ABSTRACT
Objective@#To investigate the effects of comfrey cream combined with narrow-band UVB (NB-UVB) on skin barrier function and immune function in the patients with psoriasis vulgaris.@*Methods@#A total of 100 patients with psoriasis vulgaris admitted from March 2016 to June 2017 were enrolled in the study. They were randomly divided into observation group (Purple Cream + NB-UVB) and control group (NB- UVB), 50 cases in each group. Psoriasis lesion area and severity index (PASI) and degree of pruritus were evaluated before treatment, after 2 weeks and 4 weeks of treatment. The skin barrier function and immune related indicators were compared between the two groups before and after the treatment.@*Results@#After treatment, the PASI score and pruritus score of the observation group and the control group showed a decreasing trend, and the observation group decreased more significantly. The interaction between the two groups at different time points, and between groups and at different time points were statistically significant (t values were 3.462, 2.833, P<0.05). After treatment, the water content of the stratum corneum (54.34% ± 5.04% vs. 49.03% ± 5.26%, t=5.154) and the sebum content (143.03 ± 11.60 μg/cm2 vs. 130.79 ± 14.54 μg/cm2, t=4.653) in the observation group were higher than those in the control group, and the transepidermal water loss (TEWL) [15.87 ± 4.22 g/(h•m2) vs. 19.87 ± 3.06 g/(h•m2), t=5.426] in the observation group was lower than that in the control group (P<0.05). The CD4+ (42.06% ± 4.68% vs. 33.01% ± 3.07%, t=11.433), CD4+/CD8+ (20.89 ± 3.44 vs. 26.03 ± 3.44, t=8.209) in observation group and control group were increased after treament, while CD8+(1.89% ± 0.29% vs. 1.43% ± 0.27%, t=7.471) was decreased, the observation group was superior to the control group (P<0.05).@*Conclusions@#Treatment of vulgaris vulgaris with comfrey cream combined with NB-UVB can improve symptoms and improve skin barrier function and immune function.
ABSTRACT
Objective To investigate the effects of comfrey cream combined with narrow-band UVB (NB-UVB) on skin barrier function and immune function in the patients with psoriasis vulgaris. Methods A total of 100 patients with psoriasis vulgaris admitted from March 2016 to June 2017 were enrolled in the study. They were randomly divided into observation group (Purple Cream + NB-UVB) and control group (NB- UVB), 50 cases in each group. Psoriasis lesion area and severity index (PASI) and degree of pruritus were evaluated before treatment, after 2 weeks and 4 weeks of treatment. The skin barrier function and immune related indicators were compared between the two groups before and after the treatment. Results After treatment, the PASI score and pruritus score of the observation group and the control group showed a decreasing trend, and the observation group decreased more significantly. The interaction between the two groups at different time points, and between groups and at different time points were statistically significant (t values were 3.462, 2.833, P<0.05). After treatment, the water content of the stratum corneum (54.34% ±5.04% vs. 49.03% ±5.26%, t=5.154) and the sebum content (143.03 ±11.60 μg/cm2 vs. 130.79 ±14.54 μg/cm2, t=4.653) in the observation group were higher than those in the control group, and the transepidermal water loss (TEWL) [15.87 ± 4.22 g/(h?m2) vs. 19.87 ± 3.06 g/(h?m2), t=5.426] in the observation group was lower than that in the control group (P<0.05). The CD4+(42.06% ±4.68% vs. 33.01% ±3.07%, t=11.433), CD4+/CD8+(20.89 ±3.44 vs. 26.03 ± 3.44, t=8.209) in observation group and control group were increased after treament, while CD8+(1.89% ± 0.29% vs. 1.43% ± 0.27%, t=7.471) was decreased, the observation group was superior to the control group (P<0.05). Conclusions Treatment of vulgaris vulgaris with comfrey cream combined with NB-UVB can improve symptoms and improve skin barrier function and immune function.
