ABSTRACT
The material base of TCM of preventing and curing diseases is an organic whole composed of many ingredients,and which has the characteristics of multi component,multi link and multi target.After many years of exploration and accumulation,the component structure theory of TCM based on the whole concept has been improved and developed.This paper systematically discussed cognition of material base of TCM and scientific connotation of innovative structural components of TCM focused on component structure theory,so as to provide strategies and methods for the research and development of modern innovative Chinese medicine preparations.
ABSTRACT
Bioequivalence has an important role in the new drug research, development of non-patent medicine, and post-marketing evaluation of drugs and is an essential step in the standardization and modernization of Chinese materia medica (CMM). With the acceleration of modernization of CMM, CMM preparation products made by different manufacturers differ in quality, resulting in different effects. Therefore, it is very important to strengthen the application of bioequivalent study in CMM preparation products to ensure the effectiveness and safety. In this paper, the research methods of the biological equivalence were introduced systematically, and the significance of the "component structure theory" to the study on biological equivalent of the CMM preparations has been elaborated, in order to improve the evaluation system of the biological equivalent for CMM preparations.