ABSTRACT
Adjuvants enhance the efficacy of the vaccine by regulating or enhancing the immune response to antigens,helping to reduce the amount of antigen and improve the vaccine safety.With the deepening of adjuvant researches,it has been found that the combination of two or more adjuvants can produce synergistic effects by activating multiple immune mechanisms.Highly effective vaccines are urgently needed for the group with pathogens that are difficult to remove and with low immune system function.This requirement can be met by the combination of immunologic adjuvants.In this paper,the progress of some new adjuvants and the applications of combined adjuvants were reviewed including liposomes,immunostimulating complexes,Montanides,polycationic peptide IC31,nanoemulsion and AS adjuvant systems.