ABSTRACT
PURPOSE: To report a case of keratitis caused by Acinetobacter baumannii and Candida parapsilosis in a patient using 0.5% levofloxacin and 0.1% fluorometholone for an extended period of time. CASE SUMMARY: A 55-year-old male patient in the neurosurgery department with conjunctival injection and discharge in his left eye was consulted for ophthalmic evaluation and treatment. He was hospitalized in the state of akinetic mutism and given 0.5% levofloxacin and 0.1% fluorometholone for 2 years. On slit-lamp examination, a 3.5 x 4.5-mm dense stromal infiltrate with an overlying epithelial defect was observed. Corneal scraping culture revealed multidrug-resistant A. baumannii and C. parapsilosis. According to the susceptibility result, the patient was treated with topical 10% piperacillin/tazobactam and 0.125% amphotericin B hourly. The corneal ulcer healed gradually with corneal opacity remaining after 8 weeks of treatment. CONCLUSIONS: The authors of the present study report a case of treated multidrug-resistant A. baumannii and C. parapsilosis keratitis in a patient using topical antibiotics and steroid for an extended period of time.
Subject(s)
Humans , Male , Middle Aged , Acinetobacter , Acinetobacter baumannii , Akinetic Mutism , Amphotericin B , Anti-Bacterial Agents , Candida , Corneal Opacity , Corneal Ulcer , Eye , Fluorometholone , Keratitis , Neurosurgery , OfloxacinABSTRACT
PURPOSE: Pyogenic spinal infection encompasses a broad range of clinical entities, treatment and prognosis. We compared the symptoms and treatment efficacy of patients with single and combined spinal infections. MATERIALS AND METHODS: Between June 2001 and November 2006, 30 patients with pyogenic spinal infections were treated in our hospital and outcomes were evaluated through ESR, CRP, and clinical improvement. Groups 1 and 2 represented patients with single lesions and patients with combined lesions, respectively. RESULTS: Group 1 included 7 men and 8 women, and the preoperative mean ESR and CRP were 62.7 mm/hr and 5.7 mg/dl. The most common clinical presentation was back pain. Nine patients in group 1 underwent operation, and two underwent instrumentation. Group 2 included 4 men and 11 women, and the preoperative mean ESR and CRP were 78.5 mm/hr and 16.7 mg/dl. The most common clinical presentations were back pain and fever. Thirteen patients in group 2 underwent operation, and six underwent instrumentation. There were more underlying diseases in group 2. CONCLUSION: There were more underlying diseases and higher preoperative inflammatory-reactive laboratory findings in patients with combined spinal infections. Careful attention must be directed to treatment in order to secure favorable clinical outcomes in patients with combined infections.
Subject(s)
Female , Humans , Male , Back Pain , Fever , Prognosis , Treatment OutcomeABSTRACT
By examining the etiologic serology of 241 cases of hepatitis and the histochemistry of 104 liver biopsies of hepatitis, We have found that the infected persons or infectors who have combined infection with 2-4 viruses are 83 cases (34.4%), with ten types of etiological com- binations. The middle-aged and aged patients possess 38 cases (62.3%) among the patients of superimposed infectors (SI) . The pathological findings of the liver of 48.5% are more se- rious than clinical diagnosis. Compared with simple hepatits A (HA), hapatitis B (HB) and combined infection (CI), SI requires longer duration for treatment and get worse cura- tive effects. It is definitely necessary to treat and isolate the hepatitis patients who have differ- ent etiologies in order to prevent the cross infections.