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Introducción: Symphytum officinale L. es una hierba perenne de la familia Boraginaceae, de uso medicinal durante muchos años para tratar dolores de articulaciones, músculos, cicatrización de heridas, dolor menstrual, problemas bronquiales, entre otros. Por otro lado, la presencia de polifenoles, triterpenoides y taninos en S. officinale L., permite suponer que la especie bajo estudio puede ser una fuente promisoria de extractos con una alta capacidad antioxidante. Objetivo: evaluar el posible potencial antioxidante de los extractos y del aceite esencial de S. officinale. Métodos: hojas secas y pulverizadas de S. officinale se sometieron a extracciones sucesivas con hexano y etanol hasta agotamiento y el aceite esencial se obtuvo por hidrodestilación. El potencial antioxidante se determinó de acuerdo con su capacidad de atrapamiento del radical estable 2,2-difenil-1-picrilhidrazilo (DPPH, 2-2-diphenyl-1-picrylhydrazyl). Resultados: las muestras evaluadas presentaron valores de EC50 entre 0,06 y 0,44 g muestra/µmol DPPH, similares a extractos naturales como los aceites esenciales de orégano y romero, y de sustancias de referencia como el ácido ascórbico. Conclusiones: las hojas de la planta S. officinale mostraron un efecto antioxidante significativo, lo cual refuerza sus propiedades medicinales en la recuperación de tejidos y dolencias musculares, entre otras afecciones.
Introduction: Symphytum officinale L., is a perennial plant from Boraginaceae family that has been used in medicine for treatment painful joints and muscles, menstruation pain and bronchial problems in addition to stimulating healing of wounds, among other effects. On the other hand, the presence of polyphenols, triterpenoids and tannins in this specie allows us to think that it could be a promising source of natural compounds with high antioxidant activity. Objective: to evaluate the antioxidant potential of the extracts and the essential oil from S. officinale. Methods: dry and powered S. officinale leaves underwent successive extractions with ethanol and hexane and the essential oil was obtained by hydrodistillation. The antioxidant potential was determined on the trapping capacity of stable radical 2-2-diphenyl-1-picrylhydrazyl (DPPH assay). Results: the samples showed EC50 values from 0.06 to 0.44 g sample/µmol DPPH, comparable to natural extracts like the essential oils from oregano and rosemary and to standard substances like ascorbic acid. Conclusions: S. officinale leaves showed an important antioxidant effect, and this result support the medicinal properties of the plant in tissue recovery and therapy for muscular pains and others pathologies.
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Introdução: o estudo da consolidação óssea e dos diversos fatores capazes de estimular o processo de reparo ósseo envolve muitas pesquisas na literatura. Objetivo: testar o efeito do Symphytum officinale na consolidação de fraturas de rádio e ulna em ratos. Método: os autores avaliaram 34 ratos da linhagem Wistar, nos quais foi realizada fratura manual dos ossos do antebraço direito sob anestesia. Os ratos foram divididos aleatoriamente em dois grupos. O grupo experimento recebeu duas gotas da substância Symphytum officinale e o grupo controle recebeu duas gotas de soro fisiológico 0,9%, administradas em ambos na frequência de três vezes ao dia pelo método da gavagem. Após o sacrifício, aos 14 e 28 dias de tratamento, foi realizada dissecção dos rádios e das ulnas. Os ossos foram radiografados e submetidos à leitura da densitometria óptica radiográfica. Resultados: foram observadas diferenças na formação do calo ósseo ulnar em relação ao radial, independentemente do grupo estudado na comparação entre o grupo controle e experimento. Conclusões: a formação do calo ósseo ulnar apresentou maior densidade óssea em relação ao calo radial, independentemente do grupo estudado, e a substância Symphytum officinale, em doses homeopáticas, não se mostrou estimulante da consolidação de fraturas em antebraços de ratos da raça Wistar.
Introduction: there are several studies in medical literature covering the subject of bones consolidation, as well as the several stimulating factors related to it. Objective: to test the effect of Symphytum officinale in bone consolidation of radio and ulna fractures in rats. Method: the authors describe a survey conducted over a sample of 34 rats of Wistar lineage, randomly divided in two different groups, on which a manual procedure to cause the fractures in the bones of the right forearm was conducted with anesthesia. The rats of the experimental group were given two drops of a substance known as Symphytum officinale and the rats of the control group were given two drops of physiologic saline, 0.9%. For those two groups, the drugs were given three times per day by gavage. After the sacrifice of the rats, a series of dissections of the radio and the ulna bones was conducted. All bones were submitted to X-rays and to optical densitometry radiographic devices. Results: a difference in the bone callus formation of ulna was observed when compared to the bone callus formation of radio, regardless of the groups. Conclusions: the bone callus formation of the ulna presented more bone density in relation to radio callus, independently to the studied group and Symphytum officinale, in homeopathic doses, did not stimulate the bone fractures consolidation in forearms of Wistar rats lineage.