecum in 445 patients (88.0 percent), having reached the terminal ileum in 293 cases (58.0 percent). The main findings were polyps (163 cases, 28.0 percent), followed by normal findings (149 cases, 26.0 percent) and diverticular disease of the colon (141 cases, 24.0 percent). Of the 151 polyps that had marked its size, 130 polyps were the largest diameter less than 10 mm (86.0 percent). Of 207 histopathological examinations performed, either in biopsies or in polyp resection, the polyp was the most common finding (163 cases, 78.8 percent), and among the 163 polyps resected the most common finding was the adenoma with low grade dysplasia (116 cases ; 71.2 percent). There were no complications. The data were compared with some published reports, all within the usual standards.